{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994468096000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1515/ntrev-2011-0005"}},{"identifier":{"@type":"URI","@value":"https://www.degruyter.com/view/journals/ntrev/1/2/article-p111.xml"}},{"identifier":{"@type":"URI","@value":"https://www.degruyter.com/downloadpdf/journals/ntrev/1/2/article-p111.xml"}}],"dc:title":[{"@value":"Can nanotechnology potentiate photodynamic therapy?"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Photodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specificity. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on <jats:italic>in vivo</jats:italic> studies and nanotoxicology, we attempt to answer the title question, “can nanotechnology potentiate PDT?”</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994468096006","@type":"Researcher","foaf:name":[{"@value":"Ying-Ying Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096005","@type":"Researcher","foaf:name":[{"@value":"Sulbha K. Sharma"}],"jpcoar:affiliationName":[{"@value":"1Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St., Boston, MA 02114, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096128","@type":"Researcher","foaf:name":[{"@value":"Tianhong Dai"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096002","@type":"Researcher","foaf:name":[{"@value":"Hoon Chung"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096001","@type":"Researcher","foaf:name":[{"@value":"Anastasia Yaroslavsky"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096003","@type":"Researcher","foaf:name":[{"@value":"Maria Garcia-Diaz"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096004","@type":"Researcher","foaf:name":[{"@value":"Julie Chang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096129","@type":"Researcher","foaf:name":[{"@value":"Long Y. Chiang"}],"jpcoar:affiliationName":[{"@value":"7Department of Chemistry, University of Massachusetts, Lowell, MA, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994468096000","@type":"Researcher","foaf:name":[{"@value":"Michael R. Hamblin"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"21919097"},{"@type":"PISSN","@value":"21919089"}],"prism:publicationName":[{"@value":"Nanotechnology Reviews"}],"dc:publisher":[{"@value":"Walter de Gruyter GmbH"}],"prism:publicationDate":"2012-03-01","prism:volume":"1","prism:number":"2","prism:startingPage":"111","prism:endingPage":"146"},"reviewed":"false","url":[{"@id":"https://www.degruyter.com/view/journals/ntrev/1/2/article-p111.xml"},{"@id":"https://www.degruyter.com/downloadpdf/journals/ntrev/1/2/article-p111.xml"}],"createdAt":"2012-10-01","modifiedAt":"2021-02-27","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360565166588422784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Generation of Singlet Oxygen by Photoexcited Au<sub>25</sub>(SR)<sub>18</sub> Clusters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181968777088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis of protoporphyrin–lipids and biological evaluation of micelles and liposomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657218096768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of ligand species and cluster size of biomolecule-protected Au nanoclusters on eff iciency of singlet-oxygen generation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288106979200","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Photosensitizers in antibacterial photodynamic therapy: an overview"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1515/ntrev-2011-0005"},{"@type":"CROSSREF","@value":"10.1016/j.bmc.2014.07.003_references_DOI_NFjL8f0G91YGl0Uv8sT73AecEsj"},{"@type":"CROSSREF","@value":"10.1021/cm500260z_references_DOI_NFjL8f0G91YGl0Uv8sT73AecEsj"},{"@type":"CROSSREF","@value":"10.5978/islsm.27_18-ra-01_references_DOI_NFjL8f0G91YGl0Uv8sT73AecEsj"},{"@type":"CROSSREF","@value":"10.1016/j.jlumin.2016.08.059_references_DOI_NFjL8f0G91YGl0Uv8sT73AecEsj"}]}