{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994455658496.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.hyp.0000136394.08900.ed"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000136394.08900.ed"}},{"identifier":{"@type":"PMID","@value":"15238569"}},{"identifier":{"@type":"NAID","@value":"30022678110"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Safety Evaluation of Clinical Gene Therapy Using Hepatocyte Growth Factor to Treat Peripheral Arterial Disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Therapeutic angiogenesis using angiogenic growth factors is expected to be a new treatment for patients with critical limb ischemia (CLI). Because hepatocyte growth factor (HGF) has potent angiogenic activity, we investigated the safety and efficiency of HGF plasmid DNA in patients with CLI as a prospective open-labeled clinical trial. Intramuscular injection of naked HGF plasmid DNA was performed in ischemic limbs of 6 CLI patients with arteriosclerosis obliterans (n=3) or Buerger disease (n=3) graded as Fontaine III or IV. The primary end points were safety and improvement of ischemic symptoms at 12 weeks after transfection. Severe complications and adverse effects caused by gene transfer were not detected in any patients. Of particular importance, no apparent edema was observed in any patient throughout the trial. In addition, serum HGF concentration was not changed throughout the therapy period in all patients. In contrast, a reduction of pain scale of more than 1 cm in visual analog pain scale was observed in 5 of 6 patients. Increase in ankle pressure index more than 0.1 was observed in 5 of 5 patients. The long diameter of 8 of 11 ischemic ulcers in 4 patients was reduced >25%. Intramuscular injection of naked HGF plasmid is safe, feasible, and can achieve successful improvement of ischemic limbs. Although the present data are conducted to demonstrate the safety as phase I/early phase IIa, the initial clinical outcome with HGF gene transfer seems to indicate usefulness as sole therapy for CLI.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994455658498","@type":"Researcher","foaf:name":[{"@value":"Ryuichi Morishita"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658625","@type":"Researcher","foaf:name":[{"@value":"Motokuni Aoki"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658501","@type":"Researcher","foaf:name":[{"@value":"Naotaka Hashiya"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658500","@type":"Researcher","foaf:name":[{"@value":"Hirofumi Makino"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658502","@type":"Researcher","foaf:name":[{"@value":"Keita Yamasaki"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658624","@type":"Researcher","foaf:name":[{"@value":"Junya Azuma"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658503","@type":"Researcher","foaf:name":[{"@value":"Yoshiki Sawa"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658497","@type":"Researcher","foaf:name":[{"@value":"Hikaru Matsuda"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276181354496","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10177537"},{"@type":"NRID","@value":"1000010177537"},{"@type":"CINII_AUTHOR_ID","@value":"DA17905724"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA17905724#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA17905724"},{"@type":"NRID","@value":"9000003882855"},{"@type":"NRID","@value":"9000364319780"},{"@type":"NRID","@value":"9000020374008"},{"@type":"NRID","@value":"9000369338934"},{"@type":"NRID","@value":"9000011126714"},{"@type":"NRID","@value":"9000004063210"},{"@type":"NRID","@value":"9000004095204"},{"@type":"NRID","@value":"9000347361194"},{"@type":"NRID","@value":"9000411762006"},{"@type":"NRID","@value":"9000240138911"},{"@type":"NRID","@value":"9000262342427"},{"@type":"NRID","@value":"9000002584929"},{"@type":"NRID","@value":"9000014581849"},{"@type":"NRID","@value":"9000391585035"},{"@type":"NRID","@value":"9000014167211"},{"@type":"NRID","@value":"9000321621789"},{"@type":"NRID","@value":"9000004079597"},{"@type":"NRID","@value":"9000021246569"},{"@type":"NRID","@value":"9000253181099"},{"@type":"NRID","@value":"9000366494816"},{"@type":"NRID","@value":"9000399593192"},{"@type":"NRID","@value":"9000004324346"},{"@type":"NRID","@value":"9000242545161"},{"@type":"NRID","@value":"9000254451049"},{"@type":"NRID","@value":"9000257807688"},{"@type":"NRID","@value":"9000397963746"},{"@type":"NRID","@value":"9000001964807"},{"@type":"NRID","@value":"9000258735228"},{"@type":"NRID","@value":"9000350651846"},{"@type":"NRID","@value":"9000022114392"},{"@type":"NRID","@value":"9000005761590"},{"@type":"NRID","@value":"9000369339087"},{"@type":"NRID","@value":"9000369338949"},{"@type":"NRID","@value":"9000369338940"},{"@type":"NRID","@value":"9000332223611"},{"@type":"NRID","@value":"9000256487054"},{"@type":"NRID","@value":"9000024822740"},{"@type":"NRID","@value":"9000398019902"},{"@type":"NRID","@value":"9000254057444"},{"@type":"NRID","@value":"9000406221846"},{"@type":