{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994411538048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m610724200"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820547224?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820547224?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M610724200"}},{"identifier":{"@type":"PMID","@value":"17553795"}},{"identifier":{"@type":"NAID","@value":"80018376781"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Glyceraldehyde-3-phosphate Dehydrogenase Enhances Transcriptional Activity of Androgen Receptor in Prostate Cancer Cells"}],"description":[{"notation":[{"@value":"Androgen receptor (AR) functions as a transcriptional factor for genes involved in proliferation and differentiation of normal and cancerous prostate cells. Coactivators that bind to AR are required for maximal androgen action. Here we report that increasing the expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in a prostate cancer cell line by as little as 1.8-fold enhances transcriptional activity of AR (but not the transcriptional activity of glucocorticoid receptor or estrogen receptor alpha) in a ligand-dependent manner and results in an increased expression of prostate-specific antigen. Small interference RNA-mediated knockdown of GAPDH significantly attenuated ligand-activated AR transactivation. Immunoprecipitation analysis revealed the presence of an endogenous protein complex containing GAPDH and AR in both the cytoplasm and nucleus. Addition of a nuclear localization signal (NLS) to GAPDH (GAPDH-NLS) completely abolished the ability of GAPDH to transactivate AR. Neither wild-type GAPDH nor GAPDH-NLS enhanced transcriptional activity of mutant AR (AR Delta C-Nuc) that is a constitutively active form of AR in the nucleus, even though GAPDH-NLS formed a complex with wild-type AR or AR Delta C-Nuc. AR transactivation was enhanced by a mutant GAPDH lacking dehydrogenase activity. GAPDH enhanced the transcriptional activity of AR(T875A) activated by an antagonist such as hydroxyflutamide or cyproterone acetate. These results indicate that GAPDH functions as a coactivator with high selectivity for AR and enhances AR transactivation independent of its glycolytic activity. Further, these data suggest that formation of a GAPDH.AR complex in the cytoplasm rather than nucleus is essential for GAPDH to enhance AR transactivation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326216259072","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00529141"},{"@type":"NRID","@value":"1000000529141"},{"@type":"ORCID","@value":"0000-0003-3846-388X"},{"@type":"NRID","@value":"9000006613625"},{"@type":"NRID","@value":"9000398131151"},{"@type":"NRID","@value":"9000390873715"},{"@type":"NRID","@value":"9000257999172"},{"@type":"NRID","@value":"9000265253642"},{"@type":"NRID","@value":"9000409802441"},{"@type":"NRID","@value":"9000402800893"},{"@type":"NRID","@value":"9000399777681"},{"@type":"NRID","@value":"9000397682825"},{"@type":"NRID","@value":"9000399229133"},{"@type":"NRID","@value":"9000237727305"},{"@type":"NRID","@value":"9000391910394"},{"@type":"NRID","@value":"9000404514298"},{"@type":"NRID","@value":"9000261687337"},{"@type":"NRID","@value":"9000253337523"},{"@type":"NRID","@value":"9000257999049"},{"@type":"NRID","@value":"9000412602751"},{"@type":"NRID","@value":"9000019972461"},{"@type":"NRID","@value":"9000315141390"},{"@type":"NRID","@value":"9000406386362"},{"@type":"NRID","@value":"9000413252002"},{"@type":"NRID","@value":"9000378109080"},{"@type":"NRID","@value":"9000241686592"},{"@type":"NRID","@value":"9000298893792"},{"@type":"NRID","@value":"9000409492234"},{"@type":"NRID","@value":"9000291608261"},{"@type":"NRID","@value":"9000005477443"},{"@type":"NRID","@value":"9000368940459"},{"@type":"NRID","@value":"9000017364000"},{"@type":"NRID","@value":"9000242925094"},{"@type":"NRID","@value":"9000398253987"},{"@type":"NRID","@value":"9000412602558"},{"@type":"NRID","@value":"9000002946593"},{"@type":"NRID","@value":"9000002871931"},{"@type":"NRID","@value":"9000265253628"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/naoki_harada"}],"foaf:name":[{"@value":"Naoki Harada"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411537920","@type":"Researcher","foaf:name":[{"@value":"Ryoko Yasunaga"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411538049","@type":"Researcher","foaf:name":[{"@value":"Yasuki Higashimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411538050","@type":"Researcher","foaf:name":[{"@value":"Ryoichi