{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418520596004352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/jf026108a"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/jf026108a"}},{"identifier":{"@type":"PMID","@value":"12696973"}}],"dc:title":[{"@value":"Absorption and Urinary Excretion of Quercetin, Rutin, and αG-Rutin, a Water Soluble Flavonoid, in Rats"}],"description":[{"notation":[{"@value":"Quercetin, rutin, alphaG-rutin (a water soluble flavonoid), and a mixture of rutin and alphaG-rutin were administered to rats by a single gastric intubation, and their absorption and urinary excretion were examined. The plasma and 24 h urinary levels of aglycons (quercetin and tamarixetin/isorhamnetin) were measured by HPLC after deconjugation with beta-glucuronidase/sulfatase treatment. alphaG-rutin was absorbed more rapidly than quercetin or rutin, and the plasma concentrations of quercetin and tamarixetin/isorhamnetin reached the highest peak level 30 min after dosing. Quercetin, rutin, and the mixture of rutin and alphaG-rutin showed the first peak level 8 h, 8 h, and 30 min after dosing, respectively. The area under the concentration-time curve (AUC) for quercetin in rats administered alphaG-rutin was approximately 4.5- and 2-fold higher than those in rats administered quercetin and rutin, respectively, and was almost the same as that in rats administered a mixture of rutin and alphaG-rutin. The highest 24 h urinary excretion was observed in alphaG-rutin-administered rats. These results suggest that alphaG-rutin is absorbed more efficiently than either quercetin or rutin and that a high plasma concentration can be maintained by supplying rutin and alphaG-rutin in combination."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418520596004354","@type":"Researcher","foaf:name":[{"@value":"Kayoko Shimoi"}],"jpcoar:affiliationName":[{"@value":"Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52-1, Shizuoka 422-8526, Japan, and Toyo Sugar Refining Company, Ltd., Koami-chou 18-20, Nihonbashi, Tyuou-ku, Tokyo 103-0016, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520596004355","@type":"Researcher","foaf:name":[{"@value":"Kazuma Yoshizumi"}],"jpcoar:affiliationName":[{"@value":"Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52-1, Shizuoka 422-8526, Japan, and Toyo Sugar Refining Company, Ltd., Koami-chou 18-20, Nihonbashi, Tyuou-ku, Tokyo 103-0016, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520596004352","@type":"Researcher","foaf:name":[{"@value":"Taketoshi Kido"}],"jpcoar:affiliationName":[{"@value":"Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52-1, Shizuoka 422-8526, Japan, and Toyo Sugar Refining Company, Ltd., Koami-chou 18-20, Nihonbashi, Tyuou-ku, Tokyo 103-0016, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520596004356","@type":"Researcher","foaf:name":[{"@value":"Yumiko Usui"}],"jpcoar:affiliationName":[{"@value":"Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52-1, Shizuoka 422-8526, Japan, and Toyo Sugar Refining Company, Ltd., Koami-chou 18-20, Nihonbashi, Tyuou-ku, Tokyo 103-0016, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418520596004353","@type":"Researcher","foaf:name":[{"@value":"Takashi Yumoto"}],"jpcoar:affiliationName":[{"@value":"Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52-1, Shizuoka 422-8526, Japan, and Toyo Sugar Refining Company, Ltd., Koami-chou 18-20, Nihonbashi, Tyuou-ku, Tokyo 103-0016, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00218561"},{"@type":"EISSN","@value":"15205118"}],"prism:publicationName":[{"@value":"Journal of Agricultural and Food Chemistry"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2003-03-28","prism:volume":"51","prism:number":"9","prism:startingPage":"2785","prism:endingPage":"2789"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/jf026108a"}],"createdAt":"2003-04-16","modifiedAt":"2021-10-04","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Rutin","dc:title":"Rutin"},{"@id":"https://cir.nii.ac.jp/all?q=Administration,%20Oral","dc:title":"Administration, Oral"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Absorption","dc:title":"Intestinal Absorption"},{"@id":"https://cir.nii.ac.jp/all?q=Solubility","dc:title":"Solubility"},{"@id":"https://cir.nii.ac.jp/all?q=Area%20Under%20Curve","dc:title":"Area Under Curve"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Quercetin","dc:title":"Quercetin"},{"@id":"https://cir.nii.ac.jp/all?q=Nutritive%20Value","dc:title":"Nutritive Value"},{"@id":"https://cir.nii.ac.jp/all?q=Trisaccharides","dc:title":"Trisaccharides"},{"@id":"https://cir.nii.ac.jp/all?q=Chromatography,%20High%20Pressure%20Liquid","dc:title":"Chromatography, High Pressure Liquid"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567182256151296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189645121152","@type":"Article","resourceType":"学術雑誌論文(journal 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pulse radiolysis: as a basis for radiation protection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694369434758016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design and evaluation of a novel flavonoid-based radioprotective agent utilizing monoglucosyl rutin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206479569024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bioavailability of Glucosyl Hesperidin in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679605173120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enzymatically Modified Isoquercitrin, .ALPHA.-Oligoglucosyl Quercetin 3-O-Glucoside, Is Absorbed More Easily than Other Quercetin Glycosides or Aglycone after Oral Administration in 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