"NRID","@value":"9000410910238"},{"@type":"NRID","@value":"9000018355382"},{"@type":"NRID","@value":"9000018205800"},{"@type":"NRID","@value":"9000018344274"},{"@type":"NRID","@value":"9000381066210"},{"@type":"NRID","@value":"9000001796186"},{"@type":"NRID","@value":"9000256866597"},{"@type":"NRID","@value":"9000283343524"},{"@type":"NRID","@value":"9000283522300"},{"@type":"NRID","@value":"9000398260936"},{"@type":"NRID","@value":"9000318583840"},{"@type":"NRID","@value":"9000414805919"},{"@type":"NRID","@value":"9000021279158"},{"@type":"NRID","@value":"9000406038793"},{"@type":"NRID","@value":"9000356649305"},{"@type":"NRID","@value":"9000001817822"},{"@type":"NRID","@value":"9000254419382"},{"@type":"NRID","@value":"9000365496172"},{"@type":"NRID","@value":"9000314400622"},{"@type":"NRID","@value":"9000356649287"},{"@type":"NRID","@value":"9000391588299"},{"@type":"NRID","@value":"9000335557724"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/YK-MWK0108"}],"foaf:name":[{"@value":"Yasufumi Kaneda"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994455658496","@type":"Researcher","foaf:name":[{"@value":"Toshio Ogihara"}],"jpcoar:affiliationName":[{"@value":"From the Department of Geriatric Medicine (R.M., M.A., N.H., H.M., K.Y., J.A., T.O.), Division of Clinical Gene Therapy (R.M.), Department of Surgery (Y.S., H.M.), and Division of Gene Therapy Science (Y.K.), Graduate School of Medicine, Osaka University, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2004-08","prism:volume":"44","prism:number":"2","prism:startingPage":"203","prism:endingPage":"209"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000136394.08900.ed"}],"createdAt":"2004-07-07","modifiedAt":"2024-05-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Peripheral%20Vascular%20Diseases","dc:title":"Peripheral Vascular Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Leg","dc:title":"Leg"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatocyte%20Growth%20Factor","dc:title":"Hepatocyte Growth Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Leg%20Ulcer","dc:title":"Leg Ulcer"},{"@id":"https://cir.nii.ac.jp/all?q=Thromboangiitis%20Obliterans","dc:title":"Thromboangiitis Obliterans"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Therapy","dc:title":"Genetic Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Injections,%20Intramuscular","dc:title":"Injections, Intramuscular"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Regional%20Blood%20Flow","dc:title":"Regional Blood Flow"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Angiography","dc:title":"Magnetic Resonance Angiography"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Pain%20Measurement","dc:title":"Pain Measurement"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256792850176","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15591404"},{"@type":"JGN","@value":"JP15591404"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15591404/"}],"notation":[{"@language":"ja","@value":"蛋白早期発現を利用した肝虚血再潅流傷害・低温保存傷害の制御法の開発"},{"@language":"en","@value":"Suppression of hepatic ischemia/reperfusion injury by early expression of protective protein"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050018296277334016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"下肢閉塞性動脈硬化症治療の最先端　重症虚血肢に対するバイパス手術の最先端　困難例に対する挑戦"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217576509824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hepatocyte growth factor and Met in drug discovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706195326720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707387108352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia/Reperfusion in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711767168384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617427204480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Title: Gene transfer by pyro-drive jet injector is a novel therapeutic approach for muscle diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905630617984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis of Diethylamino End‐Modified Poly(Ethylene Glycol) With Imine Spacer to Form Mono‐Ion Complexes With <scp>pDNA</scp>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579814639740032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tunable Gene Expression in Skeletal Muscles by the Molecular Weight of PEG Chain Length of Plasmid DNA Mono-ion Complexes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340712693504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis of <i>N</i>-oxide Poly(1-vinylimidazole) for pDNA delivery systems <i>in vivo</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380158982528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diffusive delivery of plasmid DNA using zwitterionic carboxyalkyl poly(1-vinylimidazole) into skeletal muscle <i>in vivo</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643150683648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hepatocyte growth factor twenty years on: Much more than