{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418521208587776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/jaha.116.003769"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/JAHA.116.003769"}}],"dc:title":[{"@value":"Association of Age at Menopause With Incident Heart Failure: A Prospective Cohort Study and Meta‐Analysis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background</jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Early age (<45 years) at menopause has been postulated to be associated with increased cardiovascular disease risk; however, evidence of its relation with heart failure (\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      ) incidence is limited. We examined whether age at menopause is associated inversely with\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      incidence in the Atherosclerosis Risk In Communities (\n                      <jats:styled-content style=\"fixed-case\">ARIC</jats:styled-content>\n                      ) study and summarized all existing data in a meta‐analysis.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results</jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In\n                      <jats:styled-content style=\"fixed-case\">ARIC</jats:styled-content>\n                      , data were obtained from 5629 postmenopausal women (mean age 56 years, 26% with bilateral oophorectomy) without\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      . During a median follow‐up of 21.4 years, 965 incident\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      events occurred. In a Cox regression model adjusted for reproductive health and\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      risk factors, the hazard ratios for incident\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      across categories of age at menopause (<45, 45–49, 50–54, and ≥55 years) were 1.32, 1.17, 1.00 (referent), and 1.12, respectively. Compared with women with later onset of menopause (aged ≥45 years), those with early menopause had elevated\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      risk (hazard ratio 1.20, 95%\n                      <jats:styled-content style=\"fixed-case\">CI</jats:styled-content>\n                      1.01–1.43). For the meta‐analysis, we searched Medline and Embase for articles published through December 2015 that prospectively evaluated age at menopause and\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      risk. Summarized estimates from the 3 included studies (3568 events) showed higher\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      risk among women with early menopause compared with those with later menopause (hazard ratio 1.33, 95%\n                      <jats:styled-content style=\"fixed-case\">CI</jats:styled-content>\n                      1.15–1.53).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p xml:lang=\"en\">\n                      These results provided evidence that early age at menopause is associated with a modestly greater risk of\n                      <jats:styled-content style=\"fixed-case\">HF</jats:styled-content>\n                      . Identification of women with early menopause offers a window of opportunity to implement interventions that will improve overall cardiovascular health during the postmenopausal years.\n                    </jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418521208587776","@type":"Researcher","foaf:name":[{"@value":"Duke Appiah"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521208587650","@type":"Researcher","foaf:name":[{"@value":"Pamela J. Schreiner"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521208587649","@type":"Researcher","foaf:name":[{"@value":"Ellen W. Demerath"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521208587651","@type":"Researcher","foaf:name":[{"@value":"Laura R. Loehr"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology, University of North Carolina, Chapel Hill, NC"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521208587648","@type":"Researcher","foaf:name":[{"@value":"Patricia P. Chang"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology, Department of Medicine, University of North Carolina, Chapel Hill, NC"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521208587777","@type":"Researcher","foaf:name":[{"@value":"Aaron R. Folsom"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20479980"}],"prism:publicationName":[{"@value":"Journal of the American Heart Association"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2016-08-08","prism:volume":"5","prism:number":"8"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/JAHA.116.003769"}],"createdAt":"2016-07-28","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001205226163584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Circadian Blood Pressure Variations in Postmenopausal Females with Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1390578437525547392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/jaha.116.003769"},{"@type":"CROSSREF","@value":"10.1536/ihj.17-206_references_DOI_UANKrm2G7qhHyZ3WviZES6IBY6j"},{"@type":"CROSSREF","@value":"10.5551/jat.63592_references_DOI_UANKrm2G7qhHyZ3WviZES6IBY6j"}]}