{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418520189910784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1191184"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1191184"}}],"dc:title":[{"@value":"Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Form and Function</jats:title>\n                  <jats:p>\n                    The Planar Cell Polarity (PCP) signaling pathway governs cell movements that drive axis elongation and neural tube closure in vertebrate embryos, and certain vertebrate PCP proteins have also been implicated in ciliogenesis. Likewise, the septin cytoskeleton controls diverse cell behaviors, such as cytokinesis and cell migration, but little is known about how septin functions are regulated in vivo.\n                    <jats:bold>\n                      Kim\n                      <jats:italic>et al.</jats:italic>\n                    </jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"1337\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126/science.1191184\">1337</jats:related-article>\n                    , published online 29 July; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"5997\" page=\"1289\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126/science.1195445\">Barral</jats:related-article>\n                    </jats:bold>\n                    ) found that control of septins by the PCP effector protein, Fritz, was a crucial control point for morphogenesis and ciliogenesis. During neural tube closure, Fritz-mediated septin localization maintained cell shape but not cell polarity. In ciliated epithelial cells, Fritz was required for assembly of the septin rings at the base of cilia, which are needed for normal ciliogenesis and signaling.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418520189910658","@type":"Researcher","foaf:name":[{"@value":"Su Kyoung Kim"}],"jpcoar:affiliationName":[{"@value":"Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910656","@type":"Researcher","foaf:name":[{"@value":"Asako Shindo"}],"jpcoar:affiliationName":[{"@value":"Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910657","@type":"Researcher","foaf:name":[{"@value":"Tae Joo Park"}],"jpcoar:affiliationName":[{"@value":"Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910785","@type":"Researcher","foaf:name":[{"@value":"Edwin C. Oh"}],"jpcoar:affiliationName":[{"@value":"Center for Human Disease Modeling, Departments of Cell Biology and Pediatrics, Duke University, Durham, NC 27710, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910788","@type":"Researcher","foaf:name":[{"@value":"Srimoyee Ghosh"}],"jpcoar:affiliationName":[{"@value":"Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910786","@type":"Researcher","foaf:name":[{"@value":"Ryan S. Gray"}],"jpcoar:affiliationName":[{"@value":"Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910789","@type":"Researcher","foaf:name":[{"@value":"Richard A. Lewis"}],"jpcoar:affiliationName":[{"@value":"Departments of Ophthalmology, Medicine, Pediatrics, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910790","@type":"Researcher","foaf:name":[{"@value":"Colin A. Johnson"}],"jpcoar:affiliationName":[{"@value":"Sections of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, LS9 7TF, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910784","@type":"Researcher","foaf:name":[{"@value":"Tania Attie-Bittach"}],"jpcoar:affiliationName":[{"@value":"Département de Génétique, INSERM U781, Hôpital Necker–Enfants Malades, Université Paris Descartes, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910659","@type":"Researcher","foaf:name":[{"@value":"Nicholas Katsanis"}],"jpcoar:affiliationName":[{"@value":"Center for Human Disease Modeling, Departments of Cell Biology and Pediatrics, Duke University, Durham, NC 27710, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520189910787","@type":"Researcher","foaf:name":[{"@value":"John B. Wallingford"}],"jpcoar:affiliationName":[{"@value":"Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA."},{"@value":"Howard Hughes Medical Institute, University of Texas at Austin, Austin, TX 78712, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2010-09-10","prism:volume":"329","prism:number":"5997","prism:startingPage":"1337","prism:endingPage":"1340"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1191184"}],"createdAt":"2010-07-29","modifiedAt":"2024-01-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001338813793280","@type":"Article","resourceType":"学術雑誌論文(journal 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