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This Ser\n            <jats:sup>118</jats:sup>\n            is phosphorylated by mitogen-activated protein kinase (MAPK) in vitro and in cells treated with epidermal growth factor (EGF) and insulin-like growth factor (IGF) in vivo. Overexpression of MAPK kinase (MAPKK) or of the guanine nucleotide binding protein Ras, both of which activate MAPK, enhanced estrogen-induced and antiestrogen (tamoxifen)-induced transcriptional activity of wild-type ER, but not that of a mutant ER with an alanine in place of Ser\n            <jats:sup>118</jats:sup>\n            . Thus, the activity of the amino-terminal AF-1 of the ER is modulated by the phosphorylation of Ser\n            <jats:sup>118</jats:sup>\n            through the Ras-MAPK cascade of the growth factor signaling pathways.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420577199220013312","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60204468"},{"@type":"NRID","@value":"1000060204468"},{"@type":"NRID","@value":"9000364274316"},{"@type":"NRID","@value":"9000020771030"},{"@type":"NRID","@value":"9000304303021"},{"@type":"NRID","@value":"9000017152333"},{"@type":"NRID","@value":"9000018384233"},{"@type":"NRID","@value":"9000403839875"},{"@type":"NRID","@value":"9000241449581"},{"@type":"NRID","@value":"9000253150589"},{"@type":"NRID","@value":"9000010001904"},{"@type":"NRID","@value":"9000007595430"},{"@type":"NRID","@value":"9000021145847"},{"@type":"NRID","@value":"9000010563946"},{"@type":"NRID","@value":"9000008798079"},{"@type":"NRID","@value":"9000241636173"},{"@type":"NRID","@value":"9000017561842"},{"@type":"NRID","@value":"9000256507376"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0000540"}],"foaf:name":[{"@value":"Shigeaki Kato"}],"jpcoar:affiliationName":[{"@value":"S. 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