Absorption of Chlorogenic Acid and Caffeic Acid in Rats after Oral Administration
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- Keiko Azuma
- National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan, and Department of Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho 3, Tokushima 770, Japan
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- Katsunari Ippoushi
- National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan, and Department of Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho 3, Tokushima 770, Japan
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- Masayoshi Nakayama
- National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan, and Department of Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho 3, Tokushima 770, Japan
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- Hidekazu Ito
- National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan, and Department of Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho 3, Tokushima 770, Japan
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- Hisao Higashio
- National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan, and Department of Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho 3, Tokushima 770, Japan
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- Junji Terao
- National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan, and Department of Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho 3, Tokushima 770, Japan
書誌事項
- 公開日
- 2000-10-07
- DOI
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- 10.1021/jf000483q
- 公開者
- American Chemical Society (ACS)
この論文をさがす
説明
Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. Rats were administered 700 micromol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. Ingested caffeic acid was absorbed from the alimentary tract and was present in the rat blood circulation in the form of various metabolites. On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid administration. These results suggest that chlorogenic acid is not well absorbed from the digestive tract, unlike caffeic acid, and subject to almost no structural changes to the easily absorbed forms.
収録刊行物
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- Journal of Agricultural and Food Chemistry
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Journal of Agricultural and Food Chemistry 48 (11), 5496-5500, 2000-10-07
American Chemical Society (ACS)