{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418520142099712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1473-2165.2010.00476.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1473-2165.2010.00476.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1473-2165.2010.00476.x"}}],"dc:title":[{"@value":"A double‐blind study of tolerance and efficacy of a new urea‐containing moisturizer in patients with atopic dermatitis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p><jats:bold>Background </jats:bold> Atopic dermatitis patients almost all use moisturizers to prevent and treat their skin disease. However, the safety and efficacy of moisturizers are rarely studied in this patient population.</jats:p><jats:p><jats:bold>Aims </jats:bold> To evaluate the efficacy and tolerability of urea‐containing moisturizers in subjects with atopic dermatitis.</jats:p><jats:p><jats:bold>Methods </jats:bold> One hundred subjects with atopic dermatitis were randomized to apply either a new 5% urea moisturizer or a commercially available 10% urea lotion twice a day for 42 days. Scoring Atopic Dermatitis severity index (SCORAD) was performed at Day 0 and Day 42. Cosmetic acceptability questionnaires, adverse events, and a 5‐point tolerance evaluation were administered or performed at Day 42.</jats:p><jats:p><jats:bold>Results </jats:bold> Both study products were very well tolerated by subjects and only three subjects discontinued their participation in the study due to adverse events. Mean SCORAD significantly decreased between Day 0 and Day 42 by 19.76% and 19.23%, respectively, for subjects treated with the new 5% urea moisturizer or the 10% urea lotion (<jats:italic>P</jats:italic> < 0.001). There was no difference between the two products in SCORAD reduction; however, significantly more subjects preferred using the new 5% urea moisturizer as compared with the 10% urea lotion.</jats:p><jats:p><jats:bold>Conclusions </jats:bold> Both the new 5% urea moisturizer and the 10% urea lotion improved atopic dermatitis and were very well tolerated. However, the cosmetic acceptability questionnaire showed that subjects preferred using the new 5% urea moisturizer over the 10% urea lotion.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418520142099840","@type":"Researcher","foaf:name":[{"@value":"Robert Bissonnette"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520142099712","@type":"Researcher","foaf:name":[{"@value":"Catherine Maari"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520142099713","@type":"Researcher","foaf:name":[{"@value":"Nathalie Provost"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520142099716","@type":"Researcher","foaf:name":[{"@value":"Chantal Bolduc"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520142099717","@type":"Researcher","foaf:name":[{"@value":"Simon Nigen"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520142099714","@type":"Researcher","foaf:name":[{"@value":"André Rougier"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520142099715","@type":"Researcher","foaf:name":[{"@value":"Sophie Seite"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14732130"},{"@type":"EISSN","@value":"14732165"}],"prism:publicationName":[{"@value":"Journal of Cosmetic Dermatology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2010-02-22","prism:volume":"9","prism:number":"1","prism:startingPage":"16","prism:endingPage":"21"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1473-2165.2010.00476.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1473-2165.2010.00476.x"}],"createdAt":"2010-02-22","modifiedAt":"2023-11-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360572092648921088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1473-2165.2010.00476.x"},{"@type":"CROSSREF","@value":"10.3390/ijms21207607_references_DOI_2vUBVJ2cTXzyVaUDfPEAc26oOoX"}]}