{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994524280832.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/adfm.201603084"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadfm.201603084"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.201603084"}}],"dc:title":[{"@value":"Nitrogen‐Doped Carbon Quantum Dot Stabilized Magnetic Iron Oxide Nanoprobe for Fluorescence, Magnetic Resonance, and Computed Tomography Triple‐Modal In Vivo Bioimaging"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Multimodal imaging, which combines complementary information of two or more imaging modalities, offers huge advantages. In this paper, the synthesis, characterization, and application of superparamagnetic nitrogen‐doped carbon‐iron oxide hybrid quantum dots (C‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> QDs) is reported for triple‐modal bioimaging through fluorescence/magnetic resonance/computed tomography (FL/MR/CT). Especially, C‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> QDs are synthesized by using poly (γ‐glutamic acid) as a precursor and stabilizer via a green and facile one‐pot hydrothermal approach. The as‐prepared C‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> QDs exhibit excellent water dispersibility, wavelength‐tunable FL property with high quantum yield of about 21.6%, good photostability, strong superparamagnetic property as well as favorable biocompatibility. Meanwhile, these C‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> QDs also show a transverse relaxivity value (<jats:italic>r</jats:italic>\n<jats:sub>2</jats:sub>) of 154.10 m<jats:sc>m</jats:sc>\n<jats:sup>−1</jats:sup> s<jats:sup>−1</jats:sup> for T<jats:sub>2</jats:sub>‐weighted MR imaging mode and an observable X‐ray attenuation effect for CT imaging mode. Moreover, the in vivo bioimaging of tumor‐bearing nude mice by combining FL, MR, and CT images further demonstrates that the as‐prepared C‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> QDs can be readily and efficiently used in FL/MR/CT triple‐modal tumor imaging. Hence, the new and facile one‐pot synthesis strategy for preparing multifunctional C‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> QDs nanoprobes provides a convenient way for achieving an effective and versatile agent for tumorous bioimaging/or diagnostics.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994524280835","@type":"Researcher","foaf:name":[{"@value":"Xiaoli Liu"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280834","@type":"Researcher","foaf:name":[{"@value":"Hui Jiang"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280707","@type":"Researcher","foaf:name":[{"@value":"Jing Ye"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280833","@type":"Researcher","foaf:name":[{"@value":"Chunqiu Zhao"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280705","@type":"Researcher","foaf:name":[{"@value":"Shengping Gao"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280704","@type":"Researcher","foaf:name":[{"@value":"Changyu Wu"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280706","@type":"Researcher","foaf:name":[{"@value":"Changhui Li"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280708","@type":"Researcher","foaf:name":[{"@value":"Jincheng Li"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994524280832","@type":"Researcher","foaf:name":[{"@value":"Xuemei Wang"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Bioelectronics (Chien‐Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1616301X"},{"@type":"EISSN","@value":"16163028"}],"prism:publicationName":[{"@value":"Advanced Functional Materials"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-08-31","prism:volume":"26","prism:number":"47","prism:startingPage":"8694","prism:endingPage":"8706"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadfm.201603084"},{"@id":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.201603084"}],"createdAt":"2016-08-31","modifiedAt":"2025-10-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360849939809153152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near‐Infrared Fluorescence In Vivo Tumor Imaging"},{"@language":"en","@value":"Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near-Infrared Fluorescence In Vivo Tumor Imaging."}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593817864448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent advances in waste-recycled nanomaterials for biomedical applications: Waste-to-wealth"}]},{"@id":"https://cir.nii.ac.jp/crid/1520010380619610112","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rapid Synthesis of C-dots@PGV Nanocomposites Powders for Development of Latent Fingermarks"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/adfm.201603084"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20170182_references_DOI_Tzg6r9zHpFxt9rD3FnvxKhXvKew"},{"@type":"CROSSREF","@value":"10.1002/smll.201901930_references_DOI_Tzg6r9zHpFxt9rD3FnvxKhXvKew"},{"@type":"CROSSREF","@value":"10.1515/ntrev-2021-0099_references_DOI_Tzg6r9zHpFxt9rD3FnvxKhXvKew"}]}