{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699993709230464.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.0712671"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/182/5/2795/62686300/8576.pdf"}}],"dc:title":[{"@value":"Human Dendritic Cells Produce TGF-β1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+ Regulatory T Cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Dendritic cells (DCs) have a central role in the development of adaptive immune responses, including antitumor immunity. Factors present in the tumor milieu can alter the maturation of DCs and inhibit their capacity to activate T cells. Using gene expression analysis, we found that human DCs increased the expression of TGF-β1 transcripts following culture with human lung carcinoma cells (LCCs). These DCs produced increased amounts of TGF-β1 protein compared with DCs not exposed to tumor cells. LCCs also decreased the expression of CD86 and HLA-DR by immature DCs. Furthermore, LCCs decreased CD86 expression and the production of TNF-α and IL-12 p70 by mature DCs. Moreover, LCCs also converted mature DCs into cells producing TGF-β1. These TGF-β1-producing DCs were poor at eliciting the activation of naive CD4+ T cells and sustaining their proliferation and differentiation into Th1 (IFN-γ+) effectors. Instead, TGF-β1-producing DCs demonstrated an increased ability to generate CD4+CD25+Foxp3+ regulatory T cells that suppress the proliferation of T lymphocytes. These results identify a novel mechanism by which the function of human DCs is altered by tumor cells and contributes to the evasion of the immune response.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380303974012138112","@type":"Researcher","foaf:name":[{"@value":"Ingrid E Dumitriu"}],"jpcoar:affiliationName":[{"@value":"Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh , Edinburgh,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380303974012138114","@type":"Researcher","foaf:name":[{"@value":"Donald R Dunbar"}],"jpcoar:affiliationName":[{"@value":"Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh , Edinburgh,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380303974012138115","@type":"Researcher","foaf:name":[{"@value":"Sarah E Howie"}],"jpcoar:affiliationName":[{"@value":"Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh , Edinburgh,"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993709230467","@type":"Researcher","foaf:name":[{"@value":"Tariq Sethi"}],"jpcoar:affiliationName":[{"@value":"Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh , Edinburgh,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380303974012138113","@type":"Researcher","foaf:name":[{"@value":"Christopher D Gregory"}],"jpcoar:affiliationName":[{"@value":"Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh , Edinburgh,"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"15506606"},{"@type":"PISSN","@value":"00221767"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2009-03-01","prism:volume":"182","prism:number":"5","prism:startingPage":"2795","prism:endingPage":"2807"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/182/5/2795/62686300/8576.pdf"}],"createdAt":"2009-02-20","modifiedAt":"2025-03-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002220912086272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6– and IL-8–Expressing Tumors through Predominant Induction of CXCR1 by IL-6"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708516534656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"PD-L1+MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656960053888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Frequency of CD45RO+ subset in CD4+CD25high regulatory T cells associated with progression of hepatocellular carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657281000704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical significance of the frequency of regulatory T cells in regional lymph node lymphocytes as a prognostic factor for non-small-cell lung cancer"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.4049/jimmunol.0712671"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1000225_references_DOI_GGZKzWMDIgvLoNZ68oaJEKkIPON"},{"@type":"CROSSREF","@value":"10.1038/srep39296_references_DOI_GGZKzWMDIgvLoNZ68oaJEKkIPON"},{"@type":"CROSSREF","@value":"10.1016/j.canlet.2011.03.029_references_DOI_GGZKzWMDIgvLoNZ68oaJEKkIPON"},{"@type":"CROSSREF","@value":"10.1016/j.lungcan.2013.07.001_references_DOI_GGZKzWMDIgvLoNZ68oaJEKkIPON"}]}