{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994586583552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/anie.201600924"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201600924"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201600924"}}],"dc:title":[{"@value":"Highly Stable Double‐Stranded DNA Containing Sequential Silver(I)‐Mediated 7‐Deazaadenine/Thymine Watson–Crick Base Pairs"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The oligonucleotide d(TX)<jats:sub>9</jats:sub>, which consists of an octadecamer sequence with alternating non‐canonical 7‐deazaadenine (X) and canonical thymine (T) as the nucleobases, was synthesized and shown to hybridize into double‐stranded DNA through the formation of hydrogen‐bonded Watson–Crick base pairs. dsDNA with metal‐mediated base pairs was then obtained by selectively replacing W‐C hydrogen bonds by coordination bonds to central silver(I) ions. The oligonucleotide <jats:bold>I</jats:bold> adopts a duplex structure in the absence of Ag<jats:sup>+</jats:sup> ions, and its stability is significantly enhanced in the presence of Ag<jats:sup>+</jats:sup> ions while its double‐helix structure is retained. Temperature‐dependent UV spectroscopy, circular dichroism spectroscopy, and ESI mass spectrometry were used to confirm the selective formation of the silver(I)‐mediated base pairs. This strategy could become useful for preparing stable metallo‐DNA‐based nanostructures.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861294227730816","@type":"Researcher","foaf:name":[{"@value":"Noelia Santamaría‐Díaz"}],"jpcoar:affiliationName":[{"@value":"Facultad de Ciencias Departamento Química Inorgánica Universidad de Granada  Avd. Fuentenueva s/n 18071 Granada Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861294227730817","@type":"Researcher","foaf:name":[{"@value":"José M. Méndez‐Arriaga"}],"jpcoar:affiliationName":[{"@value":"Facultad de Ciencias Departamento Química Inorgánica Universidad de Granada  Avd. Fuentenueva s/n 18071 Granada Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994586583553","@type":"Researcher","foaf:name":[{"@value":"Juan M. Salas"}],"jpcoar:affiliationName":[{"@value":"Facultad de Ciencias Departamento Química Inorgánica Universidad de Granada  Avd. Fuentenueva s/n 18071 Granada Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994586583425","@type":"Researcher","foaf:name":[{"@value":"Miguel A. Galindo"}],"jpcoar:affiliationName":[{"@value":"Facultad de Ciencias Departamento Química Inorgánica Universidad de Granada  Avd. Fuentenueva s/n 18071 Granada Spain"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14337851"},{"@type":"EISSN","@value":"15213773"}],"prism:publicationName":[{"@value":"Angewandte Chemie International Edition"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-03-23","prism:volume":"55","prism:number":"21","prism:startingPage":"6170","prism:endingPage":"6174"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201600924"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201600924"}],"createdAt":"2016-03-23","modifiedAt":"2023-09-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360005514549904000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Silver(I)‐Ion‐Mediated Cytosine‐Containing Base Pairs: Metal Ion Specificity for Duplex Stabilization and Susceptibility toward DNA Polymerases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189446525312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Effects of Magnesium Ions on the Enzymatic Synthesis of Ligand-Bearing Artificial DNA by Template-Independent Polymerase"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942141186048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Artificial DNA base pairing mediated by diverse metal ions"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/anie.201600924"},{"@type":"CROSSREF","@value":"10.1002/cbic.201900450_references_DOI_RFdZ6o0YAcQsaH6kCN5r3gmCz5V"},{"@type":"CROSSREF","@value":"10.1246/cl.160985_references_DOI_RFdZ6o0YAcQsaH6kCN5r3gmCz5V"},{"@type":"CROSSREF","@value":"10.3390/ijms17060906_references_DOI_RFdZ6o0YAcQsaH6kCN5r3gmCz5V"}]}