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There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat various diseases driven by prolonged ER stress. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994064949888","@type":"Researcher","foaf:name":[{"@value":"Lale Ozcan"}],"jpcoar:affiliationName":[{"@value":"Departments of 1Medicine,"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994064949889","@type":"Researcher","foaf:name":[{"@value":"Ira Tabas"}],"jpcoar:affiliationName":[{"@value":"Departments of 1Medicine,"},{"@value":"Pathology & Cell Biology, and"},{"@value":"Physiology & Cellular Biophysics, Columbia University, New York, New York 10032;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00664219"},{"@type":"EISSN","@value":"1545326X"}],"prism:publicationName":[{"@value":"Annual Review of Medicine"}],"dc:publisher":[{"@value":"Annual 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