{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699993950583552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/nbm.1273"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fnbm.1273"}},{"identifier":{"@type":"URI","@value":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/nbm.1273"}}],"dc:title":[{"@value":"Dynamic contrast‐enhanced MRI in the diagnosis and management of breast cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Dynamic contrast‐enhanced MRI (DCE‐MRI) is an evolving tool for determining breast disease, which benefits from the move to imaging at 3 T. It has major capabilities for the diagnosis, detection and monitoring of malignancy. It benefits from being non‐invasive and three‐dimensional, allowing visualisation of the extent of disease and its angiogenic properties, visualisation of lesion heterogeneity, detection of changes in angiogenic properties before morphological alterations, and the potential to predict the overall response either before the start of therapy or early during treatment. In addition, DCE‐MRI is emerging as a powerful tool for screening high‐risk patients and for detecting high‐grade ductal carcinoma <jats:italic>in situ</jats:italic>. However, there are also a number of limitations, including the overlap in enhancement patterns between malignant and benign disease, the failure to resolve microscopic disease particularly in the neoadjuvant setting, and the inconsistent predictive value of the enhancement pattern for clinical outcome. Careful consideration should be given to the technical requirements of individual examinations and the need for automation of post‐processing techniques to appropriately handle the growing volume of data acquired. Research continues, focusing on the use of higher field strengths with improved spatial and temporal resolution data, improving understanding of the mechanism of contrast enhancement at the cellular level, and developing macromolecular and targeted contrast agents. Copyright © 2008 John Wiley & Sons, Ltd.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699993950583552","@type":"Researcher","foaf:name":[{"@value":"Lindsay W. Turnbull"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09523480"},{"@type":"EISSN","@value":"10991492"}],"prism:publicationName":[{"@value":"NMR in Biomedicine"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2008-07-23","prism:volume":"22","prism:number":"1","prism:startingPage":"28","prism:endingPage":"39"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fnbm.1273"},{"@id":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/nbm.1273"}],"createdAt":"2008-07-23","modifiedAt":"2025-10-20","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302865547110400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumour status prediction by means of carbon-ion beam irradiation: comparison of washout rates between in-beam PET and DCE-MRI in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182334228992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Accuracy and precision of quantitative DCE-MRI parameters: How should one estimate contrast concentration?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681367743872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"乳房MRI 検査の脂肪抑制に有効なパッド素材の検討"},{"@language":"en","@value":"The Optimal Pad Material for Fat Suppression of Breast MRI"},{"@value":"臨床技術 乳房MRI検査の脂肪抑制に有効なパッド素材の検討"},{"@language":"ja-Kana","@value":"リンショウ ギジュツ チブサ MRI ケンサ ノ シボウ ヨクセイ ニ ユウコウ ナ パッド ソザイ ノ ケントウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/nbm.1273"},{"@type":"CROSSREF","@value":"10.1016/j.mri.2018.05.007_references_DOI_OYe0zM6UIDc33F9u3VJ01dHg3sd"},{"@type":"CROSSREF","@value":"10.6009/jjrt.2017_jsrt_73.8.664_references_DOI_OYe0zM6UIDc33F9u3VJ01dHg3sd"},{"@type":"CROSSREF","@value":"10.1088/1361-6560/acf438_references_DOI_OYe0zM6UIDc33F9u3VJ01dHg3sd"}]}