{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994581819136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1097/wnr.0b013e3283405bad"}},{"identifier":{"@type":"URI","@value":"http://journals.lww.com/00001756-201012080-00007"}},{"identifier":{"@type":"PMID","@value":"20890230"}}],"dc:title":[{"@value":"Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats"}],"description":[{"notation":[{"@value":"Menthol is known as an agonist for cold-sensitive transient receptor potential channels (TRPM8) and also as a direct modulator of GABA channels. We examined the effects of menthol on respiratory rhythm generation in the brainstem-spinal cord preparations isolated from newborn rats. Menthol decreased respiratory rhythm dose-dependently (0.1-1 mM). Effects of menthol were reversed by the GABAA antagonist, bicuculline. Menthol caused pronounced reduction in the driving potential of pre-inspiratory but not inspiratory neurons. Expression of the TRPM8 channel protein was not detected in the respiratory related region of the rostral ventrolateral medulla by immunohistochemistry. The results suggest that the potent inhibitory action of menthol on burst generation of pre-inspiratory neurons is because of direct activation of tonic GABA channels by menthol."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994581819267","@type":"Researcher","foaf:name":[{"@value":"Mariho Tani"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994581819265","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Onimaru"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994581819266","@type":"Researcher","foaf:name":[{"@value":"Keiko Ikeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994581819136","@type":"Researcher","foaf:name":[{"@value":"Kiyoshi Kawakami"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994581819264","@type":"Researcher","foaf:name":[{"@value":"Ikuo Homma"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09594965"}],"prism:publicationName":[{"@value":"NeuroReport"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2010-12-08","prism:volume":"21","prism:number":"17","prism:startingPage":"1095","prism:endingPage":"1099"},"reviewed":"false","url":[{"@id":"http://journals.lww.com/00001756-201012080-00007"}],"createdAt":"2010-10-01","modifiedAt":"2021-04-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Medulla%20Oblongata","dc:title":"Medulla Oblongata"},{"@id":"https://cir.nii.ac.jp/all?q=Periodicity","dc:title":"Periodicity"},{"@id":"https://cir.nii.ac.jp/all?q=TRPM%20Cation%20Channels","dc:title":"TRPM Cation Channels"},{"@id":"https://cir.nii.ac.jp/all?q=Neural%20Inhibition","dc:title":"Neural Inhibition"},{"@id":"https://cir.nii.ac.jp/all?q=Respiratory%20Center","dc:title":"Respiratory Center"},{"@id":"https://cir.nii.ac.jp/all?q=Synaptic%20Transmission","dc:title":"Synaptic Transmission"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=GABA%20Antagonists","dc:title":"GABA Antagonists"},{"@id":"https://cir.nii.ac.jp/all?q=Menthol","dc:title":"Menthol"},{"@id":"https://cir.nii.ac.jp/all?q=Animals,%20Newborn","dc:title":"Animals, Newborn"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20GABA","dc:title":"Receptors, GABA"},{"@id":"https://cir.nii.ac.jp/all?q=Biological%20Clocks","dc:title":"Biological Clocks"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=gamma-Aminobutyric%20Acid","dc:title":"gamma-Aminobutyric Acid"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004236333002624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Long-lasting facilitation of respiratory rhythm by treatment with TRPA1 agonist, cinnamaldehyde"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707325286400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181191208192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656167991552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of eugenol on respiratory burst generation in newborn rat brainstem-spinal cord preparations"}]},{"@id":"https://cir.nii.ac.jp/crid/1390582308085288832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of linalool on respiratory neuron activity in the brainstem-spinal cord preparation from newborn rats"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1097/wnr.0b013e3283405bad"},{"@type":"OPENAIRE","@value":"doi_dedup___::d1debd5ca31812b6881d4f7ec70cd22a"},{"@type":"CROSSREF","@value":"10.1152/jn.00282.2015_references_DOI_TtdDU8K8oDaVnJws7SMu718oSb3"},{"@type":"CROSSREF","@value":"10.1016/j.lfs.2013.01.012_references_DOI_TtdDU8K8oDaVnJws7SMu718oSb3"},{"@type":"CROSSREF","@value":"10.1007/s00424-016-1912-8_references_DOI_TtdDU8K8oDaVnJws7SMu718oSb3"},{"@type":"CROSSREF","@value":"10.1007/s00424-017-2074-z_references_DOI_TtdDU8K8oDaVnJws7SMu718oSb3"},{"@type":"CROSSREF","@value":"10.2220/biomedres.45.151_references_DOI_TtdDU8K8oDaVnJws7SMu718oSb3"}]}