{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994378909440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0165-1838(98)00174-x"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S016518389800174X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S016518389800174X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"9935268"}},{"identifier":{"@type":"NAID","@value":"30009723122"}}],"dc:title":[{"@value":"c-Kit immunoreactive interstitial cells in the human gastrointestinal tract"}],"description":[{"notation":[{"@value":"c-Kit immunopositive cells are considered to be pacemakers and/or mediators of neurotransmission in the gastrointestinal tract. They also correspond to the interstitial cells of Cajal (ICs) in mice. The normal distribution of c-Kit positive cells and their relation to ICs in the human gastrointestinal tract remain unclear. In this study we examine the distribution of c-Kit positive cells and their ultrastructure in normal human tissue. We then classified them and examined their relationship to ICs. Thirty nine samples of gut from the esophagus to the sigmoid colon from humans (ranging in age from a 16 week old fetus to a 57 year old and without motility disorders), were processed for immunohistochemistry, electronmicroscopy and immuno-electronmicroscopy. c-Kit immunopositive cells were located in the external muscle from the lower esophagus to the sigmoid colon, wherever the external muscle was composed of smooth muscle cells, and they were classified morphologically into two groups. Cells in the first group were mainly spindle-shaped bipolar cells with few branches; these cells ran parallel to nearby smooth muscle. Ultrastructurally, they possessed many intermediate filaments and caveolae. The spindle-shaped cells were present in the esophagus, stomach and small intestine. The second group of cells were located only in the colon, and were multipolar or bipolar cells with numerous branches. Cells in the second group were also rich in caveolae and/or smooth endoplasmic reticulum, but intermediate filaments were not prominent. Although both groups of c-Kit immunopositive cells corresponded to ICs, some ICs in the human gut do not appear to express c-Kit immunoreactivity."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994378909442","@type":"Researcher","foaf:name":[{"@value":"Shigeko Torihashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994378909441","@type":"Researcher","foaf:name":[{"@value":"Minoru Horisawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994378909440","@type":"Researcher","foaf:name":[{"@value":"Yoshio Watanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01651838"}],"prism:publicationName":[{"@value":"Journal of the Autonomic Nervous System"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1999-01","prism:volume":"75","prism:number":"1","prism:startingPage":"38","prism:endingPage":"50"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S016518389800174X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S016518389800174X?httpAccept=text/plain"}],"createdAt":"2002-07-25","modifiedAt":"2025-09-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Confocal","dc:title":"Microscopy, Confocal"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Infant,%20Newborn","dc:title":"Infant, Newborn"},{"@id":"https://cir.nii.ac.jp/all?q=Infant","dc:title":"Infant"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins%20c-kit","dc:title":"Proto-Oncogene Proteins c-kit"},{"@id":"https://cir.nii.ac.jp/all?q=Pregnancy","dc:title":"Pregnancy"},{"@id":"https://cir.nii.ac.jp/all?q=Child,%20Preschool","dc:title":"Child, Preschool"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Immunoelectron","dc:title":"Microscopy, Immunoelectron"},{"@id":"https://cir.nii.ac.jp/all?q=Digestive%20System","dc:title":"Digestive System"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218531989120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092534689920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interstitial cells of Cajal are diminished in critically ill patients: Autopsy cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707362952704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Newly raised <scp>anti‐c‐Kit</scp> antibody visualizes morphology of interstitial cells of Cajal in the developing gut of chicken embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894872263936","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Gastrointestinal stromal tumors and KIT‐positive mesenchymal cells in the omentum"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204213644416","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case Report of Lack of Expression of C-KIT in Gastrointestinal Stromal Tumor of the Stomach."},{"@value":"Ｃ‐ＫＩＴ陰性であったＧＩＳＴの１例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204846149248","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A CASE OF GASTROINTESTINAL STROMAL TUMOR OF THE SMALL INTESTINE WITH PERITONEAL DISSEMINATION TREATED BY STI571"},{"@value":"ＳＴＩ５７１（メシル酸イマチニブ）が奏効した腹膜播種陽性小腸ＧＩＳＴの１例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204919656320","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case of C-kit-negative Rectal Gastrointestinal Stromal Tumor with Stalk"},{"@value":"直腸壁外性に有茎性発育したＫＩＴ陰性ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ　ｓｔｒｏｍａｌ　ｔｕｍｏｒの１例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205055896576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Examination of the role of cholinergic myenteric neurons with the impairment of neural reflexes in the ileum of c-kit mutant mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205220071552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"カハールの介在細胞　　ＩＣＣの発生"},{"@language":"en","@value":"Development of ICC"},{"@language":"ja","@value":"ICCの発生"},{"@language":"ja-Kana","@value":"ICC ノ ハッセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679247977472","@type":"Article","resourceType":"学術雑誌論文(journal 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children"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176228780800","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interstitial cells of Cajal in the normal gut and in intestinal motility disorders of childhood"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450042062336","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"EXPRESSION OF THE EMBRYONIC FORM OF SMOOTH MUSCLE MYOSIN HEAVY CHAIN IN GASTROINTESTINAL STROMAL TUMORS, INTERSTITIAL CELLS OF CAJAL (ICCS) AND ICC-LIKE CELLS IN THE GASTROINTESTINAL TRACT AND 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