{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418521076545152.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.hyp.0000113294.06704.64"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000113294.06704.64"}},{"identifier":{"@type":"NAID","@value":"30022677802"}}],"dc:title":[{"@value":"Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Plasma levels of aldosterone are not always predictable from the activity of renin and the concentration of potassium. Among the unexplained are elevated levels of aldosterone in some obese humans. Obesity is characterized by increased plasma fatty acids and oxidative stress. We postulated that oxidized fatty acids stimulate aldosteronogenesis. The most readily oxidized fatty acids are the polyunsaturated, and the most abundant of those is linoleic acid. We tested oxidized derivatives of linoleic acid for effects on rat adrenal cells. One derivative, 12,13-epoxy-9-keto-10(\n            <jats:italic>trans</jats:italic>\n            )-octadecenoic acid (EKODE), was particularly potent. EKODE stimulated aldosteronogenesis at concentrations from 0.5 to 5 μmol/L, and inhibited aldosteronogenesis at higher doses. EKODE’s stimulatory effect was most prominent when angiotensin and potassium effects were submaximal. The lipid’s mechanism of action was on the early pathway leading to pregnenolone; its action was inhibited by atrial natriuretic peptide. Plasma EKODE was measured by liquid chromatography/mass spectrometry. All human plasmas tested contained EKODE in concentrations ranging from 10\n            <jats:sup>−9</jats:sup>\n            to 5×10\n            <jats:sup>−7</jats:sup>\n            mol/L. In samples from 24 adults, levels of EKODE correlated directly with aldosterone (\n            <jats:italic>r</jats:italic>\n            =0.53,\n            <jats:italic>P</jats:italic>\n            =0.007). In the 12 blacks in that cohort, EKODE also correlated with body mass index and systolic pressure. Those other correlations were not seen in white subjects. The results suggest that oxidized derivatives of polyunsaturated fatty acids other than arachidonic are biologically active. Compounds like EKODE, derived from linoleic acid, may affect adrenal steroid production in humans and mediate some of the deleterious effects of obesity and oxidative stress, especially in blacks.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418521076545153","@type":"Researcher","foaf:name":[{"@value":"Theodore L. Goodfriend"}],"jpcoar:affiliationName":[{"@value":"From the William S. Middleton Memorial Veterans Hospital and Departments of Medicine and Pharmacology of the University of Wisconsin (T.L.G., D.L.B.); Madison; Department of Medicine (B.M.E.), Medical University of South Carolina, Charleston; and Department of Pharmacology (W.B.C., K.N.), Medical College of Wisconsin, Milwaukee."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521076545155","@type":"Researcher","foaf:name":[{"@value":"Dennis L. Ball"}],"jpcoar:affiliationName":[{"@value":"From the William S. Middleton Memorial Veterans Hospital and Departments of Medicine and Pharmacology of the University of Wisconsin (T.L.G., D.L.B.); Madison; Department of Medicine (B.M.E.), Medical University of South Carolina, Charleston; and Department of Pharmacology (W.B.C., K.N.), Medical College of Wisconsin, Milwaukee."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521076545152","@type":"Researcher","foaf:name":[{"@value":"Brent M. Egan"}],"jpcoar:affiliationName":[{"@value":"From the William S. Middleton Memorial Veterans Hospital and Departments of Medicine and Pharmacology of the University of Wisconsin (T.L.G., D.L.B.); Madison; Department of Medicine (B.M.E.), Medical University of South Carolina, Charleston; and Department of Pharmacology (W.B.C., K.N.), Medical College of Wisconsin, Milwaukee."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521076545156","@type":"Researcher","foaf:name":[{"@value":"William B. Campbell"}],"jpcoar:affiliationName":[{"@value":"From the William S. Middleton Memorial Veterans Hospital and Departments of Medicine and Pharmacology of the University of Wisconsin (T.L.G., D.L.B.); Madison; Department of Medicine (B.M.E.), Medical University of South Carolina, Charleston; and Department of Pharmacology (W.B.C., K.N.), Medical College of Wisconsin, Milwaukee."}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521076545154","@type":"Researcher","foaf:name":[{"@value":"Kasem Nithipatikom"}],"jpcoar:affiliationName":[{"@value":"From the William S. Middleton Memorial Veterans Hospital and Departments of Medicine and Pharmacology of the University of Wisconsin (T.L.G., D.L.B.); Madison; Department of Medicine (B.M.E.), Medical University of South Carolina, Charleston; and Department of Pharmacology (W.B.C., K.N.), Medical College of Wisconsin, Milwaukee."