{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994156827136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/anie.201805501"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201805501"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201805501"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.201805501"}}],"dc:title":[{"@value":"Chemistry for Positron Emission Tomography: Recent Advances in <sup>11</sup>C‐, <sup>18</sup>F‐, <sup>13</sup>N‐, and <sup>15</sup>O‐Labeling Reactions"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron‐emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on <jats:sup>11</jats:sup>C, <jats:sup>18</jats:sup>F, <jats:sup>13</jats:sup>N, and <jats:sup>15</jats:sup>O.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994156827137","@type":"Researcher","foaf:name":[{"@value":"Xiaoyun Deng"}],"jpcoar:affiliationName":[{"@value":"Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School  Boston MA 02114 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994156827138","@type":"Researcher","foaf:name":[{"@value":"Jian Rong"}],"jpcoar:affiliationName":[{"@value":"Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School  Boston MA 02114 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994156827264","@type":"Researcher","foaf:name":[{"@value":"Lu Wang"}],"jpcoar:affiliationName":[{"@value":"Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School  Boston MA 02114 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994156827266","@type":"Researcher","foaf:name":[{"@value":"Neil Vasdev"}],"jpcoar:affiliationName":[{"@value":"Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School  Boston MA 02114 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994156827136","@type":"Researcher","foaf:name":[{"@value":"Lei Zhang"}],"jpcoar:affiliationName":[{"@value":"Medicine Design Pfizer Inc.  Cambridge MA 02139 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994156827265","@type":"Researcher","foaf:name":[{"@value":"Lee Josephson"}],"jpcoar:affiliationName":[{"@value":"Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School  Boston MA 02114 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994156827267","@type":"Researcher","foaf:name":[{"@value":"Steven H. Liang"}],"jpcoar:affiliationName":[{"@value":"Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School  Boston MA 02114 USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14337851"},{"@type":"EISSN","@value":"15213773"}],"prism:publicationName":[{"@value":"Angewandte Chemie International Edition"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-01-14","prism:volume":"58","prism:number":"9","prism:startingPage":"2580","prism:endingPage":"2605"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201805501"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201805501"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.201805501"}],"createdAt":"2018-07-28","modifiedAt":"2023-09-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017279848089472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025429407065344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Quantitative Generation of HF from KF and Formation of Amine‐3HF Complexes by Using Cation Exchange Reaction Between KF and Amberlyst 15DRY"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286992972123904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design, Synthesis, and Evaluation of <sup>18</sup>F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617793807488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118716561920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118771870336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118787689216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Imaging the trace amine-associated receptor 1 by positron emission tomography"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232396781440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588379378482688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of a Candidate <sup>11</sup>C-Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567746706944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled  -amino acid oxidase (DAAO) inhibitor for PET imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593748257664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent developments on PET radiotracers for TSPO and their applications in neuroimaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861289646797568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rapid ‘on-column’ preparation of hydrogen [<sup>11</sup>C]cyanide from [<sup>11</sup>C]methyl iodide <i>via</i> [<sup>11</sup>C]formaldehyde"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816800474240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of Novel <sup>11</sup>C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855133504512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Radiosynthesis and evaluation of novel 18F labeled PET ligands for imaging monoacylglycerol lipase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855582314368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Radiosynthesis and preclinical evaluation of a carbon-11 labeled PET ligand for imaging metabotropic glutamate receptor 7"}]},{"@id":"https://cir.nii.ac.jp/crid/1390018594844146816","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Design and Synthetic Strategy toward Development of PET Probes"},{"@language":"ja","@value":"PETプローブ開発を指向した分子設計と合成戦略"},{"@language":"ja-Kana","@value":"PET プローブ カイハツ オ シコウ シタ ブンシ セッケイ ト ゴウセイ センリャク"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/anie.201805501"},{"@type":"CROSSREF","@value":"10.1021/acs.jmedchem.9b00936_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1038/s41401-022-00912-8_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1002/chem.202500789_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1038/s41401-020-0456-9_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1186/s41181-021-00138-9_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1016/j.tetlet.2020.152060_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1016/j.tetlet.2021.153007_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1021/acs.jmedchem.2c00377_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.82.433_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1021/acsomega.4c03214_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2020.127326_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1016/j.apsb.2020.08.006_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1039/d1sc07033a_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1021/acsmedchemlett.3c00320_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.1016/j.ejmech.2025.117246_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"},{"@type":"CROSSREF","@value":"10.62347/puai9230_references_DOI_MigaMXXUHaR5lJVVX8oDEIg3abI"}]}