{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994590217216.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/2396987319832140"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1177/2396987319832140"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1177/2396987319832140"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/esj/article/4/1/6/8275858"}}],"dc:title":[{"@value":"European Stroke Organisation (ESO) – European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical Thrombectomy in Acute Ischaemic StrokeEndorsed by Stroke Alliance for Europe (SAFE)"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Background</jats:title>\n                    <jats:p>Mechanical thrombectomy (MT) has become the cornerstone of acute ischaemic stroke management in patients with large vessel occlusion (LVO). The aim of this guideline document is to assist physicians in their clinical decisions with regard to MT.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>These Guidelines were developed based on the standard operating procedure of the European Stroke Organisation and followed the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. An interdisciplinary working group identified 15 relevant questions, performed systematic reviews and meta-analyses of the literature, assessed the quality of the available evidence, and wrote evidence based recommendations. Expert opinion was provided if not enough evidence was available to provide recommendations based on the GRADE approach.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>We found high quality evidence to recommend MT plus best medical management (BMM, including intravenous thrombolysis whenever indicated) to improve functional outcome in patients with LVO-related acute ischaemic stroke within 6 hours after symptom onset. We found moderate quality of evidence to recommend MT plus BMM in the 6-24h time window in patients meeting the eligibility criteria of published randomized trials. These guidelines further detail aspects of prehospital management, patient selection based on clinical and imaging characteristics, and treatment modalities.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>MT is the standard of care in patients with LVO-related acute stroke. Appropriate patient selection and timely reperfusion are crucial. Further randomized trials are needed to inform clinical decision making with regard to the mothership and drip-and-ship approaches, anesthaesia modalities during MT, and to determine whether MT is beneficial in patients with low stroke severity or large infarct volume.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994590217224","@type":"Researcher","foaf:name":[{"@value":"Guillaume Turc"}],"jpcoar:affiliationName":[{"@value":"Neurology Department, Sainte-Anne Hospital, Paris, France 1"},{"@value":"Université Paris Descartes, Paris, France 2"},{"@value":"DHU NeuroVasc, Paris, France 3"},{"@value":"INSERM U1266, Paris, France 4"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217216","@type":"Researcher","foaf:name":[{"@value":"Pervinder Bhogal"}],"jpcoar:affiliationName":[{"@value":"The Royal London Hospital, London, UK 5"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217225","@type":"Researcher","foaf:name":[{"@value":"Urs Fischer"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Switzerland 6"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217218","@type":"Researcher","foaf:name":[{"@value":"Pooja Khatri"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA 7"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217221","@type":"Researcher","foaf:name":[{"@value":"Kyriakos Lobotesis"}],"jpcoar:affiliationName":[{"@value":"Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK 8"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217217","@type":"Researcher","foaf:name":[{"@value":"Mikaël Mazighi"}],"jpcoar:affiliationName":[{"@value":"DHU NeuroVasc, Paris, France 3"},{"@value":"INSERM U1148, Sorbonne Paris Cité Université Paris Diderot, Paris, France 9"},{"@value":"Department of Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France 10"},{"@value":"Stroke Unit Lariboisière Hospital, Paris, France 11"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217344","@type":"Researcher","foaf:name":[{"@value":"Peter D. Schellinger"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology and Neurogeriatry, Johannes Wesling Medical Center Minden, University hospitals of the Ruhr-University of Bochum, Germany 12"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217223","@type":"Researcher","foaf:name":[{"@value":"Danilo Toni"}],"jpcoar:affiliationName":[{"@value":"Hospital Policlinico Umberto I, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy 13"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217220","@type":"Researcher","foaf:name":[{"@value":"Joost de Vries"}],"jpcoar:affiliationName":[{"@value":"Department of Neurosurgery, Radboudumc, Nijmegen, The Netherlands 14"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217219","@type":"Researcher","foaf:name":[{"@value":"Philip White"}],"jpcoar:affiliationName":[{"@value":"Institute of Neuroscience (Stroke Research Group), Newcastle, University, Newcastle Upon Tyne, UK 15"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994590217222","@type":"Researcher","foaf:name":[{"@value":"Jens Fiehler"}],"jpcoar:affiliationName":[{"@value":"Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany 16"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"23969873"},{"@type":"EISSN","@value":"23969881"}],"prism:publicationName":[{"@value":"European Stroke Journal"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2019-03-01","prism:volume":"4","prism:number":"1","prism:startingPage":"6","prism:endingPage":"12"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights","https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1177/2396987319832140"},{"@id":"https://journals.sagepub.com/doi/full-xml/10.1177/2396987319832140"},{"@id":"https://academic.oup.com/esj/article/4/1/6/8275858"}],"createdAt":"2019-02-26","modifiedAt":"2026-01-21","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050576347193730944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endovascular Treatment of Tandem Atherosclerotic Cervical Internal Carotid Artery Occlusion in the Setting of Acute Ischemic Stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282423615872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Numerical simulation of non-linear loading–unloading hysteresis behavior of blood clots"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340514707200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Allogeneic Stem Cell Therapy for Acute Ischemic Stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519736341248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1390004951538196224","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nationwide questionnaire survey on neuroimaging strategy for acute ischemic stroke in Japan"},{"@language":"ja","@value":"急性期脳梗塞における画像診断の現状─全国アンケート調査─"}]},{"@id":"https://cir.nii.ac.jp/crid/1390579675966002688","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endovascular Therapy for Acute Stroke: New Evidence and Indications"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1177/2396987319832140"},{"@type":"CROSSREF","@value":"10.1016/j.bbe.2022.10.002_references_DOI_GHZSAyeIB5Klo734ZLzbImddySS"},{"@type":"CROSSREF","@value":"10.1177/15385744221130865_references_DOI_GHZSAyeIB5Klo734ZLzbImddySS"},{"@type":"CROSSREF","@value":"10.1001/jama.2020.23522_references_DOI_GHZSAyeIB5Klo734ZLzbImddySS"},{"@type":"CROSSREF","@value":"10.1001/jamaneurol.2023.5200_references_DOI_GHZSAyeIB5Klo734ZLzbImddySS"},{"@type":"CROSSREF","@value":"10.5797/jnet.ra.2023-0047_references_DOI_GHZSAyeIB5Klo734ZLzbImddySS"},{"@type":"CROSSREF","@value":"10.3995/jstroke.10781_references_DOI_GHZSAyeIB5Klo734ZLzbImddySS"}]}