{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994451446656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jvi.00239-07"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/JVI.00239-07"}}],"dc:title":[{"@value":"Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>The study of the evolution and specificities of neutralizing antibodies during the course of human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of possible targets for vaccine design. In this study, we assessed the autologous and heterologous neutralization responses of 14 HIV-1 subtype C-infected individuals, using envelope clones obtained within the first 2 months postinfection. Our data show that potent but relatively strain-specific neutralizing antibodies develop within 3 to 12 months of HIV-1 infection. The magnitude of this response was associated with shorter V1-to-V5 envelope lengths and fewer glycosylation sites, particularly in the V1-V2 region. Anti-MPER antibodies were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing antibodies. However, neither anti-MPER nor anti-CD4i antibody specificity conferred neutralization breadth. These data provide insights into the kinetics, potency, breadth, and epitope specificity of neutralizing antibody responses in acute HIV-1 subtype C infection.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848661763610117","@type":"Researcher","foaf:name":[{"@value":"E. S. Gray"}],"jpcoar:affiliationName":[{"@value":"AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446664","@type":"Researcher","foaf:name":[{"@value":"P. L. Moore"}],"jpcoar:affiliationName":[{"@value":"AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446663","@type":"Researcher","foaf:name":[{"@value":"I. A. Choge"}],"jpcoar:affiliationName":[{"@value":"AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446658","@type":"Researcher","foaf:name":[{"@value":"J. M. Decker"}],"jpcoar:affiliationName":[{"@value":"University of Alabama at Birmingham, Birmingham, Alabama 35294"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446667","@type":"Researcher","foaf:name":[{"@value":"F. Bibollet-Ruche"}],"jpcoar:affiliationName":[{"@value":"University of Alabama at Birmingham, Birmingham, Alabama 35294"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446662","@type":"Researcher","foaf:name":[{"@value":"H. Li"}],"jpcoar:affiliationName":[{"@value":"University of Alabama at Birmingham, Birmingham, Alabama 35294"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446661","@type":"Researcher","foaf:name":[{"@value":"N. Leseka"}],"jpcoar:affiliationName":[{"@value":"AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446668","@type":"Researcher","foaf:name":[{"@value":"F. Treurnicht"}],"jpcoar:affiliationName":[{"@value":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446656","@type":"Researcher","foaf:name":[{"@value":"K. Mlisana"}],"jpcoar:affiliationName":[{"@value":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446660","@type":"Researcher","foaf:name":[{"@value":"G. M. Shaw"}],"jpcoar:affiliationName":[{"@value":"University of Alabama at Birmingham, Birmingham, Alabama 35294"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446665","@type":"Researcher","foaf:name":[{"@value":"S. S. Abdool Karim"}],"jpcoar:affiliationName":[{"@value":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446657","@type":"Researcher","foaf:name":[{"@value":"C. Williamson"}],"jpcoar:affiliationName":[{"@value":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994451446666","@type":"Researcher","foaf:name":[{"@value":"L. Morris"}],"jpcoar:affiliationName":[{"@value":"AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0022538X"},{"@type":"EISSN","@value":"10985514"}],"prism:publicationName":[{"@value":"Journal of Virology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2007-06-15","prism:volume":"81","prism:number":"12","prism:startingPage":"6187","prism:endingPage":"6196"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/JVI.00239-07"}],"createdAt":"2007-04-05","modifiedAt":"2022-03-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567184886587776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Generation of a replication-competent simian–human immunodeficiency virus, the neutralization sensitivity of which can be enhanced in the presence of a small-molecule CD4 mimic"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661763610240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/jvi.00239-07"},{"@type":"CROSSREF","@value":"10.1099/vir.0.055590-0_references_DOI_TCIhSLA2OZbFK3ZtlzpTO4QE5y5"},{"@type":"CROSSREF","@value":"10.1186/s12977-017-0369-y_references_DOI_TCIhSLA2OZbFK3ZtlzpTO4QE5y5"}]}