{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418521308523264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/ajpregu.00074.2006"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/ajpregu.00074.2006"}}],"dc:title":[{"@value":"Impaired defense of core temperature in aged humans during mild cold stress"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Aged humans often exhibit an impaired defense of core temperature during cold stress. However, research documenting this response has typically used small subject samples and strong cold stimuli. The purpose of this study was to determine the responses of young and older subjects, matched for anthropometric characteristics, during mild cold stress. Thirty-six young (YS; 23 ± 1 years, range 18–30) and 46 older (OS; 71 ± 1 years, range 65–89) subjects underwent a slow transient cold air exposure from a thermoneutral baseline, during which esophageal (T<jats:sub>es</jats:sub>) and mean skin temperatures (T<jats:sub>sk</jats:sub>), O<jats:sub>2</jats:sub> consumption, and skin blood flow (SkBF; laser-Doppler flowmetry) were measured. Cold exposure was terminated at the onset of visible sustained shivering. Net metabolic heat production (M<jats:sub>net</jats:sub>), heat debt, predicted change in midregion temperature (ΔT<jats:sub>mid</jats:sub>), and tissue insulation (I<jats:sub>t</jats:sub>) were calculated. Cutaneous vascular conductance (CVC) was calculated as laser-Doppler flux/mean arterial pressure and expressed as percent change from baseline (ΔCVC<jats:sub>%base</jats:sub>). There were no baseline group differences for T<jats:sub>es</jats:sub>, but OS M<jats:sub>net</jats:sub> was lower (OS: 38.0 ± 1.1; YS: 41.9 ± 1.1 W · m<jats:sup>−2</jats:sup>, P < 0.05). T<jats:sub>es</jats:sub> was well maintained in YS but fell progressively in OS ( P < 0.01 for all timepoints after 35 min). The skin vasoconstrictor response to mild cold stress was attenuated in OS (42 ± 3 vs. 53 ± 4 ΔCVC<jats:sub>%base</jats:sub>, P < 0.01). There were no group differences for T<jats:sub>sk</jats:sub> or I<jats:sub>t</jats:sub>, while M<jats:sub>net</jats:sub> remained lower in OS ( P < 0.05). The ΔT<jats:sub>mid</jats:sub> did not account for the drop in T<jats:sub>es</jats:sub> in OS. Healthy aged humans failed to maintain T<jats:sub>es</jats:sub>; however, the mechanisms underlying this response are not clear. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418521308523265","@type":"Researcher","foaf:name":[{"@value":"David W. DeGroot"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418521308523264","@type":"Researcher","foaf:name":[{"@value":"W. Larry Kenney"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03636119"},{"@type":"EISSN","@value":"15221490"}],"prism:publicationName":[{"@value":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"2007-01","prism:volume":"292","prism:number":"1","prism:startingPage":"R103","prism:endingPage":"R108"},"reviewed":"false","url":[{"@id":"https://www.physiology.org/doi/pdf/10.1152/ajpregu.00074.2006"}],"createdAt":"2006-05-26","modifiedAt":"2019-09-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285707408468864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sex differences in age-related changes on peripheral warm and cold innocuous thermal sensitivity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757192149888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer’s Disease-Related Pathologies"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680183672064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Vertical Air Temperature Gradients on Physiological and Psychological Responses in the Elderly"}]},{"@id":"https://cir.nii.ac.jp/crid/1390861725896546560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association between temperature and mortality: a multi-city time series study in Sichuan Basin, southwest China"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1152/ajpregu.00074.2006"},{"@type":"CROSSREF","@value":"10.1618/jhes.14.9_references_DOI_EpI02gTlmvt8yfKIHT2K7d3Ga8l"},{"@type":"CROSSREF","@value":"10.1016/j.physbeh.2016.05.045_references_DOI_EpI02gTlmvt8yfKIHT2K7d3Ga8l"},{"@type":"CROSSREF","@value":"10.3390/ijms24032741_references_DOI_EpI02gTlmvt8yfKIHT2K7d3Ga8l"},{"@type":"CROSSREF","@value":"10.1265/ehpm.23-00118_references_DOI_EpI02gTlmvt8yfKIHT2K7d3Ga8l"}]}