{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699993533282176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbamem.2006.03.004"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0005273606000915?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0005273606000915?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"16624255"}},{"identifier":{"@type":"NAID","@value":"30003024727"}}],"dc:title":[{"@value":"Regulation of aquaporin-2 trafficking and its binding protein complex"}],"description":[{"notation":[{"@value":"Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis. However, exact molecular mechanisms which recruit AQP2 are unknown. Recent studies highlighted a key role for spatial and temporal regulation of actin dynamics in AQP2 trafficking. We have recently identified AQP2-binding proteins which directly regulate this trafficking: SPA-1, a GTPase-activating protein (GAP) for Rap1, and cytoskeletal protein actin. In addition, a multiprotein \"force generator\" complex which directly binds to AQP2 has been discovered. This review summarizes recent advances related to the mechanism for AQP2 trafficking."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699993533282177","@type":"Researcher","foaf:name":[{"@value":"Yumi Noda"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993533282176","@type":"Researcher","foaf:name":[{"@value":"Sei Sasaki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00052736"}],"prism:publicationName":[{"@value":"Biochimica et Biophysica Acta (BBA) - Biomembranes"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2006-08","prism:volume":"1758","prism:number":"8","prism:startingPage":"1117","prism:endingPage":"1125"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0005273606000915?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0005273606000915?httpAccept=text/plain"}],"createdAt":"2006-04-01","modifiedAt":"2021-07-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Biophysics","dc:title":"Biophysics"},{"@id":"https://cir.nii.ac.jp/all?q=Diabetes%20Insipidus,%20Nephrogenic","dc:title":"Diabetes Insipidus, Nephrogenic"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Channel%20protein","dc:title":"Channel protein"},{"@id":"https://cir.nii.ac.jp/all?q=Rho","dc:title":"Rho"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclic%20AMP","dc:title":"Cyclic AMP"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Tubules,%20Collecting","dc:title":"Kidney Tubules, Collecting"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphorylation","dc:title":"Phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=Cytoskeleton","dc:title":"Cytoskeleton"},{"@id":"https://cir.nii.ac.jp/all?q=Aquaporin%202","dc:title":"Aquaporin 2"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Membrane","dc:title":"Cell Membrane"},{"@id":"https://cir.nii.ac.jp/all?q=GTPase-Activating%20Proteins","dc:title":"GTPase-Activating Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=PKA%20phosphorylation","dc:title":"PKA phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Polarity","dc:title":"Cell Polarity"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Biology","dc:title":"Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Actins","dc:title":"Actins"},{"@id":"https://cir.nii.ac.jp/all?q=Endocytosis","dc:title":"Endocytosis"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Structure,%20Tertiary","dc:title":"Protein Structure, Tertiary"},{"@id":"https://cir.nii.ac.jp/all?q=Arginine%20Vasopressin","dc:title":"Arginine Vasopressin"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Transport","dc:title":"Protein Transport"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium","dc:title":"Calcium"},{"@id":"https://cir.nii.ac.jp/all?q=Vasopressin","dc:title":"Vasopressin"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360283692363205888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706520998528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The distribution and function of aquaporins in the kidney: resolved and unresolved questions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567188091444736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Phosphorylation Regulates NCC Stability and Transporter Activity In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679308301184","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"動物のアクアポリンの多様性と比較内分泌学的展望"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307417120301312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aquaporin water channels in mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/2051151842050867584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dynamic regulation and dysregulation of the water channel aquaporin-2 : a common cause of and promising therapeutic target for water balance disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317029673984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of AQP2 water channels without vasopressin : therapeutic strategies for congenital nephrogenic diabetes insipidus"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.bbamem.2006.03.004"},{"@type":"CIA","@value":"30003024727"},{"@type":"OPENAIRE","@value":"doi_dedup___::fb99bb4bb79c947e15e98c6a4311f60d"},{"@type":"CROSSREF","@value":"10.1007/s10157-008-0118-6_references_DOI_PIHtHkm1u76tIPNOINiGVH1eaAG"},{"@type":"CROSSREF","@value":"10.1083/jcb.200709177_references_DOI_PIHtHkm1u76tIPNOINiGVH1eaAG"},{"@type":"CROSSREF","@value":"10.1007/s12565-016-0325-2_references_DOI_PIHtHkm1u76tIPNOINiGVH1eaAG"},{"@type":"CROSSREF","@value":"10.1007/s10157-013-0878-5_references_DOI_PIHtHkm1u76tIPNOINiGVH1eaAG"},{"@type":"CROSSREF","@value":"10.1681/asn.2012070742_references_DOI_PIHtHkm1u76tIPNOINiGVH1eaAG"},{"@type":"CROSSREF","@value":"10.1007/s10157-018-1544-8_references_DOI_PIHtHkm1u76tIPNOINiGVH1eaAG"},{"@type":"CROSSREF","@value":"10.5983/nl2001jsce.2007.124_4_references_DOI_PIHtHkm1u76tIPNOINiGVH1eaAG"}]}