a growth factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656148351872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hypocellularity and insufficient expression of angiogenic factors in implanted autologous bone marrow in patients with chronic critical limb ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664406481024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HGF–Met Pathway in Regeneration and Drug Discovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593802457344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guanidinopropyl end‐modified poly(ethylene glycol) to form highly compact plasmid <scp>DNA</scp> mono‐ion complexes by thermal treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204147664640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology, life sciences and clinical medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204432733952","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204642161536","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tissue regeneration by recruitment of stem cells to injured tissues"},{"@value":"体内細胞動員による再生治療"},{"@language":"ja-Kana","@value":"タイナイ サイボウ ドウイン ニ ヨル サイセイ チリョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205102958848","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Serum Levels of S-Glutathionylated Proteins as a Risk-Marker for Arteriosclerosis Obliterans"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205103066880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Body Position on Skin Perfusion Pressure in Patients With Severe Peripheral Arterial Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679443876224","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"2光子イメージングで探る大脳皮質の機能構築と局所回路"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679602066048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of Cell-Specific Targeting Systems for Drugs and Genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679609488384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pretreatment with Epidermal Growth Factor Enhances Naked Plasmid DNA Transfer onto Gastric Serosal Surface in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679619260032","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"DDS技術を活用した体内再生誘導治療"},{"@language":"en","@value":"Neuronal Regeneration by Using Endogenous Stem Cells and DDS Technology"},{"@language":"ja-Kana","@value":"DDS ギジュツ オ カツヨウ シタ タイナイ サイセイ ユウドウ チリョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679705233024","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Optimal Culture Conditions for Constructing Durable Biografts for Repairing the Impaired Heart-Dynamic Cell Culture with Pre-seeding-"},{"@value":"Optimal Culture Conditions for Constructing Durable Biografts for Repairing the Impaired Heart —Dynamic Cell Culture with Pre-seeding—"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680000606464","@type":"Article","resourceType":"other","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of gerontology in the era of a super-aged society"},{"@language":"ja","@value":"超高齢社会と老年学"},{"@value":"会長講演 超高齢社会と老年学"},{"@language":"ja-Kana","@value":"カイチョウ コウエン チョウコウレイ シャカイ ト ロウネンガク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680079358848","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680081318528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Autologous Bone-Marrow Cell Transplantation on Ischemic Ulcer in Patients With Buerger's Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282763010692992","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"遺伝子を用いた虚血性疾患治療の現状と将来(3. 血管新生療法の現状と将来, <特集>第69回日本循環器学会学術集会)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285300169387520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Therapeutic Angiogenesis Using HGF Plasmid"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564237986852608","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"末梢性血管疾患に対する遺伝子治療臨床研究(5. 心血管病のトランスレーショナルリサーチ, <特集>第69回日本循環器学会学術集会)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845712965178752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"心不全研究の進歩(循環器学2004年の進歩)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390854717521973760","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"1) Gene Therapy as Future Medicine: from Regenerative Medicine to DNA Vaccine"},{"@language":"ja","@value":"1）次世代医薬品としての遺伝子治療：血管再生遺伝子治療から DNAワクチンまで"}]},{"@id":"https://cir.nii.ac.jp/crid/1520290882218872576","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"凍結ヒト心筋細胞移植--凍結処理が移植細胞の増殖能,抗原性に与える影響"},{"@language":"ja-Kana","@value":"トウケツ ヒト シンキン サイボウ イショク トウケツ ショリ ガ イショク サイボウ ノ ゾウショクノウ コウゲンセイ ニ アタエル エイキョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1520573330066573312","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Stimulation of hepatocyte growth factor production by heparin-derived oligosaccharides"},{"@language":"ja-Kana","@value":"Stimulation of hepatocyte growth factor production by heparin derived