{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361694367019013760.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.neures.2020.03.009"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0168010220301711?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0168010220301711?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"32201358"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2021172900"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin"}],"description":[{"notation":[{"@value":"In 1998, PARKIN was reported as a causal gene for hereditary recessive Parkinsonism by Kitada, Mizuno, Hattori, and Shimizu et al. Later in 2004, PINK1 was also reported as a causal gene for hereditary recessive Parkinsonism by Valente, Auburger, and Wood et al. Although many unsolved mysteries still remain, our knowledge of PINK1 and Parkin function has increased dramatically since then. Despite a number of milestone studies that advanced the PINK1 and Parkin research field, a critical turning point was undoubtedly the determination that their genuine subcellular localization was on depolarized mitochondria. In this review, we outline the key studies that have contributed to our current model for mitochondrial localization of PINK1 and Parkin. Interestingly, like two sides of a coin, our attempts to elucidate the mechanisms underlying the localization of PINK1 and Parkin were inextricably tied to the identification of the PINK1 substrate and molecular dissection of the Parkin activation mechanism."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381694367019014665","@type":"Researcher","foaf:name":[{"@value":"Noriyuki Matsuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276173040000","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30547526"},{"@type":"NRID","@value":"1000030547526"},{"@type":"NRID","@value":"9000411546186"},{"@type":"NRID","@value":"9000411103220"},{"@type":"NRID","@value":"9000370763641"},{"@type":"NRID","@value":"9000414552361"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yamano_K"}],"foaf:name":[{"@value":"Koji Yamano"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01680102"}],"prism:publicationName":[{"@value":"Neuroscience Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2020-10","prism:volume":"159","prism:startingPage":"16","prism:endingPage":"24"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0168010220301711?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0168010220301711?httpAccept=text/plain"},{"@id":"https://search.jamas.or.jp/link/ui/2021172900"}],"createdAt":"2020-03-19","modifiedAt":"2025-09-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Transport","dc:title":"Protein Transport"},{"@id":"https://cir.nii.ac.jp/all?q=Ubiquitin-Protein%20Ligases","dc:title":"Ubiquitin-Protein Ligases"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Parkinson%20Disease","dc:title":"Parkinson Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Kinases","dc:title":"Protein Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Mitochondria","dc:title":"Mitochondria"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256971658752","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H05500"},{"@type":"JGN","@value":"JP18H05500"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18H05500/"}],"notation":[{"@language":"ja","@value":"ケモテクノロジーを利用したタンパク質分解制御"},{"@language":"en","@value":"Regulation of protein degradation by chemo-technology"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256976251648","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K06237"},{"@type":"JGN","@value":"JP18K06237"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06237/"}],"notation":[{"@language":"ja","@value":"Parkinの活性化と膜移行の再構成系および素反応の解析"},{"@language":"en","@value":"Reconstitution of Parkin activation and recruitment to target membrane"}]},{"@id":"https://cir.nii.ac.jp/crid/1040566775626746752","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H05712"},{"@type":"JGN","@value":"JP19H05712"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19H05712/"}],"notation":[{"@language":"ja","@value":"多様なマイトファジーの分子機構と生理的意義の解明"},{"@language":"en","@value":"Molecular mechanism and physiological role of mitophagy"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050304183896861952","@type":"Article","resourceType":"学術雑誌論文(journal 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Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046033755776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046092132480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519083239552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519474001920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Altered cleavage and localization of PINK1 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PARL"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995955717248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996447419648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The PINK1/Parkin pathway regulates mitochondrial morphology"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468467963264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal\n                    <scp>PINK</scp>\n                    1‐dependent phosphorylation and activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469591293056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytoplasmic localization and proteasomal degradation of 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Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419779585792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419790611840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420163343616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The increasing complexity of the ubiquitin code"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420269155712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin–protein ligase with monoubiquitylation capacity"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420606787968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893292926080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The PINK1–Parkin pathway is involved in the regulation of mitochondrial remodeling process"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894328900224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Post-translational Modifications of Key Machinery in the Control of Mitophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894420991232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Building and decoding ubiquitin chains for 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