{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994193706240.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/apt.12038"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapt.12038"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/apt.12038"}}],"dc:title":[{"@value":"Non‐alcoholic fatty liver disease (<scp>NAFLD</scp>) is associated with low level of physical activity: a population‐based study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>High intensity exercise improves metabolic status and may potentially mobilise hepatic fat.</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>To assess the level of physical activity (<jats:styled-content style=\"fixed-case\">PA</jats:styled-content>) of subjects with non‐alcoholic fatty liver disease <jats:styled-content style=\"fixed-case\">(NAFLD</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Data were obtained from <jats:styled-content style=\"fixed-case\">NHANES</jats:styled-content> (2003–2006). Activity counts obtained from accelerometer readings (ActiGraph, Fort Walton Beach, <jats:styled-content style=\"fixed-case\">FL</jats:styled-content>), from 7 consecutive days quantified total<jats:styled-content style=\"fixed-case\"> PA</jats:styled-content> and time spent engaged in different levels of activity. All measures were counts/minutes/day: (sedentary <100; light 100–0027; moderate, 2020–5999 and vigorous, 6000+). <jats:styled-content style=\"fixed-case\">NAFLD</jats:styled-content> was defined as a fatty liver index >60 (<jats:styled-content style=\"fixed-case\">FLI</jats:styled-content>) in the absence of other chronic liver disease. Subjects with <jats:styled-content style=\"fixed-case\">NAFLD</jats:styled-content> were compared to controls using stratum‐specific Chi‐squared and <jats:italic>t</jats:italic>‐tests. Simple linear regression analyses (with Taylor series linearised variance estimation and weighting) were used to determine the association between <jats:styled-content style=\"fixed-case\">PA</jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">NAFLD</jats:styled-content>. <jats:italic>P</jats:italic>‐values <0.05 were considered significant. Statistical analyses were conducted using <jats:sc>sudaan</jats:sc> version 10.1 and <jats:sc>sas</jats:sc> version 9.1.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We included 3056 participants. <jats:styled-content style=\"fixed-case\">NAFLD</jats:styled-content> patients were older, had higher BMI, larger waist circumference, higher sum of skinfolds, more likely to have insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA</jats:styled-content> > 3.0) and type‐2 diabetes (all <jats:italic>P</jats:italic>‐values <0.01). Average <jats:styled-content style=\"fixed-case\">PA</jats:styled-content> for <jats:styled-content style=\"fixed-case\">NAFLD</jats:styled-content> subjects was about 28.7 counts/minute/day less than controls (<jats:italic>P</jats:italic> < 0.01). Furthermore, <jats:styled-content style=\"fixed-case\">NAFLD</jats:styled-content> subjects spent less time participating in activity at any level (<jats:italic>P</jats:italic> < 0.01). Subjects with <jats:styled-content style=\"fixed-case\">NAFLD</jats:styled-content> and <jats:styled-content style=\"fixed-case\">DM</jats:styled-content> were in the lowest quartile of average <jats:styled-content style=\"fixed-case\">PA</jats:styled-content> as well as moderate‐vigorous <jats:styled-content style=\"fixed-case\">PA</jats:styled-content> (<jats:italic>P</jats:italic> < 0.01).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Data from this study show that non‐alcoholic fatty liver disease patients have low level of physical activity and, when they have <jats:styled-content style=\"fixed-case\">diabetes mellitus</jats:styled-content>, they perform at the lowest quartile of <jats:styled-content style=\"fixed-case\">physical activity</jats:styled-content> and moderate‐vigorous physical activity.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380009142794095374","@type":"Researcher","foaf:name":[{"@value":"L. Gerber"}],"jpcoar:affiliationName":[{"@value":"Center for Liver Diseases  Inova Fairfax Hospital  Falls Church  VA  USA"},{"@value":"Betty and Guy Beatty Center for Integrated Research  Inova Health System  Falls Church  VA  USA"},{"@value":"Center for the Study of Chronic Illness and Disability George Mason University  Fairfax  VA  USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994193706240","@type":"Researcher","foaf:name":[{"@value":"M. Otgonsuren"}],"jpcoar:affiliationName":[{"@value":"Center for Liver Diseases  Inova Fairfax Hospital  Falls Church  VA  USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994193706246","@type":"Researcher","foaf:name":[{"@value":"A. Mishra"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine  Inova Fairfax Hospital  Falls Church  VA  USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994193706244","@type":"Researcher","foaf:name":[{"@value":"C. Escheik"}],"jpcoar:affiliationName":[{"@value":"Center for Liver Diseases  Inova Fairfax Hospital  Falls Church  VA  USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994193706243","@type":"Researcher","foaf:name":[{"@value":"A. Birerdinc"}],"jpcoar:affiliationName":[{"@value":"Center for Liver Diseases  Inova Fairfax Hospital  Falls Church  VA  USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994193706241","@type":"Researcher","foaf:name":[{"@value":"M. Stepanova"}],"jpcoar:affiliationName":[{"@value":"Center for Liver Diseases  Inova Fairfax Hospital  Falls Church  VA  USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994193706242","@type":"Researcher","foaf:name":[{"@value":"Z. M. Younossi"}],"jpcoar:affiliationName":[{"@value":"Center for Liver Diseases  Inova Fairfax Hospital  Falls Church  VA  USA"},{"@value":"Betty and Guy Beatty Center for Integrated Research  Inova Health System  Falls Church  VA  USA"},{"@value":"Department of Medicine  Inova Fairfax Hospital  Falls Church  VA  USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02692813"},{"@type":"EISSN","@value":"13652036"}],"prism:publicationName":[{"@value":"Alimentary Pharmacology & Therapeutics"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2012-09-08","prism:volume":"36","prism:number":"8","prism:startingPage":"772","prism:endingPage":"781"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapt.12038"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/apt.12038"}],"createdAt":"2012-09-08","modifiedAt":"2023-09-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004236077245696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Physical activity and risk of fatty liver in people with different levels of alcohol consumption: a prospective cohort study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168770660608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Editorial: twenty minutes of moderate‐to‐vigorous physical activity a day keeps the NAFLD away—authors' reply"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643747368704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dose–response relationships of accelerometer‐measured sedentary behaviour and physical activity with non‐alcoholic fatty liver disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390574876232836608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: new trends and role of ultrasonography"},{"@language":"ja","@value":"非アルコール性脂肪肝疾患/非アルコール性脂肪性肝炎の超音波診断"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/apt.12038"},{"@type":"CROSSREF","@value":"10.1136/bmjopen-2014-005824_references_DOI_PZcGjRhmjk4e8yOZ2p3KRFgTohq"},{"@type":"CROSSREF","@value":"10.1007/s10396-020-01058-y_references_DOI_PZcGjRhmjk4e8yOZ2p3KRFgTohq"},{"@type":"CROSSREF","@value":"10.1111/apt.16688_references_DOI_PZcGjRhmjk4e8yOZ2p3KRFgTohq"},{"@type":"CROSSREF","@value":"10.1111/apt.16631_references_DOI_PZcGjRhmjk4e8yOZ2p3KRFgTohq"},{"@type":"CROSSREF","@value":"10.3179/jjmu.jjmu.r.201_references_DOI_PZcGjRhmjk4e8yOZ2p3KRFgTohq"}]}