{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361694366807171968.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.it.2019.10.007"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1471490619302169?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1471490619302169?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"31735510"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Exhausted-like Group 2 Innate Lymphoid Cells in Chronic Allergic Inflammation"}],"description":[{"notation":[{"@value":"Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or alternative functions. Subtypes can include trained (or 'memory-like') ILC2s, which recall previous allergic inflammation, inflammatory ILC2s, which acquire the ability to produce IL-17, and ex-ILC2s, which produce ILC1 cytokines. However, the functional states of ILC2s at sites of chronic or severe inflammation are not well characterized. Here, we discuss the emergence of ILC2s with 'exhausted'-like signatures, and argue that their hyporesponsiveness to stimulation and expression of inhibitory receptors is relevant in mammalian chronic allergic inflammation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381694366807171969","@type":"Researcher","foaf:name":[{"@value":"Takashi Ebihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326218086528","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20284573"},{"@type":"NRID","@value":"1000020284573"},{"@type":"NRID","@value":"9000004638043"},{"@type":"NRID","@value":"9000301734473"},{"@type":"NRID","@value":"9000401414259"},{"@type":"NRID","@value":"9000018564389"},{"@type":"NRID","@value":"9000388470634"},{"@type":"NRID","@value":"9000309989194"},{"@type":"NRID","@value":"9000249260061"},{"@type":"NRID","@value":"9000411811493"},{"@type":"NRID","@value":"9000015231477"},{"@type":"NRID","@value":"9000396104267"},{"@type":"NRID","@value":"9000404151168"},{"@type":"NRID","@value":"9000414368283"},{"@type":"NRID","@value":"9000266744880"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0117978"}],"foaf:name":[{"@value":"Ichiro Taniuchi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14714906"}],"prism:publicationName":[{"@value":"Trends in Immunology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-12","prism:volume":"40","prism:number":"12","prism:startingPage":"1095","prism:endingPage":"1104"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1471490619302169?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1471490619302169?httpAccept=text/plain"}],"createdAt":"2019-11-14","modifiedAt":"2025-10-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Clonal%20Anergy","dc:title":"Clonal Anergy"},{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Immunity,%20Innate","dc:title":"Immunity, Innate"},{"@id":"https://cir.nii.ac.jp/all?q=Th2%20Cells","dc:title":"Th2 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Hypersensitivity","dc:title":"Hypersensitivity"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Cytokines","dc:title":"Cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocytes","dc:title":"Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Transcriptome","dc:title":"Transcriptome"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781957433600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04090"},{"@type":"JGN","@value":"JP17H04090"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04090/"}],"notation":[{"@language":"ja","@value":"C末端構造を介したRunx転写因子の機構制御機構の解明"},{"@language":"en","@value":"Understanding mechanisms that regulate Runx complex function through C-terminus structures"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781993334400","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02647"},{"@type":"JGN","@value":"JP18H02647"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02647/"}],"notation":[{"@language":"ja","@value":"肺上皮細胞を介した2型自然リンパ球の数的制御機構"},{"@language":"en","@value":"Lung epithelial cells regulate ILC2 homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782015283840","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H04820"},{"@type":"JGN","@value":"JP19H04820"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04820/"}],"notation":[{"@language":"ja","@value":"ネオ・セルフ抗原認識をT細胞分化制御に転換する分子機構の解明"},{"@language":"en","@value":"Molecular mechanisms that integrate recognition of Neo-self antigen into T cell development 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Foxp3 regulate the differentiation of interleukin 17–producing T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945760877824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enforced Expression of Gata3 in T Cells and Group 2 Innate Lymphoid Cells Increases Susceptibility to Allergic Airway Inflammation in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418714997888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419120260864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419240146944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419685276672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420493396096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893559780352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895480637568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895571206784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368444579712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368892191488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor-infiltrating NY-ESO-1–specific CD8\n            <sup>+</sup>\n            T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369190373888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viral Immune Evasion Due to Persistence of Activated T Cells 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