{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418519801469696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.0404875101"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.0404875101"}}],"dc:title":[{"@value":"A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells with a secondary structure-templated chemical library, looking for compounds that inhibit a β-catenin-responsive reporter. We identified ICG-001, a small molecule that down-regulates β-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces<jats:italic>in vitro</jats:italic>growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380294645270504192","@type":"Researcher","foaf:name":[{"@value":"Katayoon H. Emami"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504066","@type":"Researcher","foaf:name":[{"@value":"Cu Nguyen"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504071","@type":"Researcher","foaf:name":[{"@value":"Hong Ma"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504069","@type":"Researcher","foaf:name":[{"@value":"Dae Hoon Kim"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504196","@type":"Researcher","foaf:name":[{"@value":"Kwang Won Jeong"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504064","@type":"Researcher","foaf:name":[{"@value":"Masakatsu Eguchi"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504068","@type":"Researcher","foaf:name":[{"@value":"Randall T. Moon"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504070","@type":"Researcher","foaf:name":[{"@value":"Jia-Ling Teo"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504194","@type":"Researcher","foaf:name":[{"@value":"Se Wong Oh"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504067","@type":"Researcher","foaf:name":[{"@value":"Hak Yeop Kim"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504193","@type":"Researcher","foaf:name":[{"@value":"Sung Hwan Moon"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504065","@type":"Researcher","foaf:name":[{"@value":"Jong Ryul Ha"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645270504195","@type":"Researcher","foaf:name":[{"@value":"Michael Kahn"}],"jpcoar:affiliationName":[{"@value":"Institute for Chemical Genomics, 600 Broadway, Seattle, WA 98122; Howard Hughes Medical Institute and Departments of Pharmacology and Pathobiology, University of Washington, Seattle, WA 98195; and Choong Wae Pharma Corporation, Hwasung City 146-141, Kyunggido 445-970, Korea"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2004-08-16","prism:volume":"101","prism:number":"34","prism:startingPage":"12682","prism:endingPage":"12687"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.0404875101"}],"createdAt":"2004-08-17","modifiedAt":"2024-01-14","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810812299392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Targeting the canonical Wnt/β-catenin pathway in hematological malignancies"},{"@value":"Targeting the canonical Wnt/β‐catenin pathway in hematological malignancies"},{"@value":"Targeting the canonical 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