{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699993683067904.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.tiv.2016.08.008"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0887233316301576?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0887233316301576?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"27544454"}}],"dc:title":[{"@value":"Development of yeast reporter assays for the enhanced detection of environmental ligands of thyroid hormone receptors α and β from Xenopus tropicalis"}],"description":[{"notation":[{"@value":"Thyroid hormones (THs) are involved in the regulation of metabolic homeostasis during the development and differentiation of vertebrates, particularly amphibian metamorphosis, which is entirely controlled by internal TH levels. Some artificial chemicals have been shown to exhibit TH-disrupting activities. In order to detect TH disruptors for amphibians, we herein developed a reporter assay using yeast strains expressing the thyroid hormone receptors (TRs) α and β together with the transcriptional coactivator SRC-1, all of which were derived from the frog Xenopus tropicalis (XT). These yeast strains responded to endogenous THs (T"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699993683067909","@type":"Researcher","foaf:name":[{"@value":"Satoko Matsui"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993683067910","@type":"Researcher","foaf:name":[{"@value":"Sayoko Ito-Harashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993683067906","@type":"Researcher","foaf:name":[{"@value":"Yuji Sugimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993683067904","@type":"Researcher","foaf:name":[{"@value":"Eiji Takada"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993683067908","@type":"Researcher","foaf:name":[{"@value":"Kazuhiro Shiizaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993683067907","@type":"Researcher","foaf:name":[{"@value":"Masanobu Kawanishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993683067905","@type":"Researcher","foaf:name":[{"@value":"Takashi Yagi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08872333"}],"prism:publicationName":[{"@value":"Toxicology in Vitro"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2016-12","prism:volume":"37","prism:startingPage":"15","prism:endingPage":"24"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0887233316301576?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0887233316301576?httpAccept=text/plain"}],"createdAt":"2016-09-02","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Thyroid%20Hormones","dc:title":"Thyroid Hormones"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Complementary","dc:title":"DNA, Complementary"},{"@id":"https://cir.nii.ac.jp/all?q=Xenopus","dc:title":"Xenopus"},{"@id":"https://cir.nii.ac.jp/all?q=Thyroid%20Hormone%20Receptors%20beta","dc:title":"Thyroid Hormone Receptors beta"},{"@id":"https://cir.nii.ac.jp/all?q=Saccharomyces%20cerevisiae","dc:title":"Saccharomyces cerevisiae"},{"@id":"https://cir.nii.ac.jp/all?q=Urine","dc:title":"Urine"},{"@id":"https://cir.nii.ac.jp/all?q=Toxicology","dc:title":"Toxicology"},{"@id":"https://cir.nii.ac.jp/all?q=Ligands","dc:title":"Ligands"},{"@id":"https://cir.nii.ac.jp/all?q=Feces","dc:title":"Feces"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Receptor%20Coactivator%201","dc:title":"Nuclear Receptor Coactivator 1"},{"@id":"https://cir.nii.ac.jp/all?q=Rivers","dc:title":"Rivers"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Reporter","dc:title":"Genes, Reporter"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Plasmids","dc:title":"Plasmids"},{"@id":"https://cir.nii.ac.jp/all?q=Thyroid%20Hormone%20Receptors%20alpha","dc:title":"Thyroid Hormone Receptors alpha"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335849297024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"New reporter gene assays for detecting natural and synthetic molting hormone agonists using yeasts expressing ecdysone receptors of various insects"}]},{"@id":"https://cir.nii.ac.jp/crid/1050023239833531776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of a New Reporter Gene Assay for Detecting Juvenile Hormone Agonists Using Yeast Expressing Methoprene-Tolerant of the Freshwater Cladoceran Daphnia magna"},{"@value":"Development of a New Reporter Gene Assay for Detecting Juvenile Hormone Agonists Using Yeast Expressing Methoprene‐Tolerant of the Freshwater Cladoceran <scp><i>Daphnia magna</i></scp>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339749251200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of a yeast reporter gene assay to detect ligands of freshwater cladoceran <scp><i>Daphnia magna</i></scp> ultraspiracle, a homolog of vertebrate retinoid X receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892096568704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex 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