{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994411462016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2007.02.039"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X07003051?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X07003051?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"17321500"}}],"dc:title":[{"@value":"Tooth regeneration from newly established cell lines from a molar tooth germ epithelium"}],"description":[{"notation":[{"@value":"In order to investigate tooth development, several cell lines of the dental epithelium and ectomesenchyme have been established. However, no attempt has been reported to regenerate teeth with cell lines. Here, we have established several clonal cell lines of the dental epithelium from a p53-deficient fetal mouse. They expressed specific markers of the dental epithelium such as ameloblastin and amelogenin. A new method has been developed to bioengineer tooth germs with dental epithelial and mesenchymal cells. Reconstructed tooth germs with cell lines and fetal mesenchymal cells were implanted under kidney capsule. The germs regenerated teeth with well-calcified structures as seen in natural tooth. Germs without the cell lines developed bone. This is the first success to regenerate teeth with dental epithelial cell lines. They are useful models in vitro for investigation of mechanisms in morphogenesis and of cell lineage in differentiation, and for clinical application for tooth regeneration."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994411462019","@type":"Researcher","foaf:name":[{"@value":"Akihiko Komine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411462018","@type":"Researcher","foaf:name":[{"@value":"Kazuhisa Nakao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411462017","@type":"Researcher","foaf:name":[{"@value":"Momoko Suenaga"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411462016","@type":"Researcher","foaf:name":[{"@value":"Takashi Tsuji"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411462020","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Tomooka"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2007-04","prism:volume":"355","prism:number":"3","prism:startingPage":"758","prism:endingPage":"763"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X07003051?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X07003051?httpAccept=text/plain"}],"createdAt":"2007-02-16","modifiedAt":"2019-01-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Amelogenin","dc:title":"Amelogenin"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Engineering","dc:title":"Tissue Engineering"},{"@id":"https://cir.nii.ac.jp/all?q=Molar","dc:title":"Molar"},{"@id":"https://cir.nii.ac.jp/all?q=Epithelium","dc:title":"Epithelium"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Mutant%20Strains","dc:title":"Mice, Mutant Strains"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Germ%20Cells","dc:title":"Germ Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Dental%20Enamel%20Proteins","dc:title":"Dental Enamel Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Regeneration","dc:title":"Regeneration"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Suppressor%20Protein%20p53","dc:title":"Tumor Suppressor Protein p53"},{"@id":"https://cir.nii.ac.jp/all?q=Tooth","dc:title":"Tooth"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004239981948800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bone Formation in a Scaffold Composed of Cylindrical Hydroxyapatite and Tryptophan- or Lysine-Coated Sponge &lt;i&gt;in Vivo&lt;/i&gt;"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707535102080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Essential roles of G9a in cell proliferation and differentiation during tooth development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181953993344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Establishment of adipose-derived mesenchymal stem cell lines from a p53-knockout mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185474089984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Gadd45g</i> regulates dental epithelial cell proliferation through p38 <scp>MAPK</scp>‐mediated <i>p21</i> expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1523669554534730880","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Attempt to develop taste bud models in three-dimensional culture"},{"@language":"ja-Kana","@value":"Attempt to develop taste bud models in three dimensional culture"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2007.02.039"},{"@type":"OPENAIRE","@value":"doi_dedup___::83014bedd183ef92f030de776400a265"},{"@type":"CROSSREF","@value":"10.4236/jbise.2015.86037_references_DOI_RWQjQ24a782lS25Atu2yozCl9m0"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2012.08.094_references_DOI_RWQjQ24a782lS25Atu2yozCl9m0"},{"@type":"CROSSREF","@value":"10.1111/gtc.12067_references_DOI_RWQjQ24a782lS25Atu2yozCl9m0"},{"@type":"CROSSREF","@value":"10.1016/j.yexcr.2017.05.016_references_DOI_RWQjQ24a782lS25Atu2yozCl9m0"},{"@type":"CROSSREF","@value":"10.2108/zsj.28.623_references_DOI_RWQjQ24a782lS25Atu2yozCl9m0"}]}