{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994175591680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/hep.21249"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.21249"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/01515467-200608000-00007"}},{"identifier":{"@type":"PMID","@value":"16871568"}},{"identifier":{"@type":"NAID","@value":"30015138621"}}],"dc:title":[{"@value":"Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title/>\n            <jats:p>\n                                 <jats:bold>The outcome of acute hepatitis B virus (HBV) infection is variable, influenced by host and viral factors. From 1982 through 2004, 301 patients with acute HBV infection entered a multi-center cross-sectional study in Japan. Patients with fulminant hepatitis (n = 40) were older (44.7 ± 16.3 vs. 36.0 ± 14.3 years,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>< .0017), less predominantly male (43% vs. 71%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>= .0005), less positive for hepatitis B e antigen (HBeAg) (23% vs. 60%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>< .0001), less infected with subgenotype Ae (0% vs. 13%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>< .05), and more frequently with Bj (30% vs. 4%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>< .0001) than those with acute self-limited hepatitis (n = 261). Precore (G1896A) and core-promoter (A1762T/G1764A) mutations were more frequent in patients with fulminant than acute self-limited hepatitis (53% vs. 9% and 50% vs. 17%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>< .0001 for both). HBV infection persisted in only three (1%) patients, and they represented 2 of the 23 infected with Ae and 1 of the 187 with the other subgenotypes (9% vs. 0.5%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>= .032); none of them received antiviral therapy. In multivariate analysis, age 34 years or older, Bj, HBeAg-negative, total bilirubin 10.0 mg/dL or greater, and G1896A mutation were independently associated with the fulminant outcome. In</jats:bold>\n                                 <jats:bold>\n                                    in vitro\n                                 </jats:bold>\n                                 <jats:bold>transfection experiments, the replication of Bj clone was markedly enhanced by introducing either G1896A or A1762T/G1764A mutation.</jats:bold>\n                                 <jats:bold>\n                                    In conclusion\n                                 </jats:bold>\n                                 <jats:bold>, persistence of HBV was rare (1%) and associated with Ae, whereas fulminant hepatitis was frequent (13%) and associated with Bj and lack of HBeAg as well as high replication due to precore mutation in patients with acute HBV infection.</jats:bold>\n                                 <jats:bold>\n                                    Supplementary material for this article can be found on the HEPATOLOGY website\n                                 </jats:bold> (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html).</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994175591680","@type":"Researcher","foaf:name":[{"@value":"Atsushi Ozasa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591809","@type":"Researcher","foaf:name":[{"@value":"Yasuhito Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591812","@type":"Researcher","foaf:name":[{"@value":"Etsuro Orito"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751148695808","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20612427"},{"@type":"NRID","@value":"1000020612427"},{"@type":"ORCID","@value":"0000-0002-9084-7197"},{"@type":"NRID","@value":"9000004091620"},{"@type":"NRID","@value":"9000408585344"},{"@type":"NRID","@value":"9000408998077"},{"@type":"NRID","@value":"9000257777112"},{"@type":"NRID","@value":"9000018576733"},{"@type":"NRID","@value":"9000257777387"},{"@type":"NRID","@value":"9000021458005"},{"@type":"NRID","@value":"9000257924513"},{"@type":"NRID","@value":"9000257924555"},{"@type":"NRID","@value":"9000241432081"},{"@type":"NRID","@value":"9000367827818"},{"@type":"NRID","@value":"9000021329116"},{"@type":"NRID","@value":"9000290132745"},{"@type":"NRID","@value":"9000362198498"},{"@type":"NRID","@value":"9000016968039"},{"@type":"NRID","@value":"9000367827762"},{"@type":"NRID","@value":"9000002026558"},{"@type":"NRID","@value":"9000309185464"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/msugiyama08"}],"foaf:name":[{"@value":"Masaya Sugiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591682","@type":"Researcher","foaf:name":[{"@value":"Jong-Hon Kang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591686","@type":"Researcher","foaf:name":[{"@value":"Shuhei Hige"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591683","@type":"Researcher","foaf:name":[{"@value":"Tomoyuki Kuramitsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591813","@type":"Researcher","foaf:name":[{"@value":"Kazuyuki Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591554","@type":"Researcher","foaf:name":[{"@value":"Eiji Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591681","@type":"Researcher","foaf:name":[{"@value":"Shunichi Okada"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591689","@type":"Researcher","foaf:name":[{"@value":"Hajime