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/0194911X"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/0194911X"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2004-02","prism:volume":"43","prism:number":"2","prism:startingPage":"358","prism:endingPage":"363"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000113294.06704.64"}],"createdAt":"2004-01-13","modifiedAt":"2024-05-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233405541760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mineralocorticoid receptor activation in obesity hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142766395520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Mineralocorticoid Receptor in Salt-Sensitive Hypertension and Renal Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708441525888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710424932992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aberrant Rac1–mineralocorticoid receptor pathways in salt‐sensitive hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714182115712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathophysiology of salt sensitivity hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286993324446080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation of the pathophysiological mechanisms of salt-sensitive hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617774020480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of Rho in Salt-Sensitive Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865736198912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of Reversal of Renin Suppression With Long-Term Renal Outcome in Medically Treated Primary Aldosteronism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183359546752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"[Scientific Statement]"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641714903040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mineralocorticoid Receptor-Associated Hypertension and Its Organ Damage: Clinical Relevance for Resistant Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642438488576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of Aldosterone in Obesity-Related Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643661324800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660422823296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased urinary aldosterone excretion is associated with subcutaneous not visceral, adipose tissue area in obese individuals: a possible manifestation of dysfunctional subcutaneous adipose tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567726550400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Kidney and epigenetic mechanisms of salt-sensitive hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694371324603648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sex Difference in the Association Between Subtype Distribution and Age at Diagnosis in Patients With Primary Aldosteronism"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206444475648","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Internal Medicine Corresponding to Both the Mass and Individuals - Pathophisiology and Treatment of Hypertension"},{"@language":"ja","@value":"マスと個に対応する内科学～高血圧の病態と治療～"},{"@value":"会頭講演 マスと個に対応する内科学--高血圧の病態と治療"},{"@language":"ja-Kana","@value":"カイトウ コウエン マス ト コ ニ タイオウスル ナイカガク コウケツアツ ノ ビョウタイ ト チリョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206445655168","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical condition of metabolic syndrome. 3 Metabolic syndrome and aldosterone"},{"@language":"ja","@value":"メタボリックシンドロームの臨床　　メタボリックシンドロームとアルドステロン"},{"@value":"追加発言 メタボリックシンドロームとアルドステロン"},{"@language":"ja-Kana","@value":"ツイカ ハツゲン メタボリックシンドローム ト アルドステロン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681421206400","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"3) Aldosterone and Adult Disease"},{"@language":"ja","@value":"3）アルドステロンと生活習慣病"},{"@value":"アルドステロンと生活習慣病"},{"@language":"ja-Kana","@value":"アルドステロン ト セイカツ シュウカンビョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651253319296","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026125697792","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"From aldosteronism to oxidative stress : the role of excessive intracellular calcium accumulation"}]},{"@id":"https://cir.nii.ac.jp/crid/2051996266980601600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/01.hyp.0000113294.06704.64"},{"@type":"CIA","@value":"30022677802"},{"@type":"CROSSREF","@value":"10.1007/s10157-010-0298-8_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1038/hr.2009.86_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.2169/naika.95.1726_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1681/asn.2020071041_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1161/hypertensionaha.119.13006_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1038/s41440-018-0158-6_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1111/1440-1681.12177_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.3109/07853890.2012.671538_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1038/s41440-019-0332-5_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.3390/ijms22062958_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1161/hypertensionaha.123.21096_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1038/hr.2013.102_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.2169/naika.97.2160_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.2169/naika.97.37a_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1038/ajh.2011.245_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1093/ajh/hpw003_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1161/hypertensionaha.109.149062_references_DOI_R6B1tIUBOsASabZiLDgl0AZfNmS"},{"@type":"CROSSREF","@value":"10.1111/cen.12083_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"},{"@type":"CROSSREF","@value":"10.1038/s41581-021-00399-2_references_DOI_Z3tOZk3kbNAifZkYfFowjIPb3p0"}]}