{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994671663744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000084256"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/84256"}},{"identifier":{"@type":"PMID","@value":"15746556"}}],"dc:title":[{"@value":"Increasing Prevalence of Japanese Cedar Pollinosis: A Meta-Regression Analysis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><i>Background:</i> Japanese cedar pollinosis, caused by the pollen of the Japanese cedar tree <i>(Cryptomeria japonica)</i>, is the commonest seasonal allergic disease in Japan. A number of epidemiological surveys have been reported on Japanese cedar pollinosis, but it has never been assessed systematically or quantitatively. To confirm the increasing prevalence of Japanese cedar pollinosis and related factors, we conducted a meta-regression analysis on population-based surveys in Japan. <i>Methods:</i> We searched for data from population-based surveys in which serological methods were used to test all participants. Weighted regression of logit-transformed prevalence and sensitization rates were used to evaluate the effects of the year of survey, age, and degree of urbanization. We also analyzed the relationship between prevalence and sensitization rate. <i>Results:</i> Thirty-eight reports with 27 subgroups for prevalence and 134 subgroups for sensitization rate were selected from the literature published in the years between 1986 and 2000. The Japanese cedar pollen sensitization rate was found to be significantly correlated with the year of survey, age, and degree of urbanization (adjusted R<sup>2</sup> = 0.55). The coefficient for the correlation between the prevalence and the sensitization rate revealed a statistically significant correlation (Pearson’s r = 0.70, p < 0.001). <i>Conclusions:</i> The prevalence of Japanese cedar pollinosis among adolescents was predicted to be 28.7% in metropolitan areas and 24.5% in the general population in urban areas in the year 2004, derived from the estimated sensitization rate and the relationship between sensitization rate and prevalence. The prevalence of Japanese cedar pollinosis increased 2.6-fold between 1980 and 2000, and the prevalence differed considerably according to age and degree of urbanization.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994671663746","@type":"Researcher","foaf:name":[{"@value":"Yoshihiro Kaneko"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994671663744","@type":"Researcher","foaf:name":[{"@value":"Yutaka Motohashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994671663747","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994671663745","@type":"Researcher","foaf:name":[{"@value":"Tomohiko Endo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994671663748","@type":"Researcher","foaf:name":[{"@value":"Akira Eboshida"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10182438"},{"@type":"EISSN","@value":"14230097"}],"prism:publicationName":[{"@value":"International Archives of Allergy and Immunology"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2005","prism:volume":"136","prism:number":"4","prism:startingPage":"365","prism:endingPage":"371"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/84256"}],"createdAt":"2005-03-03","modifiedAt":"2025-04-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Cryptomeria","dc:title":"Cryptomeria"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Hypersensitivity","dc:title":"Hypersensitivity"},{"@id":"https://cir.nii.ac.jp/all?q=Prevalence","dc:title":"Prevalence"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Pollen","dc:title":"Pollen"},{"@id":"https://cir.nii.ac.jp/all?q=Regression%20Analysis","dc:title":"Regression Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050011251822022400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women : baseline data from the Kyushu Okinawa Maternal and Child Health Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810927719552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232291464704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural Basis for the Specific Recognition of the Major Antigenic Peptide from the Japanese Cedar Pollen Allergen Cry j 1 by HLA-DP5"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390571733120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707209765888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Long-Term Efficacy and Dose-Finding Trial of Japanese Cedar Pollen Sublingual Immunotherapy Tablet"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710462339840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intranasal exposure to monoclonal antibody Fab fragments to Japanese cedar pollen Cry j1 suppresses Japanese cedar pollen‐induced allergic rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165934060544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Present state of Japanese cedar pollinosis: The national affliction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181915784832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Phase I/II study of oral immunotherapy with Cry j1–galactomannan conjugate for Japanese cedar pollinosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656890074368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of Japanese cedar–specific sublingual immunotherapy on allergen-specific TH2 cell counts in 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