Tokita"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591687","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Asahina"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591693","@type":"Researcher","foaf:name":[{"@value":"Kazuaki Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591810","@type":"Researcher","foaf:name":[{"@value":"Shinichi Kakumu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591691","@type":"Researcher","foaf:name":[{"@value":"Takeshi Okanoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591553","@type":"Researcher","foaf:name":[{"@value":"Yoshikazu Murawaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591811","@type":"Researcher","foaf:name":[{"@value":"Keisuke Hino"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591685","@type":"Researcher","foaf:name":[{"@value":"Morikazu Onji"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591684","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Yatsuhashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591808","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Sakugawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591552","@type":"Researcher","foaf:name":[{"@value":"Yuzo Miyakawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591692","@type":"Researcher","foaf:name":[{"@value":"Ryuzo Ueda"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994175591690","@type":"Researcher","foaf:name":[{"@value":"Masashi Mizokami"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02709139"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/02709139"}],"prism:publicationName":[{"@value":"Hepatology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2006-08","prism:volume":"44","prism:number":"2","prism:startingPage":"326","prism:endingPage":"334"},"reviewed":"false","dc:rights":["http://doi.wiley.com/10.1002/tdm_license_1.1"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.21249"},{"@id":"https://journals.lww.com/01515467-200608000-00007"}],"createdAt":"2006-07-26","modifiedAt":"2024-12-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20virus","dc:title":"Hepatitis B virus"},{"@id":"https://cir.nii.ac.jp/all?q=Genotype","dc:title":"Genotype"},{"@id":"https://cir.nii.ac.jp/all?q=Radioimmunoassay","dc:title":"Radioimmunoassay"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme-Linked%20Immunosorbent%20Assay","dc:title":"Enzyme-Linked Immunosorbent Assay"},{"@id":"https://cir.nii.ac.jp/all?q=Virus%20Replication","dc:title":"Virus Replication"},{"@id":"https://cir.nii.ac.jp/all?q=Polymerase%20Chain%20Reaction","dc:title":"Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20e%20Antigens","dc:title":"Hepatitis B e Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Retrospective%20Studies","dc:title":"Retrospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Incidence","dc:title":"Incidence"},{"@id":"https://cir.nii.ac.jp/all?q=Viral%20Core%20Proteins","dc:title":"Viral Core Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B","dc:title":"Hepatitis B"},{"@id":"https://cir.nii.ac.jp/all?q=Prognosis","dc:title":"Prognosis"},{"@id":"https://cir.nii.ac.jp/all?q=Cross-Sectional%20Studies","dc:title":"Cross-Sectional Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Acute%20Disease","dc:title":"Acute Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Chronic%20Disease","dc:title":"Chronic Disease"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Viral","dc:title":"DNA, Viral"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Follow-Up%20Studies","dc:title":"Follow-Up Studies"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050851497147435648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"B型肝炎ウイルスの変異と病態"},{"@language":"ja-Kana","@value":"Bガタ カンエン ウイルス ノ ヘンイ ト ビョウタイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216004487296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002220988374656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt"}]},{"@id":"https://cir.nii.ac.jp/crid/1360003447272107008","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Comparison of hepatitis B vaccine efficacy in Japanese students: a retrospective study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230126765056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230127107328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Strategy for preventing hepatitis B reactivation in patients with resolved hepatitis B virus infection after rituximab-containing chemotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232280833152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reactivation from occult HBV carrier status is characterized by low genetic heterogeneity with the wild-type or G1896A variant prevalence"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234473604352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235757163264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Management of hepatitis B: Consensus of the Japan Society of Hepatology 2009"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235779380096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005516525941632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Impact of Rapid Evolution of Hepatitis Viruses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142744714496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of HBV immune evasion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168820559232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Blood-Based Biomarkers in Hepatitis B Virus-Related Hepatocellular Carcinoma, Including the Viral