{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361694364565007232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/hon.2730"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhon.2730"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hon.2730"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hon.2730"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1002%2Fhon.2730"}},{"identifier":{"@type":"PMID","@value":"32196124"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Good prognosis for follicular lymphoma with estrogen receptor α‐positive follicular dendritic cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Follicular lymphoma (FL) has a meshwork of follicular dendritic cells (FDCs). We previously demonstrated the presence of estrogen receptor alpha (ERα)\n                    <jats:sup>+</jats:sup>\n                    CD23\n                    <jats:sup>+</jats:sup>\n                    FDCs in grades 1‐2 FL. The significance of FDCs as a prognostic factor in FL remains unknown. The current study aimed to compare clinicopathological features, including prognosis, between FL with and without ERα\n                    <jats:sup>+</jats:sup>\n                    FDCs. This study evaluated the clinicopathological significance of ERα expression in 70 FL patients by immunostaining. The presence of\n                    <jats:italic>ERα</jats:italic>\n                    mRNA on FDCs from 5 FL patients was confirmed by CD21/\n                    <jats:italic>ERα</jats:italic>\n                    double staining (immunohistochemistry and in situ hybridization). We defined patients with frequent ERα expression as the ERα\n                    <jats:sup>high</jats:sup>\n                    group and those with infrequent ERα expression as the ERα\n                    <jats:sup>low</jats:sup>\n                    group. Thirty‐two patients were assigned to the ERα\n                    <jats:sup>high</jats:sup>\n                    group (45.7%), and 38 patients were assigned to the ERα\n                    <jats:sup>low</jats:sup>\n                    group (54.3%). Both overall survival (OS) and progression‐free survival (PFS) were significantly better in the ERα\n                    <jats:sup>high</jats:sup>\n                    group than in the ERα\n                    <jats:sup>low</jats:sup>\n                    group (OS, log‐rank,\n                    <jats:italic>P</jats:italic>\n                    = .0465; PFS, log‐rank,\n                    <jats:italic>P</jats:italic>\n                    = .0336). Moreover, high ERα expression on FDCs was an independent prognostic factor for OS in both the univariate ([hazard ratio] HR, 0.163;\n                    <jats:italic>P</jats:italic>\n                    = .0260) and multivariate (HR, 0.050;\n                    <jats:italic>P</jats:italic>\n                    = .0188) analyses and for PFS in both the univariate (HR, 0.232;\n                    <jats:italic>P</jats:italic>\n                    = .0213) and multivariate (HR, 0.084;\n                    <jats:italic>P</jats:italic>\n                    = .0243) analyses.\n                    <jats:italic>ERα</jats:italic>\n                    mRNA expression was detected in CD21\n                    <jats:sup>+</jats:sup>\n                    FDCs within the neoplastic follicles of FL patients. In conclusion, a neoplastic follicular microenvironment with ERα‐positive FDCs might affect the grade and presence of the follicular pattern of FL and improve patient prognosis.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751139885952","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40594338"},{"@type":"NRID","@value":"1000040594338"},{"@type":"NRID","@value":"9000384355420"},{"@type":"NRID","@value":"9000397842329"},{"@type":"NRID","@value":"9000411623961"},{"@type":"NRID","@value":"9000329014600"},{"@type":"NRID","@value":"9000290128983"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000029324"}],"foaf:name":[{"@value":"Rintaro Ohe"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007239","@type":"Researcher","foaf:name":[{"@value":"Hong‐Xue Meng"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology Harbin Medical University Cancer Hospital  Harbin China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007236","@type":"Researcher","foaf:name":[{"@value":"Akane Yamada"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007238","@type":"Researcher","foaf:name":[{"@value":"Naing Ye Aung"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007362","@type":"Researcher","foaf:name":[{"@value":"Takanobu Kabasawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007240","@type":"Researcher","foaf:name":[{"@value":"Yuka Tamura"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007233","@type":"Researcher","foaf:name":[{"@value":"Aya Utsunomiya"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007235","@type":"Researcher","foaf:name":[{"@value":"Nobuyuki Tamazawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007234","@type":"Researcher","foaf:name":[{"@value":"Ichiro Kawamura"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007360","@type":"Researcher","foaf:name":[{"@value":"Takumi Kitaoka"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007361","@type":"Researcher","foaf:name":[{"@value":"Kazushi Suzuki"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007104","@type":"Researcher","foaf:name":[{"@value":"Ryo Yanagiya"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007364","@type":"Researcher","foaf:name":[{"@value":"Tomomi Toubai"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694364565007363","@type":"Researcher","foaf:name":[{"@value":"Kenichi Ishizawa"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276160277760","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20183676"},{"@type":"NRID","@value":"1000020183676"},{"@type":"NRID","@value":"9000024260666"},{"@type":"NRID","@value":"9000384355432"},{"@type":"NRID","@value":"9000392782664"},{"@type":"NRID","@value":"9000397842330"}],"foaf:name":[{"@value":"Mitsunori Yamakawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02780232"},{"@type":"EISSN","@value":"10991069"}],"prism:publicationName":[{"@value":"Hematological Oncology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2020-04-13","prism:volume":"38","prism:number":"3","prism:startingPage":"293","prism:endingPage":"300"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhon.2730"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hon.2730"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hon.2730"},{"@id":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1002%2Fhon.2730"}],"createdAt":"2020-03-20","modifiedAt":"2023-09-04","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Estrogen%20Receptor%20alpha","dc:title":"Estrogen Receptor alpha"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Prognosis","dc:title":"Prognosis"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Survival%20Rate","dc:title":"Survival Rate"},{"@id":"https://cir.nii.ac.jp/all?q=Original%20Research%20Articles","dc:title":"Original Research Articles"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers,%20Tumor","dc:title":"Biomarkers, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Microenvironment","dc:title":"Tumor Microenvironment"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphoma,%20Follicular","dc:title":"Lymphoma, Follicular"},{"@id":"https://cir.nii.ac.jp/all?q=Dendritic%20Cells,%20Follicular","dc:title":"Dendritic Cells, Follicular"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Hybridization","dc:title":"In Situ Hybridization"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Follow-Up%20Studies","dc:title":"Follow-Up Studies"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781967867520","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K08736"},{"@type":"JGN","@value":"JP17K08736"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08736/"}],"notation":[{"@language":"ja","@value":"IgA腎症の扁桃組織におけるエストロゲン・レセプターの発現"},{"@language":"en","@value":"Expression of estrogen receptors in tonsillar tissues of IgA 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