{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994121469568.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1408355111"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1408355111"}}],"dc:title":[{"@value":"DNA methylation of BDNF as a biomarker of early-life adversity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Early-life adversity increases the risk for psychopathology in later life. The underlying mechanism(s) is unknown, but epigenetic variation represents a plausible candidate. Early-life exposures can disrupt epigenetic programming in the brain, with lasting consequences for gene expression and behavior. This evidence is primarily derived from animal studies, with limited study in humans due to inaccessibility of the target brain tissue. In humans, although there is evidence for DNA methylation changes in the peripheral blood of psychiatric patients, a fundamental question remains as to whether epigenetic markers in the blood can predict epigenetic changes occurring in the brain. We used in utero bisphenol A (BPA) exposure as a model environmental exposure shown to disrupt neurodevelopment and exert long-term effects on behavior in animals and humans. We show that prenatal BPA induces lasting DNA methylation changes in the transcriptionally relevant region of the\n            <jats:italic>Bdnf</jats:italic>\n            gene in the hippocampus and blood of BALB/c mice and that these changes are consistent with\n            <jats:italic>BDNF</jats:italic>\n            changes in the cord blood of humans exposed to high maternal BPA levels in utero. Our data suggest that\n            <jats:italic>BDNF</jats:italic>\n            DNA methylation in the blood may be used as a predictor of brain\n            <jats:italic>BDNF</jats:italic>\n            DNA methylation and gene expression as well as behavioral vulnerability induced by early-life environmental exposure. Because\n            <jats:italic>BDNF</jats:italic>\n            expression and DNA methylation are altered in several psychiatric disorders that are associated with early-life adversity, including depression, schizophrenia, bipolar disorder, and autism,\n            <jats:italic>BDNF</jats:italic>\n            DNA methylation in the blood may represent a novel biomarker for the early detection of psychopathology.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994121469570","@type":"Researcher","foaf:name":[{"@value":"Marija Kundakovic"}],"jpcoar:affiliationName":[{"@value":"Department of Psychology, Columbia University, New York, NY 10027; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994121469569","@type":"Researcher","foaf:name":[{"@value":"Kathryn Gudsnuk"}],"jpcoar:affiliationName":[{"@value":"Department of Psychology, Columbia University, New York, NY 10027; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994121469568","@type":"Researcher","foaf:name":[{"@value":"Julie B. Herbstman"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994121469571","@type":"Researcher","foaf:name":[{"@value":"Deliang Tang"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994121469572","@type":"Researcher","foaf:name":[{"@value":"Frederica P. Perera"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994121469573","@type":"Researcher","foaf:name":[{"@value":"Frances A. Champagne"}],"jpcoar:affiliationName":[{"@value":"Department of Psychology, Columbia University, New York, NY 10027; and"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2014-11-10","prism:volume":"112","prism:number":"22","prism:startingPage":"6807","prism:endingPage":"6813"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1408355111"}],"createdAt":"2014-11-11","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235811535360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"DNA methylation analyses of the candidate genes identified by a methylome‐wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016864728376064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693653252736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617474577792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643766518656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Short‐term running exercise alters DNA methylation patterns in neuronal nitric oxide synthase and brain‐derived neurotrophic factor genes in the mouse hippocampus and reduces anxiety‐like behaviors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184718684544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aberrant Epigenetic Gene Regulation in GABAergic Interneuron Subpopulations in the Hippocampal Dentate Gyrus of Mouse Offspring Following Developmental Exposure to Hexachlorophene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092642509184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<p>Interrelation Between Increased BDNF Gene Methylation and High Sociotropy, a Personality Vulnerability Factor in Cognitive Model of Depression</p>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661799324544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664411642368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prader-Willi Syndrome: The Disease that Opened up Epigenomic-Based Preemptive Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567357944192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567530881920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707143430912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence"}]},{"@id":"https://cir.nii.ac.jp/crid/1360866730491565824","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synaptic control of DNA-methylation involves activity-dependent degradation of DNMT3a1 in the nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367059425536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus？ : an analysis using a high-sensitivity methylome technique"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.1408355111"},{"@type":"CROSSREF","@value":"10.1111/pcn.12645_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1007/s11064-022-03594-0_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1155/2017/7526592_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.3390/ijms21155564_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1096/fj.202100630r_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1093/toxsci/kfx291_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.2147/ndt.s252177_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1186/s41021-018-0099-y_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.3390/diseases4010015_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1038/s41386-020-0780-2_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1038/s41598-020-80390-2_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0270144_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1101/602151_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"},{"@type":"CROSSREF","@value":"10.1192/bjpo.bp.115.001586_references_DOI_NCSpAkNyVz0DRvR2RVgfPQGZyab"}]}