{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699993875008000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/jps.20545"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022354916319566?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022354916319566?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"16372315"}}],"dc:title":[{"@value":"Molecular mobility of nifedipine−PVP and phenobarbital−PVP solid dispersions as measured by 13C-NMR spin-lattice relaxation time"}],"description":[{"notation":[{"@value":"Amorphous nifedipine-PVP and phenobarbital-PVP solid dispersions with various drug contents were prepared by melting and subsequent rapid cooling of mixtures of PVP and nifedipine, or phenobarbital. Chemical shifts and spin-lattice relaxation times (T(1)) of PVP, nifedipine, and phenobarbital carbons were determined by (13)C-CP/MAS NMR to elucidate drug-PVP interactions and the localized molecular mobility of drug and PVP in the solid dispersions. The chemical shift of the PVP carbonyl carbon increased as the drug content increased, appearing to reach a plateau at a molar ratio of drug to PVP monomer unit of approximately 1:1, suggesting hydrogen bond interactions between the PVP carbonyl group and the drugs. T(1) of the PVP carbonyl carbon in the solid dispersions increased as the drug content increased, indicating that the mobility of the PVP carbonyl carbon was decreased by hydrogen bond interactions. T(1) of the drug carbons increased as the PVP content increased, and this increase in T(1) became less obvious when the molar ratio of PVP monomer unit to drug exceeded approximately 1:1. These results suggest that the localized motion of the PVP pyrrolidone ring and the drug molecules is reduced by hydrogen bond interactions. Decreases in localized mobility appear to be one of the factors that stabilize the amorphous state of drugs."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699993875008000","@type":"Researcher","foaf:name":[{"@value":"Yukio Aso"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993875008001","@type":"Researcher","foaf:name":[{"@value":"Sumie Yoshioka"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00223549"}],"prism:publicationName":[{"@value":"Journal of Pharmaceutical Sciences"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2006-02","prism:volume":"95","prism:number":"2","prism:startingPage":"318","prism:endingPage":"325"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0022354916319566?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0022354916319566?httpAccept=text/plain"}],"createdAt":"2005-12-21","modifiedAt":"2019-04-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Carbon%20Isotopes","dc:title":"Carbon Isotopes"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Spectroscopy","dc:title":"Magnetic Resonance Spectroscopy"},{"@id":"https://cir.nii.ac.jp/all?q=Nifedipine","dc:title":"Nifedipine"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Conformation","dc:title":"Molecular Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Temperature","dc:title":"Temperature"},{"@id":"https://cir.nii.ac.jp/all?q=Povidone","dc:title":"Povidone"},{"@id":"https://cir.nii.ac.jp/all?q=Phenobarbital","dc:title":"Phenobarbital"},{"@id":"https://cir.nii.ac.jp/all?q=Crystallization","dc:title":"Crystallization"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233139670656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanism of Enhanced Nifedipine Dissolution by Polymer-Blended Solid Dispersion through Molecular-Level Characterization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183092932480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Application of Solid-State NMR Relaxometry for Characterization and Formulation Optimization of Grinding-Induced Drug Nanoparticle"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092421918080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Application of solid-state 13C relaxation time to prediction of the recrystallization inhibition strength of polymers on amorphous felodipine at low polymer loading"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640351852672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT® EPO"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567398626304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Correlation between drug dissolution and resistance to water-induced phase separation in solid dispersion formulations revealed by solid-state NMR spectroscopy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204169508352","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Feasibility of 19F-NMR for Assessing the Molecular Mobility of Flufenamic Acid in Solid Dispersions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679147891584","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Physical Stability of Amorphous Acetanilide Derivatives Improved by Polymer Excipients"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/jps.20545"},{"@type":"OPENAIRE","@value":"doi_dedup___::98d3103beede3e404e135cf038d273b1"},{"@type":"CROSSREF","@value":"10.1248/cpb.57.61_references_DOI_7UIKzdXX2IQW8jixV3ObXgFJYjG"},{"@type":"CROSSREF","@value":"10.1021/acs.molpharmaceut.5b00781_references_DOI_7UIKzdXX2IQW8jixV3ObXgFJYjG"},{"@type":"CROSSREF","@value":"10.1248/cpb.54.1207_references_DOI_7UIKzdXX2IQW8jixV3ObXgFJYjG"},{"@type":"CROSSREF","@value":"10.1016/j.ijpharm.2020.119300_references_DOI_7UIKzdXX2IQW8jixV3ObXgFJYjG"},{"@type":"CROSSREF","@value":"10.1007/s11095-011-0655-7_references_DOI_7UIKzdXX2IQW8jixV3ObXgFJYjG"},{"@type":"CROSSREF","@value":"10.1016/j.ijpharm.2020.119086_references_DOI_7UIKzdXX2IQW8jixV3ObXgFJYjG"},{"@type":"CROSSREF","@value":"10.1021/acs.molpharmaceut.8b00523_references_DOI_7UIKzdXX2IQW8jixV3ObXgFJYjG"}]}