{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994480794496.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000089175"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/89175"}}],"dc:title":[{"@value":"Interaction Effect in Bladder Cancer between N-Acetyltransferase 2 Genotype and Alcohol Drinking"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Cigarette smoking, aromatic amines and ionizing radiation are known carcinogens of bladder cancer. NAT2 genotype might play a role in bladder cancer carcinogenesis. This hospital-based, case-control study was conducted in Kaohsiung, Taiwan, which neighbors the high incidence region of bladder cancer in the black-foot disease area. A total of 103 cases with diagnosed bladder cancer were collected. For each case, 1 control was selected from the same hospital. A structured questionnaire was applied for all cases and controls. DNA was extracted from peripheral blood cell. The ASO-PCR/RFLP technique was used to determine the NAT2 genotype. For bladder cancer, the significantly excessive risks were observed in regular drinkers (OR = 2.74, 95% CI = 1.28–5.87) and residents of the black-foot disease endemic area (OR = 7.53, 95% CI = 2.16–26.33), and interaction of regular drinking and slow type of NAT2 (OR = 18.04, 95% CI = 2.28–142.80). We suggested that NAT2 genotype might play a role of effect modifier in bladder cancer carcinogenesis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994480794499","@type":"Researcher","foaf:name":[{"@value":"Chih-Ming Lu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994480794496","@type":"Researcher","foaf:name":[{"@value":"Meng-Chu Chung"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994480794498","@type":"Researcher","foaf:name":[{"@value":"Chung-Hsiung Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994480794497","@type":"Researcher","foaf:name":[{"@value":"Ying-Chin Ko"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00421138"},{"@type":"EISSN","@value":"14230399"}],"prism:publicationName":[{"@value":"Urologia Internationalis"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2005","prism:volume":"75","prism:number":"4","prism:startingPage":"360","prism:endingPage":"364"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/89175"}],"createdAt":"2005-12-05","modifiedAt":"2025-04-24","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002214394547200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modifying Effect of <i>N</i>‐Acetyltransferase 2 Genotype on the Association Between Systemic Lupus Erythematosus and Consumption of Alcohol and Caffeine‐Rich Beverages"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000089175"},{"@type":"CROSSREF","@value":"10.1002/acr.22282_references_DOI_76EonDylLx3GQh7pP1Fi3CWOnNB"}]}