{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994495359872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbaexp.2004.09.007"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0167478104001952?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0167478104001952?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"15507321"}}],"dc:title":[{"@value":"A point mutation in a silencer module reduces the promoter activity for the human mercaptopyruvate sulfurtransferase"}],"description":[{"notation":[{"@value":"A promoter region of human mercaptopyruvate sulfurtransferase (MST) [EC 2.8.1.2] is G+C-rich and TATA-less, showing features of a house-keeping gene. In the core promoter, a GC box (-284:GGGGCGTGGC:-275) and an initiator (-219:TTATATG:-225) are found. A cap site hunting analysis for human liver cDNA revealed four possible transcriptional start sites, nucleotides -223, -159, -35 and -25. Point mutagenesis and deletion studies suggest that a module of the silencer element is -394:GCTG:-391. A replacement of -391G to C lost the silencer function; on the other hand, a replacement of -394G to T or C, -393C to T or -392T to G markedly reduced the promoter activity."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994495359877","@type":"Researcher","foaf:name":[{"@value":"Noriyuki Nagahara"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994495359876","@type":"Researcher","foaf:name":[{"@value":"V.G. Sreeja"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994495359875","@type":"Researcher","foaf:name":[{"@value":"Qing Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994495359873","@type":"Researcher","foaf:name":[{"@value":"Takako Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994495359874","@type":"Researcher","foaf:name":[{"@value":"Terumasa Tsuchiya"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994495359872","@type":"Researcher","foaf:name":[{"@value":"Yoshiaki Fujii-Kuriyama"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01674781"}],"prism:publicationName":[{"@value":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2004-11","prism:volume":"1680","prism:number":"3","prism:startingPage":"176","prism:endingPage":"184"},"reviewed":"false","url":[{"@id":"https://api.elsevier.com/content/article/PII:S0167478104001952?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0167478104001952?httpAccept=text/plain"}],"createdAt":"2004-10-05","modifiedAt":"2021-06-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Binding%20Sites","dc:title":"Binding Sites"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Complementary","dc:title":"DNA, Complementary"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Enzymologic","dc:title":"Gene Expression Regulation, Enzymologic"},{"@id":"https://cir.nii.ac.jp/all?q=GC%20Rich%20Sequence","dc:title":"GC Rich Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Enhancer%20Elements,%20Genetic","dc:title":"Enhancer Elements, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Homology,%20Nucleic%20Acid","dc:title":"Sequence Homology, Nucleic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Sulfurtransferases","dc:title":"Sulfurtransferases"},{"@id":"https://cir.nii.ac.jp/all?q=Silencer%20Elements,%20Transcriptional","dc:title":"Silencer Elements, Transcriptional"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Point%20Mutation","dc:title":"Point Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Cloning,%20Molecular","dc:title":"Cloning, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Initiation%20Site","dc:title":"Transcription Initiation Site"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Deletion","dc:title":"Sequence Deletion"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360283692453767424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of Mercaptopyruvate Sulfurtransferase Activity\n                    <i>Via</i>\n                    Intrasubunit and Intersubunit Redox-Sensing Switches"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181885941632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Redox Regulation of Mammalian 3-Mercaptopyruvate Sulfurtransferase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641785204224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643075266816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Multiple role of 3‐mercaptopyruvate sulfurtransferase: antioxidative function, H<sub>2</sub>S and polysulfide production and possible SO<sub>x</sub> production"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.bbaexp.2004.09.007"},{"@type":"OPENAIRE","@value":"doi_dedup___::9fd8e926d7be6d5e65dff2c56d24c628"},{"@type":"CROSSREF","@value":"10.1016/bs.mie.2014.11.017_references_DOI_7r7ObyjHlF06bLowY6FsiUHWx5i"},{"@type":"CROSSREF","@value":"10.1038/srep01986_references_DOI_7r7ObyjHlF06bLowY6FsiUHWx5i"},{"@type":"CROSSREF","@value":"10.1111/bph.14100_references_DOI_7r7ObyjHlF06bLowY6FsiUHWx5i"},{"@type":"CROSSREF","@value":"10.1089/ars.2012.5031_references_DOI_7r7ObyjHlF06bLowY6FsiUHWx5i"}]}