Yamaji"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276162679680","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40294566"},{"@type":"NRID","@value":"1000040294566"},{"@type":"NRID","@value":"9000364657835"},{"@type":"NRID","@value":"9000007062550"},{"@type":"NRID","@value":"9000411771280"},{"@type":"NRID","@value":"9000253171442"},{"@type":"NRID","@value":"9000005181310"},{"@type":"NRID","@value":"9000391608812"},{"@type":"NRID","@value":"9000253081587"},{"@type":"NRID","@value":"9000283112707"},{"@type":"NRID","@value":"9000004731101"},{"@type":"NRID","@value":"9000016851597"},{"@type":"NRID","@value":"9000014431710"},{"@type":"NRID","@value":"9000391608193"},{"@type":"NRID","@value":"9000253170431"},{"@type":"NRID","@value":"9000254139058"},{"@type":"NRID","@value":"9000021495110"},{"@type":"NRID","@value":"9000401865436"},{"@type":"NRID","@value":"9000003374777"},{"@type":"NRID","@value":"9000254226793"},{"@type":"NRID","@value":"9000252997277"},{"@type":"NRID","@value":"9000287292972"},{"@type":"NRID","@value":"9000257923997"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054242"}],"foaf:name":[{"@value":"Katsumi Fujimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411538054","@type":"Researcher","foaf:name":[{"@value":"Joel Moss"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411538053","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Inui"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994411538052","@type":"Researcher","foaf:name":[{"@value":"Yoshihisa Nakano"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"}],"prism:publicationName":[{"@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2007-08","prism:volume":"282","prism:number":"31","prism:startingPage":"22651","prism:endingPage":"22661"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0021925820547224?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021925820547224?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M610724200"}],"createdAt":"2007-06-07","modifiedAt":"2022-01-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Transcriptional%20Activation","dc:title":"Transcriptional Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription,%20Genetic","dc:title":"Transcription, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Localization%20Signals","dc:title":"Nuclear Localization Signals"},{"@id":"https://cir.nii.ac.jp/all?q=Glyceraldehyde-3-Phosphate%20Dehydrogenases","dc:title":"Glyceraldehyde-3-Phosphate Dehydrogenases"},{"@id":"https://cir.nii.ac.jp/all?q=Prostatic%20Neoplasms","dc:title":"Prostatic Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Glucocorticoid","dc:title":"Receptors, Glucocorticoid"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Androgen","dc:title":"Receptors, Androgen"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=COS%20Cells","dc:title":"COS Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Chlorocebus%20aethiops","dc:title":"Chlorocebus aethiops"},{"@id":"https://cir.nii.ac.jp/all?q=Androgens","dc:title":"Androgens"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782480070400","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19592147"},{"@type":"JGN","@value":"JP19592147"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592147/"}],"notation":[{"@language":"ja","@value":"心筋および神経分化におけるbHLH型転写因子DEC2の機能解析"},{"@language":"en","@value":"Functional analyses of the bHLH transcription factor DEC2 in cardiac and neural differentiations."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564288893348096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling 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Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617864003456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ribosome-Engineered\n            <i>Lacticaseibacillus rhamnosus</i>\n            Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183932712832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Coordinated Action of Hypoxia-inducible Factor-1α and β-Catenin in Androgen Receptor Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184125771392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protein arginine methyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185506295808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Androgen deprivation causes truncation of the <scp>C</scp>‐terminal region of androgen receptor in human prostate cancer <scp>LNCaP</scp> cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189705338496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118737273984","@type":"Article","resourceType":"学術雑誌論文(journal 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the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel–Lindau tumor suppressor protein-independent regulatory mechanisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656932237952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661250100736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704792150272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206324006912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Resveratrol Down-Regulates the Androgen Receptor at the Post-Translational Level in Prostate Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679175957376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Ｍｏｏｎｌｉｇｈｔｉｎｇタンパク質として見直されるＧＡＰＤＨの機能　　アンドロゲン受容体の転写活性におけるコアクチベーターとしての役割"},{"@language":"ja-Kana","@value":"Moonlighting タンパクシツ ト シテ ミナオサレル GAPDH ノ キノウ アンドロゲン ジュヨウタイ ノ テンシャ カッセイ ニ オケル コアクチベーター ト シテノ ヤクワリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680678556032","@type":"Article","resourceType":"学術雑誌論文(journal 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