{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361694366755347200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.hpb.2018.07.021"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1365182X18327084?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1365182X18327084?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"30170977"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma"}],"description":[{"notation":[{"@value":"Growing evidence has suggested that intrahepatic cholangiocarcinoma (iCCA) can be classified into small- and large-duct types. The present study aimed to elucidate how large-duct iCCA is similar and dissimilar to perihilar cholangiocarcinoma (pCCA).The study cohort consisted of iCCA (n = 58) and pCCA (n = 44). After iCCA tumors were separated into small- (n = 36) and large-duct (n = 22) types based on our histologic criteria, genetic statuses of the three types of neoplasms were compared. Locations of iCCA were plotted on a three-dimensional image and their distances from the portal bifurcation were measured.Large-duct iCCA was distinct from small-duct iCCA in terms of frequency of bile duct reconstruction required, perineural infiltration, and survival, with these features more similar to pCCA. Large-duct iCCA and pCCA more frequently had the loss of SMAD4 expression and MDM2 amplifications than small-duct iCCA, whereas the loss of BAP1 expression and IDH1 mutations were mostly restricted to small-duct iCCA. From imaging analysis, most tumors of large-duct iCCA were present around the second branches of the portal vein.Large-duct type iCCA shared the molecular features with pCCA, and it may be reasonable to expand the definition of pCCA to include cancers originating from the second bile duct branches."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381694366755347210","@type":"Researcher","foaf:name":[{"@value":"Masayuki Akita"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694366755347200","@type":"Researcher","foaf:name":[{"@value":"Keitaro Sofue"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694366755347205","@type":"Researcher","foaf:name":[{"@value":"Kohei Fujikura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694366755347080","@type":"Researcher","foaf:name":[{"@value":"Kyoko Otani"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694366755347332","@type":"Researcher","foaf:name":[{"@value":"Tomoo Itoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694366755347206","@type":"Researcher","foaf:name":[{"@value":"Tetsuo Ajiki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694366755347328","@type":"Researcher","foaf:name":[{"@value":"Takumi Fukumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694366755347202","@type":"Researcher","foaf:name":[{"@value":"Yoh Zen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1365182X"}],"prism:publicationName":[{"@value":"HPB"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-02","prism:volume":"21","prism:number":"2","prism:startingPage":"226","prism:endingPage":"234"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1365182X18327084?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1365182X18327084?httpAccept=text/plain"}],"createdAt":"2018-08-29","modifiedAt":"2025-10-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Amplification","dc:title":"Gene Amplification"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Prognosis","dc:title":"Prognosis"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Bile%20Duct%20Neoplasms","dc:title":"Bile Duct Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers,%20Tumor","dc:title":"Biomarkers, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Predisposition%20to%20Disease","dc:title":"Genetic Predisposition to Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Deletion","dc:title":"Gene Deletion"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Klatskin%20Tumor","dc:title":"Klatskin 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