{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994278451712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0891-5849(03)00040-6"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0891-5849(03)00040-6?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0891-5849(03)00040-6?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"12684091"}},{"identifier":{"@type":"NAID","@value":"30004321316"}}],"dc:title":[{"@value":"Rosmarinic acid inhibits lung injury induced by diesel exhaust particles"}],"description":[{"notation":[{"@value":"Epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) may be involved in recent increases in lung diseases. DEP has been shown to generate reactive oxygen species. Intratracheal instillation of DEP induces lung inflammation and edema in mice. Rosmarinic acid is a naturally occurring polyphenol with antioxidative and anti-inflammatory activities. We investigated the effects of rosmarinic acid on lung injury induced by intratracheal administration of DEP (500 microg/body) in mice. Oral supplementation with administration of rosmarinic acid (2 mg/body for 3 d) inhibited DEP-induced lung injury, which was characterized by neutrophil sequestration and interstitial edema. DEP enhanced the lung expression of keratinocyte chemoattractant (KC), interleukin-1beta, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1alpha, which was inhibited by treatment with rosmarinic acid. DEP enhanced expression of iNOS mRNA and formation of nitrotyrosine and 8-OHdG in the lung, which was also inhibited by rosmarinic acid. These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1581698601087916928","@type":"Researcher","foaf:name":[{"@value":"C Sanbongi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08915849"}],"prism:publicationName":[{"@value":"Free Radical Biology and Medicine"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2003-04-15","prism:volume":"34","prism:number":"8","prism:startingPage":"1060","prism:endingPage":"1069"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0891-5849(03)00040-6?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0891-5849(03)00040-6?httpAccept=text/plain"}],"createdAt":"2003-04-07","modifiedAt":"2019-03-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Free%20Radicals","dc:title":"Free Radicals"},{"@id":"https://cir.nii.ac.jp/all?q=Administration,%20Oral","dc:title":"Administration, Oral"},{"@id":"https://cir.nii.ac.jp/all?q=Nitric%20Oxide%20Synthase%20Type%20II","dc:title":"Nitric Oxide Synthase Type II"},{"@id":"https://cir.nii.ac.jp/all?q=Bronchoalveolar%20Lavage","dc:title":"Bronchoalveolar Lavage"},{"@id":"https://cir.nii.ac.jp/all?q=Depsides","dc:title":"Depsides"},{"@id":"https://cir.nii.ac.jp/all?q=Antioxidants","dc:title":"Antioxidants"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Phenols","dc:title":"Phenols"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Chemokine%20CCL4","dc:title":"Chemokine CCL4"},{"@id":"https://cir.nii.ac.jp/all?q=Lung","dc:title":"Lung"},{"@id":"https://cir.nii.ac.jp/all?q=Rosmarinic%20Acid","dc:title":"Rosmarinic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Chemokine%20CCL2","dc:title":"Chemokine CCL2"},{"@id":"https://cir.nii.ac.jp/all?q=Vehicle%20Emissions","dc:title":"Vehicle Emissions"},{"@id":"https://cir.nii.ac.jp/all?q=Flavonoids","dc:title":"Flavonoids"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Polyphenols","dc:title":"Polyphenols"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20Injury","dc:title":"Lung Injury"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophage%20Inflammatory%20Proteins","dc:title":"Macrophage Inflammatory Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Chemical","dc:title":"Models, Chemical"},{"@id":"https://cir.nii.ac.jp/all?q=Cinnamates","dc:title":"Cinnamates"},{"@id":"https://cir.nii.ac.jp/all?q=Cytokines","dc:title":"Cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=Tyrosine","dc:title":"Tyrosine"},{"@id":"https://cir.nii.ac.jp/all?q=Chemokines","dc:title":"Chemokines"},{"@id":"https://cir.nii.ac.jp/all?q=Nitric%20Oxide%20Synthase","dc:title":"Nitric Oxide Synthase"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168858912640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of Nocturnal UV-B Irradiation on Growth, Flowering, and Phytochemical Concentration in Leaves of Greenhouse-Grown Red Perilla"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711302899072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rebamipide suppresses mite-induced asthmatic responses in NC/Nga 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