Genome and Glycosylated Proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168879457536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The association between hepatocarcinogenesis and intracellular alterations due to hepatitis B virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706238094848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Virological and Clinical Characteristics of Hepatitis B Virus Genotype A"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710501032064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel hepatitis <scp>B</scp> virus strain developing due to recombination between genotypes <scp>H</scp> and <scp>B</scp> strains isolated from a <scp>J</scp>apanese patient"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168116348928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"JSH Guidelines for the Management of Hepatitis B Virus Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180080471936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183036660352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prevalence and epidemiological traits of HIV infections in populations with high-risk behaviours as revealed by genetic analysis of HBV"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185399486080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Causes of vertical transmission of hepatitis B virus under the at‐risk prevention strategy in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185399496832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Specific mutations of basal core promoter are associated with chronic liver disease in hepatitis B virus subgenotype D1 prevalent in Turkey"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185478217984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fatal reactivation of hepatitis B virus infection in a patient with adult T‐cell leukemia–lymphoma receiving the anti‐CC chemokine receptor 4 antibody mogamulizumab"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642463453952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Monitoring of Hepatitis B Virus (HBV) DNA and Risk of HBV Reactivation in B-Cell Lymphoma: A Prospective Observational Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655117244800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Virological and clinical characteristics on reactivation of occult hepatitis B in patients with hematological malignancy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655117371520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Multiple intra‐familial transmission patterns of hepatitis B virus genotype D in north‐eastern Egypt"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655117702784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Shifting hepatitis B virus genotypes of acute hepatitis B patients in northeast Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659540475904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced Replication of Hepatitis B Virus With Frameshift in the Precore Region Found in Fulminant Hepatitis Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659861074176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660454528128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estimating numbers of persons with persistent hepatitis <scp>B</scp> virus infection transmitted vertically and horizontally in the birth cohort during 1950–1985 in <scp>J</scp>apan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660454817024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immunobiology of hepatitis <scp>B</scp> virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660724580352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanism of the dependence of hepatitis B virus genotype G on co‐infection with other genotypes for viral replication"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593720505216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Virus-Driven Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816811828352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869856037708672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Long-read deep sequencing analysis of hepatitis B virus quasispecies in two elderly cases of interspousal transmission"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975841508151424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel stable HBV producing cell line systems for expression and screening antiviral inhibitor of hepatitis B virus in human hepatoma cell line"}]},{"@id":"https://cir.nii.ac.jp/crid/1363101969001210880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hepatitis B Virus Genotype-Dependent Vulnerability of Infected Cells to Immune Reaction in the Early Phase of Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204792621056","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A case of acute hepatitis B by HBV genotype E"},{"@language":"ja","@value":"Ｇｅｎｏｔｙｐｅ　ＥによるＢ型急性肝炎の１例"},{"@value":"症例報告 Genotype EによるB型急性肝炎の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク Genotype E ニ ヨル Bガタ キュウセイ カンエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204792912128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Universal hepatitis B vaccination: pros and cons"},{"@language":"ja","@value":"ユニバーサルＨＢワクチネーション：是か非か？"