{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994762976384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/all.12671"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fall.12671"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.12671"}}],"dc:title":[{"@value":"Ara h 2 and Ara 6 are the best predictors of severe peanut allergy: a double‐blind placebo‐controlled study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Component‐resolved diagnostics offers a modern tool in peanut allergy, but studies applying consistently double‐blind placebo‐controlled challenges are lacking. We aimed to optimize diagnostics for moderate‐to‐severe peanut allergy in a birch‐endemic region and to create an oral‐peanut challenge with its allergen activity characterized.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed double‐blind placebo‐controlled peanut challenges for a referred sample of 6‐ to 18‐year‐olds with peanut sensitization or a high suspicion of peanut allergy, including anaphylaxis. We measured specific IgE (<jats:styled-content style=\"fixed-case\">sIgE</jats:styled-content>) to Ara h 1, 2, 3, 6, 8, and 9. Testing of allergen activity of the challenge products was by IgE microarray inhibition.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 102 patients, 69 were challenge positive: 25 (36%) had severe, 36 (52%) moderate, and 8 (12%) mild symptoms; 38 (37%) received adrenalin. <jats:styled-content style=\"fixed-case\">SI</jats:styled-content>gE to Ara h 6 <jats:styled-content style=\"fixed-case\">AUC</jats:styled-content> 0.98 (95%<jats:styled-content style=\"fixed-case\">CI</jats:styled-content>, 0.96–1.00) was the best marker of moderate‐to‐severe allergy. When <jats:styled-content style=\"fixed-case\">sIgE</jats:styled-content> to Ara h 2 and Ara h 6 was measured together, all (100%) severe reactions at low doses were successfully diagnosable. <jats:styled-content style=\"fixed-case\">SI</jats:styled-content>gE to Ara h 8 had no diagnostic value, <jats:styled-content style=\"fixed-case\">AUC</jats:styled-content> 0.42 (95%<jats:styled-content style=\"fixed-case\">CI</jats:styled-content>, 0.30–0.52). Both nonroasted and roasted peanut inhibited 100% of IgE binding to Ara h 1, 2, 3, and 6. Nonroasted peanut inhibited 87% of IgE binding to Ara h 8, roasted inhibited 30%. The products lacked Ara h 9 activity.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Co‐sensitization to Ara h 2 and Ara h 6 was associated with severe reactions distinguishing severe allergy from mild symptoms. <jats:styled-content style=\"fixed-case\">SI</jats:styled-content>gE to Ara h 8 added no diagnostic value. Component‐resolved diagnostics reduce the need for oral challenges in peanut allergy.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994762976388","@type":"Researcher","foaf:name":[{"@value":"A. K. Kukkonen"}],"jpcoar:affiliationName":[{"@value":"The Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994762976384","@type":"Researcher","foaf:name":[{"@value":"A. S. Pelkonen"}],"jpcoar:affiliationName":[{"@value":"The Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016868714801536","@type":"Researcher","foaf:name":[{"@value":"S. Mäkinen‐Kiljunen"}],"jpcoar:affiliationName":[{"@value":"The Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994762976385","@type":"Researcher","foaf:name":[{"@value":"H. Voutilainen"}],"jpcoar:affiliationName":[{"@value":"The Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994762976387","@type":"Researcher","foaf:name":[{"@value":"M. J. Mäkelä"}],"jpcoar:affiliationName":[{"@value":"The Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01054538"},{"@type":"EISSN","@value":"13989995"}],"prism:publicationName":[{"@value":"Allergy"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-07","prism:volume":"70","prism:number":"10","prism:startingPage":"1239","prism:endingPage":"1245"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fall.12671"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.12671"}],"createdAt":"2015-06-19","modifiedAt":"2023-10-03","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234880366208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oral food challenge using different target doses and time intervals between doses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236407379072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reactions of Buckwheat-Hypersensitive Patients during Oral Food Challenge Are Rare, but Often Anaphylactic"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906071089792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204474150016","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"第7章 食物経口負荷試験 (OFC)"},{"@language":"en","@value":"Commentary on Japanese Pediatric Guideline for Food Allergy 2016 Chapter 7 Oral Food Challenge Test"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204631439616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Recent advances in component resolved diagnosis in food allergy"},{"@language":"en","@value":"Recent advances in component resolved diagnosis in food allergy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390565134835797504","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Understanding buckwheat allergies for the management of allergic reactions in humans and animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1390568456337723776","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Allergen: Tree nuts and seeds"},{"@language":"ja","@value":"アレルゲン：ナッツ類・種子類"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/all.12671"},{"@type":"CROSSREF","@value":"10.1159/000456008_references_DOI_IzUSmKQIUZPY8dV6IvOCdhjrXK4"},{"@type":"CROSSREF","@value":"10.3388/jspaci.34.612_references_DOI_IzUSmKQIUZPY8dV6IvOCdhjrXK4"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2016.07.002_references_DOI_IzUSmKQIUZPY8dV6IvOCdhjrXK4"},{"@type":"CROSSREF","@value":"10.1270/jsbbs.19051_references_DOI_IzUSmKQIUZPY8dV6IvOCdhjrXK4"},{"@type":"CROSSREF","@value":"10.1016/j.waojou.2024.101001_references_DOI_IzUSmKQIUZPY8dV6IvOCdhjrXK4"},{"@type":"CROSSREF","@value":"10.3388/jspaci.31.302_references_DOI_IzUSmKQIUZPY8dV6IvOCdhjrXK4"},{"@type":"CROSSREF","@value":"10.1097/aci.0000000000000444_references_DOI_IzUSmKQIUZPY8dV6IvOCdhjrXK4"}]}