{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418520057526016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1460-9568.2007.05818.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1460-9568.2007.05818.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1460-9568.2007.05818.x"}}],"dc:title":[{"@value":"BDNF/ TrkB interaction regulates migration of SVZ precursor cells via PI3‐K and MAP‐K signalling pathways"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Neuroblasts born in the subventricular zone (SVZ) migrate along the rostral migratory stream, reaching the olfactory bulb (OB) where they differentiate into local interneurons. Several extracellular factors have been suggested to control specific steps of this process. The brain‐derived neurotrophic factor (BDNF) has been demonstrated to promote morphological differentiation and survival of OB interneurons. Here we show that BDNF and its receptor TrkB are expressed <jats:italic>in vivo</jats:italic> throughout the migratory pathway, implying that BDNF might also mediate migratory signals. By using <jats:italic>in vitro</jats:italic> models we demonstrate that BDNF promotes migration of SVZ neuroblasts, acting both as inducer and attractant through TrkB activation. We show that BDNF induces cAMP response element‐binding protein (CREB) activation in migrating neuroblasts via phosphatidylinositol 3‐kinase (PI3‐K) and mitogen‐activated protein kinase (MAP‐K) signalling. Pharmacological blockade of these pathways on SVZ explants significantly reduces CREB activation and impairs neuronal migration. This study identifies a function of BDNF in the SVZ system, which involves multiple protein kinase pathways leading to neuroblast migration.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418520057526018","@type":"Researcher","foaf:name":[{"@value":"S. Chiaramello"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520057526023","@type":"Researcher","foaf:name":[{"@value":"G. Dalmasso"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520057526021","@type":"Researcher","foaf:name":[{"@value":"L. Bezin"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520057526022","@type":"Researcher","foaf:name":[{"@value":"D. Marcel"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520057526020","@type":"Researcher","foaf:name":[{"@value":"F. Jourdan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520057526019","@type":"Researcher","foaf:name":[{"@value":"P. Peretto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520057526016","@type":"Researcher","foaf:name":[{"@value":"A. Fasolo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520057526017","@type":"Researcher","foaf:name":[{"@value":"S. De Marchis"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0953816X"},{"@type":"EISSN","@value":"14609568"}],"prism:publicationName":[{"@value":"European Journal of Neuroscience"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2007-09-25","prism:volume":"26","prism:number":"7","prism:startingPage":"1780","prism:endingPage":"1790"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1460-9568.2007.05818.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1460-9568.2007.05818.x"}],"createdAt":"2007-09-22","modifiedAt":"2023-10-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050869456405652480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Heterogeneous distribution of doublecortin-expressing cells surrounding the rostral migratory stream in the juvenile mouse"},{"@value":"Heterogeneous distribution of doublecortin‐expressing cells surrounding the rostral migratory stream in the juvenile mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694647139712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Girdin Is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302866831963392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histological changes in the olfactory bulb and rostral migratory stream due to interruption of olfactory input"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1460-9568.2007.05818.x"},{"@type":"CROSSREF","@value":"10.1523/jneurosci.1130-11.2011_references_DOI_KygXUKmJIz3lG5CeyG3MLEtbmAL"},{"@type":"CROSSREF","@value":"10.1016/j.anl.2024.01.009_references_DOI_KygXUKmJIz3lG5CeyG3MLEtbmAL"},{"@type":"CROSSREF","@value":"10.1002/cne.24521_references_DOI_KygXUKmJIz3lG5CeyG3MLEtbmAL"}]}