oligosaccharides"}]},{"@id":"https://cir.nii.ac.jp/crid/1520853833434410624","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"血管病変への再生医療(3)末梢血管病変への再生医療"},{"@language":"ja-Kana","@value":"ケッカン ビョウヘン エ ノ サイセイ イリョウ 3 マッショウ ケッカン ビョウヘン エ ノ サイセイ イリョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225540634112","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hepatocyte growth factor promotes remodeling of murine liver fibrosis, accelerating recruitment of bone marrow-derived cells into the liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175386625920","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"次世代血管新生治療を目指した遺伝子機能スクリーニング"},{"@language":"en","@value":"Development of functional gene screening for therapeutic angiogenesis in next generation"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175524868992","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"循環制御による分子治療"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651035600512","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"末梢動脈疾患に対する自家末梢血幹細胞移植の現状"},{"@language":"en","@value":"Autologous Peripheral Blood Mononuclear Cell Transplantation for Peripheral Arterial Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075322094848","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"浅大腿動脈の慢性完全閉塞病変に対して足背動脈アプローチで経皮的血管形成術に成功した1例"},{"@language":"en","@value":"Percutaneous Transluminal Angioplasty via Dorsalis Pedis Artery for Chronic Total Occlusion of Superficial Femoral Artery : A Case Report"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500604560896","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"血管新生遺伝子治療の臨床応用の現況"},{"@language":"en","@value":"Recent Progress of Therapeutic Angiogenesis and Gene Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449980819712","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"TREAT-HGF : HGF遺伝子を用いた末梢血管疾患に対する遺伝子治療の臨床研究"},{"@language":"en","@value":"Therapeutic Angiogenesis Using HGF (Hepatocyte Growth Factor) Gene to Treat Peripheral Arterial Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874915908352","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"脈管研究の新しい潮流-ゲノム時代を迎えて"},{"@language":"en","@value":"The Nishimaru Memorial Lecture : Recent Progress in Cardiovascular Research"}]},{"@id":"https://cir.nii.ac.jp/crid/2051151842055755904","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular design of polymer-based carriers for plasmid DNA delivery in vitro and in vivo"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/01.hyp.0000136394.08900.ed"},{"@type":"CIA","@value":"30022678110"},{"@type":"KAKEN","@value":"PRODUCT-18576648"},{"@type":"KAKEN","@value":"PRODUCT-18576653"},{"@type":"OPENAIRE","@value":"doi_dedup___::9b865accb92c16c0fd4ea2b375892c26"},{"@type":"CROSSREF","@value":"10.1093/jb/mvv027_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.5761/atcs.oa.10.01650_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.3400/avd.ra.20-00035_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.2169/naika.110.407_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1007/s00380-015-0677-x_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1186/1479-5876-9-55_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.5551/jat.13.77_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1016/j.omtm.2018.07.009_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.3143/geriatrics.51.16_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1016/j.gene.2021.145664_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1002/pat.70025_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1253/circj.71.100_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.2183/pjab.86.588_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1253/circj.71.1187_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1253/circj.70.1190_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.2745/dds.27.246_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1253/jjcsc.13.2_233_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1246/cl.220242_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1093/chemle/upae044_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1039/d4bm00510d_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1111/j.1440-1746.2010.06549.x_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1007/s00380-011-0125-5_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.3390/biomedicines2040275_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1248/bpb.35.903_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.3902/jnns.19.3_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1246/cl.190696_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1253/jjcsc.13.2_265_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1253/jjcsc.13.1_103_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1002/pat.5530_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-12-0562_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.2745/dds.32.46_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"},{"@type":"CROSSREF","@value":"10.1248/bpb.28.195_references_DOI_DrYjbzB1BE4eOFW5hoa1Lb7HKVf"}]}