{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994504214656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0272-6386(04)00936-9"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/plain"}},{"identifier":{"@type":"DOI","@value":"10.1053/j.ajkd.2004.06.008"}},{"identifier":{"@type":"URI","@value":"http://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"http://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"15384017"}},{"identifier":{"@type":"NAID","@value":"30015141706"}}],"dc:title":[{"@value":"Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS)"}],"description":[{"notation":[{"@value":"Experimental and some clinical data suggest that metabolic acidosis contributes to poor nutritional status, a strong predictor for mortality in hemodialysis patients. However, recent cross-sectional studies indicate that severe predialysis metabolic acidosis is associated with a greater normalized protein catabolic rate (nPCR) and greater serum albumin levels. Given this controversy, we analyzed data from the Dialysis Outcomes and Practice Pattern Study (DOPPS) for associations between predialysis serum bicarbonate and albumin concentrations, nPCR, and patient risk for mortality and hospitalization.Data from more than 7,000 representative and randomly selected hemodialysis DOPPS patients from France, Germany, Italy, Japan, Spain, the United Kingdom, and the United States were analyzed. Serum bicarbonate (total CO2 ) levels predialysis were corrected to the midweek interdialytic interval.The midweek predialysis serum bicarbonate level averaged 21.9 mEq/L (mmol/L) and correlated inversely with nPCR, serum albumin, and serum phosphorus values. Before and after adjusting for 15 comorbidities, nutrition, and equilibrated Kt/V, a U-curve best represented the association between predialysis serum bicarbonate level and risk for mortality or hospitalization. Patients with midweek predialysis serum bicarbonate levels of 20.1 to 21.0 mEq/L (mmol/L) faced the lowest risk for mortality, whereas those with bicarbonate levels of 21.1 to 22.0 mEq/L faced the lowest risk for hospitalization. Both high (27 mEq/L) and low (or =17 mEq/L) serum bicarbonate levels were associated with increased risk for mortality and hospitalization.Moderate predialysis acidosis seems to be associated with better nutritional status and lower relative risk for mortality or hospitalization than is observed in patients with normal ranges of midweek predialysis serum bicarbonate concentration (approximately 24 mEq/L) or severe acidosis (16 mEq/L)."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994504214658","@type":"Researcher","foaf:name":[{"@value":"Jürgen Bommer"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214663","@type":"Researcher","foaf:name":[{"@value":"Francesco Locatelli"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214657","@type":"Researcher","foaf:name":[{"@value":"Sudtida Satayathum"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214664","@type":"Researcher","foaf:name":[{"@value":"Marcia L. Keen"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214661","@type":"Researcher","foaf:name":[{"@value":"David A. Goodkin"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214659","@type":"Researcher","foaf:name":[{"@value":"Akira Saito"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214656","@type":"Researcher","foaf:name":[{"@value":"Takashi Akiba"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214662","@type":"Researcher","foaf:name":[{"@value":"Friedrich K. Port"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994504214660","@type":"Researcher","foaf:name":[{"@value":"Eric W. Young"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02726386"}],"prism:publicationName":[{"@value":"American Journal of Kidney Diseases"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2004-10","prism:volume":"44","prism:number":"4","prism:startingPage":"661","prism:endingPage":"671"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/plain"},{"@id":"http://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/xml"},{"@id":"http://api.elsevier.com/content/article/PII:S0272638604009369?httpAccept=text/plain"}],"createdAt":"2008-03-18","modifiedAt":"2018-12-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Hospitalization","dc:title":"Hospitalization"},{"@id":"https://cir.nii.ac.jp/all?q=Risk","dc:title":"Risk"},{"@id":"https://cir.nii.ac.jp/all?q=Bicarbonates","dc:title":"Bicarbonates"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Renal%20Dialysis","dc:title":"Renal