{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361694367402899328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0140-6736(19)31887-2"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0140673619318872?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0140673619318872?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"32653064"}},{"identifier":{"@type":"HANDLE","@value":"2066/215333"}},{"identifier":{"@type":"HANDLE","@value":"10281/280365"}},{"identifier":{"@type":"HANDLE","@value":"2078.1/255537"}},{"identifier":{"@type":"HANDLE","@value":"2158/1213522"}},{"identifier":{"@type":"HANDLE","@value":"10044/1/73260"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial"}],"description":[{"notation":[{"@value":"Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8-3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74-0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pIn patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk.AstraZeneca."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381694367402913923","@type":"Researcher","foaf:name":[{"@value":"Deepak L Bhatt"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694367402910473","@type":"Researcher","foaf:name":[{"@value":"Philippe Gabriel Steg"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694367402915091","@type":"Researcher","foaf:name":[{"@value":"Shamir R Mehta"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694367402911744","@type":"Researcher","foaf:name":[{"@value":"Lawrence A Leiter"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694367402911872","@type":"Researcher","foaf:name":[{"@value":"Tabassome Simon"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694367402898956","@type":"Researcher","foaf:name":[{"@value":"Kim 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