{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994350018048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0013-9351(03)00063-x"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S001393510300063X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S001393510300063X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"12865046"}}],"dc:title":[{"@value":"DNA-adduct formation in lungs, nasal mucosa, and livers of rats exposed to urban roadside air in Kawasaki City, Japan"}],"description":[{"notation":[{"@value":"The potency of ambient air for DNA-adduct formation was estimated using Wistar rats. The animals were maintained in a small-animal facility located beside a main highway intersection in Kawasaki City, Japan, for up to 60 weeks and were exposed to roadside air contaminated mainly with automobile emission (exposure group, EG) or to clean air (control group, CG). Compared to CG, the relative adduct levels (RAL) were increased significantly in EG lungs (17.1-fold (P0.05)), nasal mucosa, and livers after exposure for 4 weeks. However, there were no significant differences in RAL between EG and CG after exposure for 12 weeks, but they were elevated again in EG after exposure for 48 or 60 weeks. These results suggest that roadside air in this region can cause the generation of DNA adducts. This activity of ambient roadside air can be estimated using experimental animals, indicating that biological monitoring of DNA-adduct formation may be a powerful tool to assess the effect of ambient air on human health."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994350017922","@type":"Researcher","foaf:name":[{"@value":"Hiromi Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994350017924","@type":"Researcher","foaf:name":[{"@value":"Kazuo T. Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994350017923","@type":"Researcher","foaf:name":[{"@value":"Hideko Sone"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994350017920","@type":"Researcher","foaf:name":[{"@value":"Yuko Yamano"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994350017921","@type":"Researcher","foaf:name":[{"@value":"Jun Kagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994350018048","@type":"Researcher","foaf:name":[{"@value":"Yasunobu Aoki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00139351"}],"prism:publicationName":[{"@value":"Environmental Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2003-09","prism:volume":"93","prism:number":"1","prism:startingPage":"36","prism:endingPage":"44"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S001393510300063X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S001393510300063X?httpAccept=text/plain"}],"createdAt":"2003-06-02","modifiedAt":"2019-03-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Air%20Pollutants","dc:title":"Air Pollutants"},{"@id":"https://cir.nii.ac.jp/all?q=Urban%20Population","dc:title":"Urban Population"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Environmental%20Exposure","dc:title":"Environmental Exposure"},{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Northern","dc:title":"Blotting, Northern"},{"@id":"https://cir.nii.ac.jp/all?q=Carbon","dc:title":"Carbon"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Adducts","dc:title":"DNA Adducts"},{"@id":"https://cir.nii.ac.jp/all?q=Nasal%20Mucosa","dc:title":"Nasal Mucosa"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Cytochrome%20P-450%20CYP1A2","dc:title":"Cytochrome P-450 CYP1A2"},{"@id":"https://cir.nii.ac.jp/all?q=Administration,%20Inhalation","dc:title":"Administration, Inhalation"},{"@id":"https://cir.nii.ac.jp/all?q=Cytochrome%20P-450%20CYP1A1","dc:title":"Cytochrome P-450 CYP1A1"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Lung","dc:title":"Lung"},{"@id":"https://cir.nii.ac.jp/all?q=Vehicle%20Emissions","dc:title":"Vehicle Emissions"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001205257779584","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In Vivo Mutagenesis Caused by Diesel Exhaust in the Testis of gpt delta Transgenic Mice"},{"@value":"In vivo mutagenesis caused by diesel exhaust in the testis of gpt delta mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679397644928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"環境から暴露される化学物質の生体影響評価―変異原物質を例として―"},{"@language":"en","@value":"Estimation of biological effects caused by chemical contaminants in the environment —In vivo mutagenesis of environmental 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