{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699993618249088.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/wnan.1332"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fwnan.1332"}},{"identifier":{"@type":"URI","@value":"https://wires.onlinelibrary.wiley.com/doi/pdf/10.1002/wnan.1332"}}],"dc:title":[{"@value":"Applications of polymer micelles for imaging and drug delivery"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Polymeric micelles, self‐assembling nano‐constructs of amphiphilic copolymers, are widely considered as convenient nano‐carriers for a variety of applications, such as diagnostic imaging, and drug and gene delivery. They have demonstrated a variety of favorable properties including biocompatibility, longevity, high stability <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>, capacity to effectively solubilize a variety of poorly soluble drugs, changing the release profile of the incorporated pharmaceutical agents, and the ability to accumulate in the target zone based on the enhanced permeability and retention effect. Moreover, additional functions can be imparted to the micelle‐based delivery systems by engineering their surface for specific applications. Various targeting ligands can be attached for cell or intracellular accumulation at a site of interest. Also, the chelation or incorporation of imaging moieties into the micelle structure enables <jats:italic>in vivo</jats:italic> biodistribution studies. Moreover, <jats:styled-content style=\"fixed-case\">pH</jats:styled-content>‐, thermo‐, ultrasound‐, enzyme‐ and light‐sensitive block‐copolymers allow for controlled micelle dissociation and triggered drug release in response to the pathological environment‐specific stimuli and/or externally applied signals. The combination of these approaches can further improve specificity and efficacy of micelle‐based drug delivery to promote the development of smart multifunctional micelles. <jats:italic>WIREs Nanomed Nanobiotechnol</jats:italic> 2015, 7:691–707. doi: 10.1002/wnan.1332</jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Biology-Inspired Nanomaterials > Lipid-Based Structures</jats:p></jats:list-item>\n<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease</jats:p></jats:list-item>\n<jats:list-item><jats:p>Nanotechnology Approaches to Biology > Nanoscale Systems in Biology</jats:p></jats:list-item>\n</jats:list></jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699993618249090","@type":"Researcher","foaf:name":[{"@value":"Sara Movassaghian"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit MI USA"},{"@value":"Molecular Therapeutics Program Barbara Ann Karmanos Cancer Institute  Detroit MI USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993618249088","@type":"Researcher","foaf:name":[{"@value":"Olivia M. Merkel"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit MI USA"},{"@value":"Molecular Therapeutics Program Barbara Ann Karmanos Cancer Institute  Detroit MI USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993618249089","@type":"Researcher","foaf:name":[{"@value":"Vladimir P. Torchilin"}],"jpcoar:affiliationName":[{"@value":"Center for Pharmaceutical Biotechnology and Nanomedicine Northeastern University  Boston MA USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19395116"},{"@type":"EISSN","@value":"19390041"}],"prism:publicationName":[{"@value":"WIREs Nanomedicine and Nanobiotechnology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-02-13","prism:volume":"7","prism:number":"5","prism:startingPage":"691","prism:endingPage":"707"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fwnan.1332"},{"@id":"https://wires.onlinelibrary.wiley.com/doi/pdf/10.1002/wnan.1332"}],"createdAt":"2015-02-13","modifiedAt":"2023-09-25","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004239512573952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Magnetic Mixed Micelles Composed of a Non-Ionic Surfactant and Nitroxide Radicals Containing a d-Glucosamine Unit: Preparation, Stability, and Biomedical Application"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391887342464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nanoscale Self-Assemblies from Amphiphilic Block Copolymers as Proficient Templates in Drug Delivery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905608028544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567686424448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/wnan.1332"},{"@type":"CROSSREF","@value":"10.3390/pharmaceutics11010042_references_DOI_8FdcgJl89Ja5dILTxma1opKwNfO"},{"@type":"CROSSREF","@value":"10.3390/ddc2040045_references_DOI_8FdcgJl89Ja5dILTxma1opKwNfO"},{"@type":"CROSSREF","@value":"10.1021/acs.chemmater.4c02734_references_DOI_8FdcgJl89Ja5dILTxma1opKwNfO"},{"@type":"CROSSREF","@value":"10.3390/polym12081808_references_DOI_8FdcgJl89Ja5dILTxma1opKwNfO"}]}