{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994436645376.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/mnfr.201800178"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201800178"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201800178"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mnfr.201800178"}}],"dc:title":[{"@value":"Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Scope</jats:title><jats:p>GTPs (green tea polyphenols) exert anti‐CRC (colorectal cancer) activity. The intestinal microbiota and intestinal colonization by bacteria of oral origin has been implicated in colorectal carcinogenesis. GT modulates the composition of mouse gut microbiota harmonious with anticancer activity. Therefore, the effect of green tea liquid (GTL) consumption on the gut and oral microbiome is investigated in healthy volunteers (<jats:italic>n</jats:italic> = 12).</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>16S sequencing and phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analysis of both fecal and saliva samples (collected before intervention, after 2 weeks of GTL (400 mL per day) and after a washout period of one week) in healthy volunteers show changes in microbial diversity and core microbiota and difference in clear classification (partial least squares‐discriminant analysis [PLS‐DA]). An irreversible, increased FIR:BAC (<jats:italic>Firmicutes</jats:italic> to <jats:italic>Bacteroidetes</jats:italic> ratio), elevated SCFA producing genera, and reduction of bacterial LPS synthesis in feces are discovered in response to GTL. GTL alters the salivary microbiota and reduces the functional pathways abundance relevance to carcinogenesis. Similar bacterial networks in fecal and salivary microbiota datasets comprising putative oral bacteria are found and GTL reduces the fecal levels of <jats:italic>Fusobacterium</jats:italic>. Interestingly, both <jats:italic>Lachnospiraceae</jats:italic> and B/E (<jats:italic>Bifidobacterium</jats:italic> to <jats:italic>Enterobacteriacea</jats:italic> ratio—markers of colonization resistance [CR]) are negatively associated with the presence of oral‐like bacterial networks in the feces.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results suggest that GTL consumption causes both oral and gut microbiome alterations.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994436645385","@type":"Researcher","foaf:name":[{"@value":"Xiaojie Yuan"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645384","@type":"Researcher","foaf:name":[{"@value":"Yong Long"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645377","@type":"Researcher","foaf:name":[{"@value":"Zhaohua Ji"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645381","@type":"Researcher","foaf:name":[{"@value":"Jie Gao"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645382","@type":"Researcher","foaf:name":[{"@value":"Ting Fu"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645378","@type":"Researcher","foaf:name":[{"@value":"Min Yan"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645386","@type":"Researcher","foaf:name":[{"@value":"Lei Zhang"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645379","@type":"Researcher","foaf:name":[{"@value":"Haixia Su"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645251","@type":"Researcher","foaf:name":[{"@value":"Weilu Zhang"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645249","@type":"Researcher","foaf:name":[{"@value":"Xiaohui Wen"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645252","@type":"Researcher","foaf:name":[{"@value":"Zhongshu Pu"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645250","@type":"Researcher","foaf:name":[{"@value":"Hui Chen"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645376","@type":"Researcher","foaf:name":[{"@value":"Yufei Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645383","@type":"Researcher","foaf:name":[{"@value":"Xu Gu"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645380","@type":"Researcher","foaf:name":[{"@value":"Binyuan Yan"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645253","@type":"Researcher","foaf:name":[{"@value":"Kanakaraju Kaliannan"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Lipid Medicine and Technology Department of Medicine, 149 13th Street Massachusetts General Hospital and Harvard Medical School  Boston MA 02129 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994436645248","@type":"Researcher","foaf:name":[{"@value":"Zhongjun Shao"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi'an Shannxi 710032 China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16134125"},{"@type":"EISSN","@value":"16134133"}],"prism:publicationName":[{"@value":"Molecular Nutrition & Food Research"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2018-06","prism:volume":"62","prism:number":"12","prism:startingPage":"e1800178"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201800178"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201800178"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mnfr.201800178"}],"createdAt":"2018-05-11","modifiedAt":"2023-08-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142863130624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390566222336","@type":"Article","resourceType":"学術雑誌論文(journal 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