{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418521069227776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1365-2567.2005.02316.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2567.2005.02316.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2567.2005.02316.x"}}],"dc:title":[{"@value":"Dealing with the family: CD147 interactions with cyclophilins"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>CD147 is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as <jats:italic>e</jats:italic>xtracellular <jats:italic>m</jats:italic>atrix <jats:italic>m</jats:italic>etallo<jats:italic>pr</jats:italic>oteinase <jats:italic>in</jats:italic>ducer (hence the other name for this protein, EMMPRIN), but has also been shown to regulate lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. These functions reflect multiple interacting partners of CD147. Recently, interaction of CD147 with proteins of the cyclophilin family has been demonstrated and activity of CD147 as a signalling receptor to extarcellular cyclophilins A and B has been shown. Given that extracellular cyclophilins are potent chemotactic agents for various immune cells, further studies of the role of cyclophilin–CD147 interaction in inflammation followed. They demonstrated that agents targeting CD147 or cyclophilin had a significant anti‐inflammatory effect in animal models of acute or chronic lung diseases and rheumatoid arthritis. Here, we review the current knowledge about interactions between CD147 and cyclophilins.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418521069227776","@type":"Researcher","foaf:name":[{"@value":"Vyacheslav Yurchenko"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521069227778","@type":"Researcher","foaf:name":[{"@value":"Stephanie Constant"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521069227777","@type":"Researcher","foaf:name":[{"@value":"Michael Bukrinsky"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00192805"},{"@type":"EISSN","@value":"13652567"}],"prism:publicationName":[{"@value":"Immunology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2006-02-13","prism:volume":"117","prism:number":"3","prism:startingPage":"301","prism:endingPage":"309"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2567.2005.02316.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2567.2005.02316.x"}],"createdAt":"2005-12-22","modifiedAt":"2023-10-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001338813734400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231952710400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Basigin/CD147 Promotes Renal Fibrosis after Unilateral Ureteral Obstruction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168838044672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intravenous injection of cyclophilin A realizes the transient and reversible opening of barrier of neural vasculature through basigin in endothelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567179896158464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD147/Basigin Limits Lupus Nephritis and Th17 Cell Differentiation in Mice by Inhibiting the Interleukin‐6/STAT‐3 Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656157479296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cyclosporin A induces the unfolded protein response in keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975841447607424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/2051151842050872960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD147/basigin reflects renal dysfunction in patients with acute kidney injury"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1365-2567.2005.02316.x"},{"@type":"CROSSREF","@value":"10.1007/s10157-017-1518-2_references_DOI_G0AP0CK5aD7c0emESjNpvBbeaHh"},{"@type":"CROSSREF","@value":"10.1016/j.ajpath.2019.04.003_references_DOI_G0AP0CK5aD7c0emESjNpvBbeaHh"},{"@type":"CROSSREF","@value":"10.1038/s41598-021-98163-w_references_DOI_G0AP0CK5aD7c0emESjNpvBbeaHh"},{"@type":"CROSSREF","@value":"10.1002/art.39155_references_DOI_G0AP0CK5aD7c0emESjNpvBbeaHh"},{"@type":"CROSSREF","@value":"10.1007/s00403-010-1099-3_references_DOI_G0AP0CK5aD7c0emESjNpvBbeaHh"},{"@type":"CROSSREF","@value":"10.1007/s10157-013-0916-3_references_DOI_G0AP0CK5aD7c0emESjNpvBbeaHh"},{"@type":"CROSSREF","@value":"10.1016/j.ajpath.2010.10.009_references_DOI_G0AP0CK5aD7c0emESjNpvBbeaHh"}]}