},{"@language":"ja-Kana","@value":"ユニバーサル HB ワクチネーション ゼ カ ヒ カ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204792984064","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"日本肝臓学会コンセンサス神戸2009：C型肝炎の診断と治療"},{"@language":"en","@value":"JSH Consensus Kobe 2009: Diagnosis and Treatment of Hepatitis C"},{"@language":"ja-Kana","@value":"ニホン カンゾウ ガッカイ コンセンサス コウベ 2009 Cガタ カンエン ノ シンダン ト チリョウ"},{"@value":"日本肝臓学会コンセンサス神戸2009--B型肝炎の診断と治療"},{"@language":"ja-Kana","@value":"ニホン カンゾウ ガッカイ コンセンサス コウベ 2009 Bガタ カンエン ノ シンダン ト チリョウ"},{"@value":"JSH Consensus Kobe 2009: Diagnosis and Treatment of Hepatitis B"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204794520320","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transition and problems of hepatitis B virus genotypes among patients with acute and chronic infection in Japan"},{"@language":"ja","@value":"わが国におけるB型肝炎ウィルス遺伝子型の変遷と問題点"},{"@value":"Editorial わが国におけるB型肝炎ウィルス遺伝子型の変遷と問題点"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル Bガタ カンエン ウィルス イデンシガタ ノ ヘンセン ト モンダイテン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204795693056","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distribution of hepatitis B viral genotypes in Japan"},{"@language":"ja","@value":"わが国におけるB型肝炎ウイルス遺伝子型の分布"},{"@value":"Editorial わが国におけるB型肝炎ウイルス遺伝子型の分布"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル Bガタ カンエン ウイルス イデンシガタ ノ ブンプ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204870288512","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An Adult Patient with Acute Infection with Hepatitis B Virus Genotype C that Progressed to Chronic Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204870909184","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lamivudine Treatment Improves the Prognosis of Fulminant Hepatitis B"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204874520448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Ｂ型肝炎ウイルスＧｅｎｏｔｙｐｅ／ｓｕｂｇｅｎｏｔｙｐｅ"},{"@language":"en","@value":"Hepatitis B virus genotype/subgenotype"},{"@value":"キーワード B型肝炎ウイルス Genotype/subgenotype"},{"@language":"ja-Kana","@value":"キーワード Bガタ カンエン ウイルス Genotype subgenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205078952960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reverse Genetics of Hepatitis B virus"},{"@language":"ja","@value":"B型肝炎ウイルス （HBV）のリバースジェネティックス"},{"@language":"ja-Kana","@value":"Bガタ カンエンウイルス(HBV)ノ リバースジェネティックス"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679765858688","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent trends in acute hepatitis B in Japan"},{"@language":"ja","@value":"我国に於ける急性B型肝炎の最近の動向"},{"@value":"Editorial 我国に於ける急性B型肝炎の最近の動向"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル キュウセイ Bガタ カンエン ノ サイキン ノ ドウコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771053440","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A case of acute hepatitis B associated with secondary syphilis"},{"@language":"ja","@value":"皮膚梅毒を合併したＧｅｎｏｔｙｐｅ　Ａ，Ｂ型急性肝炎の１例"},{"@value":"症例報告 皮膚梅毒を合併したGenotype A,B型急性肝炎の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク ヒフ バイドク オ ガッペイ シタ Genotype A Bガタ キュウセイ カンエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771619840","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two cases of acute hepatitis due to hepatitis E virus that are indigenous to Kitakyushu: a case report"},{"@language":"ja","@value":"北九州に土着したE型肝炎ウイルス株による急性肝炎の2例"},{"@value":"B型肝炎治療ガイドライン(第1.1版)"},{"@language":"ja-Kana","@value":"Bガタ カンエン チリョウ ガイドライン(ダイ1.1ハン)"},{"@language":"ja-Kana","@value":"キタキュウシュウ ニ ドチャク シタ Eガタ カンエンウイルスカブ ニ ヨル キュウセイ カンエン ノ 2レイ"},{"@value":"Guidelines for the management of hepatitis B virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679772125184","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gianotti-Crosti syndrome associated with hepatitis B virus (HBV) infection in an adult: a case report"},{"@language":"ja","@value":"成人発症のＢ型肝炎ウイルスに関連したＧｉａｎｏｔｔｉ－Ｃｒｏｓｔｉ症候群の１例"},{"@value":"症例報告 成人発症のB型肝炎ウイルスに関連したGianotti-Crosti症候群の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク セイジン ハッショウ ノ Bガタ カンエン ウイルス ニ カンレン シタ Gianotti Crosti ショウコウグン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680054555392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Direct cytopathic effects of particular hepatitis B virus genotypes in immunosuppressive condition"},{"@language":"ja","@value":"Ｂ型肝炎ウイルス感染による肝細胞傷害の機序～ＨＢＶ遺伝子型と病原性～"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681377615360","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"B型肝炎の治療-遺伝子型と治療について-"},{"@language":"en","@value":"Therapy for chronic hepatitis B: relationship between HBV genotype and efficacy or resistance of anti-viral therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390566775140586496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fulminant Hepatitis due to <i>de novo</i> Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845702298943232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acute Liver Failure Caused by the Transmission of Hepatitis B Virus from the Spouse after 38 Years of Marriage"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845713015745920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1523106605811692544","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"B型肝炎ウイルス感染による肝細胞傷害の機序--HBV遺伝子型と病原性"},{"@language":"ja-Kana","@value":"Bガタ カンエン ウイルス カンセン ニ ヨル カン サイボウ ショウガイ ノ キジョ HBV イデンシガタ ト ビョウゲンセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750919124224","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"B型肝炎ウイルス"},{"@language":"en","@value":"Immune response and tolerance in hepatitis B virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226062708096","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"HIV感染者のB型急性肝炎重症化に対するエンテカビル投与によりHIV-RNA量の著明な低下を認めた1例"},{"@language":"en","@value":"A case of HIV coinfected with hepatitis B virus treated by entecavir"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700414893824","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immunoprophylaxis of perinatal infection with hepatitis B virus on the national scale"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176220897920","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Geographical and genetic diversity of the human hepatitis B virus"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650346194944","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650357675648","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600424185856","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Japanese case of hepatitis B virus genotypes C/D hybrid"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601151591936","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Factors involved in the development of fulminant hepatitis B : Are the mutations of hepatitis B virus implicated?"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075410419712","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prevention of hepatitis B virus infection by vaccination : Progress and problems"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025436940544","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974833750400","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reactivation of hepatitis B virus following rituximab-plus-steroid combination chemotherapy"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/hep.21249"},{"@type":"CIA","@value":"30015138621"},{"@type":"OPENAIRE","@value":"doi_dedup___::da2b441abfc5c541d0028b045ccb9b2b"},{"@type":"CROSSREF","@value":"10.4254/wjh.v9.i9.477_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1186/s12199-019-0837-1_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1002/hep.25651_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1002/hep.26963_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/j.1872-034x.2010.00739.x_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/jgh.13030_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.4190-19_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.47.1061_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2018.02.175_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.51.615_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.51.6142_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.4044/joma.119.205_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1016/j.antiviral.2020.104816_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.0977-18_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.3390/ijms222011051_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/liv.15065_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1007/s00535-017-1367-5_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/hepr.12238_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.51.163_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.51.243_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.50.269_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1016/b978-0-12-374153-0.00015-1_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/hepr.12269_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1002/hep.26635_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1017/s0950268812003123_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/1348-0421.12009_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/1348-0421.12011_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/hepr.12513_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.51.107_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.49.549_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1016/j.jhep.2014.04.033_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1093/cid/civ344_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1002/jmv.21995_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1002/jmv.23234_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1002/jmv.24309_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1093/infdis/jir485_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1099/jgv.0.000566_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/hepr.12288_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/hepr.12439_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1111/jvh.12022_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.50.598_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.54.402_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2957/kanzo.47.419_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2222/jsv.63.23_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2222/jsv.60.79_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1016/j.jcv.2012.06.011_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.3390/cancers13112625_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1097/hep.0000000000000335_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1016/j.jiac.2024.09.010_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.3028-19_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.3389/fmicb.2019.02427_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"},{"@type":"CROSSREF","@value":"10.1089/aid.2014.0281_references_DOI_6TUECtPE1QJBJU8TS7pd05sFGUT"}]}