{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699993961867648.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1172/jci1324"}},{"identifier":{"@type":"URI","@value":"http://www.jci.org/articles/view/1324/files/pdf"}},{"identifier":{"@type":"PMID","@value":"9449694"}},{"identifier":{"@type":"NAID","@value":"30035044429"}}],"dc:title":[{"@value":"Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation."}],"description":[{"notation":[{"@value":"Carbon monoxide (CO) derived from heme oxygenase has recently been shown to play a role in controlling hepatobiliary function, but intrahepatic distribution of the enzyme is unknown. We examined distribution of two kinds of the heme oxygenase isoforms (HO-1 and HO-2) in rat liver immunohistochemically using monoclonal antibodies. The results showed that distribution of the two isoforms had distinct topographic patterns: HO-1, an inducible isoform, was observed only in Kupffer cells, while HO-2, a constitutive form, distributed to parenchymal cells, but not to Kupffer cells. Both isoforms were undetectable in hepatic stellate cells and sinusoidal endothelial cells. Of the two isoforms, HO-2 in the parenchymal cell rather than HO-1 in the Kupffer cell, appears to play a major role in regulation of microvascular tone. In the perfused liver, administration of HbO2, a CO-trapping reagent that can diffuse across the fenestrated endothelium into the space of Disse, elicited a marked sinusoidal constriction, while administration of a liposome-encapsulated Hb that cannot enter the space had no effect on the microvascular tone. These results suggest that CO evolved by HO-2 in the parenchymal cells, and, released to the extrasinusoidal space, served as the physiological relaxant for hepatic sinusoids."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1583668926194317568","@type":"Researcher","foaf:name":[{"@value":"N Goda"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993961867655","@type":"Researcher","foaf:name":[{"@value":"K Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993961867649","@type":"Researcher","foaf:name":[{"@value":"M Naito"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993961867648","@type":"Researcher","foaf:name":[{"@value":"S Takeoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993961867653","@type":"Researcher","foaf:name":[{"@value":"E Tsuchida"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993961867652","@type":"Researcher","foaf:name":[{"@value":"Y Ishimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993961867651","@type":"Researcher","foaf:name":[{"@value":"T Tamatani"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699993961867654","@type":"Researcher","foaf:name":[{"@value":"M Suematsu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219738"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00219738"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00219738"}],"prism:publicationName":[{"@value":"Journal of Clinical Investigation"}],"dc:publisher":[{"@value":"American Society for Clinical Investigation"}],"prism:publicationDate":"1998-02-01","prism:volume":"101","prism:number":"3","prism:startingPage":"604","prism:endingPage":"612"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jci.org/articles/view/1324/files/pdf"}],"createdAt":"2008-02-11","modifiedAt":"2023-08-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Carbon%20Monoxide","dc:title":"Carbon Monoxide"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=Antibodies,%20Monoclonal","dc:title":"Antibodies, Monoclonal"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Proteins","dc:title":"Membrane Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Isoenzymes","dc:title":"Isoenzymes"},{"@id":"https://cir.nii.ac.jp/all?q=Hemoglobins","dc:title":"Hemoglobins"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Heme%20Oxygenase%20(Decyclizing)","dc:title":"Heme Oxygenase (Decyclizing)"},{"@id":"https://cir.nii.ac.jp/all?q=Liposomes","dc:title":"Liposomes"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Vasoconstrictor%20Agents","dc:title":"Vasoconstrictor Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Heme%20Oxygenase-1","dc:title":"Heme Oxygenase-1"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335829992960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance"},{"@value":"Haem-dependent dimerization of PGMC1/SIGMA-2 receptor facilitates cancer proliferation and chemoresistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1050001337399322624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"網膜におけるNO, 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