Dialysis"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Failure,%20Chronic","dc:title":"Kidney Failure, Chronic"},{"@id":"https://cir.nii.ac.jp/all?q=Nutritional%20Status","dc:title":"Nutritional Status"},{"@id":"https://cir.nii.ac.jp/all?q=Acidosis","dc:title":"Acidosis"},{"@id":"https://cir.nii.ac.jp/all?q=Serum%20Albumin","dc:title":"Serum Albumin"},{"@id":"https://cir.nii.ac.jp/all?q=Proportional%20Hazards%20Models","dc:title":"Proportional Hazards Models"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848661332540672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of Serum Bicarbonate with Bone Fractures in Hemodialysis Patients: The Mineral and Bone Disorder Outcomes Study for Japanese CKD Stage 5D Patients (MBD-5D)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661712389248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Switching hemodialysis patients from sevelamer hydrochloride to bixalomer: a single-center, non-randomized analysis of efficacy and effects on gastrointestinal symptoms and metabolic acidosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204957627648","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"慢性透析療法の現況"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679655237248","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Management of pH of dialysis fluid using Carbostar directly effects the acid-base status in maintenance hemodialysis patients"},{"@language":"ja","@value":"カーボスター透析液の調整と慢性維持透析患者の酸塩基平衡"},{"@language":"ja-Kana","@value":"カーボスター トウセキエキ ノ チョウセイ ト マンセイ イジ トウセキ カンジャ ノ サンエンキ ヘイコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679656068224","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"本誌46(7)：651～659，2013『カーボスター透析液の調整と慢性維持透析患者の酸塩基平衡』（正井基之，ほか）の論文について"},{"@value":"Letter to Editor 本誌46(7):651~659,2013『カーボスター透析液の調整と慢性維持透析患者の酸塩基平衡』(正井基之,ほか)の論文について"},{"@language":"ja-Kana","@value":"Letter to Editor ホンシ 46(7):651~659,2013 『 カーボスター トウセキエキ ノ チョウセイ ト マンセイ イジ トウセキ カンジャ ノ サンエンキ ヘイコウ 』(セイイキユキ,ホカ)ノ ロンブン ニ ツイテ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679656553984","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prospective observational study of sevelamer hydrochloride and lanthanum carbonate-Effect of sevelamer hydrochloride on the acid-base equilibrium of patients on hemodialysis with citric acid dialysate"},{"@language":"ja","@value":"塩酸セベラマーと炭酸ランタンの酸塩基平衡に対する効果の前向き研究"},{"@language":"ja-Kana","@value":"エンサン セベラマー ト タンサン ランタン ノ サンエンキ ヘイコウ ニ タイスル コウカ ノ マエムキ ケンキュウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679657467776","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The effects of sevelamer hydrochloride on metabolic acidosis in hemodialysis patients with citrate dialysate"},{"@language":"ja","@value":"塩酸セベラマー内服量が血液透析患者の酸塩基平衡に及ぼす影響―クエン酸透析液使用でも，代謝性アシドーシスを悪化させるか？―"},{"@language":"ja-Kana","@value":"エンサン セベラマー ナイフクリョウ ガ ケツエキ トウセキ カンジャ ノ サンエンキ ヘイコウ ニ オヨボス エイキョウ クエンサン トウセキエキ シヨウ デモ タイシャセイ アシドーシス オ アッカ サセル カ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679849673216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Persistent Metabolic Acidosis in a Hemodialyzed Patient with Short Bowel Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845713084755072","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"サルコペニア・フレイルを合併した透析期CKDの食事療法"},{"@value":"委員会報告 サルコペニア・フレイルを合併した透析期CKDの食事療法"},{"@language":"ja-Kana","@value":"イインカイ ホウコク サルコペニア ・ フレイル オ ガッペイ シタ トウセキキ CKD ノ ショクジ リョウホウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0272-6386(04)00936-9"},{"@type":"CROSSREF","@value":"10.1053/j.ajkd.2004.06.008"},{"@type":"CIA","@value":"30015141706"},{"@type":"OPENAIRE","@value":"doi_dedup___::dc8788d3642b8bd6b64a7dde6d6ab37d"},{"@type":"CROSSREF","@value":"10.4009/jsdt.46.1033_references_DOI_RvlhgTt1b1iqaTL7R6D9jrPvIZ4"},{"@type":"CROSSREF","@value":"10.4009/jsdt.43.373_references_DOI_6ib76viNg7Jl39jkXYwMBHLVOfx"},{"@type":"CROSSREF","@value":"10.1159/000365089_references_DOI_RvlhgTt1b1iqaTL7R6D9jrPvIZ4"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.52.0029_references_DOI_6ib76viNg7Jl39jkXYwMBHLVOfx"},{"@type":"CROSSREF","@value":"10.4009/jsdt.46.651_references_DOI_6ib76viNg7Jl39jkXYwMBHLVOfx"},{"@type":"CROSSREF","@value":"10.1186/1471-2369-14-222_references_DOI_6ib76viNg7Jl39jkXYwMBHLVOfx"},{"@type":"CROSSREF","@value":"10.4009/jsdt.43.763_references_DOI_6ib76viNg7Jl39jkXYwMBHLVOfx"},{"@type":"CROSSREF","@value":"10.4009/jsdt.52.397_references_DOI_6ib76viNg7Jl39jkXYwMBHLVOfx"}]}