{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994785964672.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1476-5381.1989.tb12667.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1989.tb12667.x"}},{"identifier":{"@type":"URI","@value":"https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1989.tb12667.x"}},{"identifier":{"@type":"PMID","@value":"2692753"}}],"dc:title":[{"@value":"Potent NMDA‐like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord"}],"description":[{"notation":[{"@value":"1. Neuropharmacological actions of all possible-state isomers of alpha-(carboxycyclopropyl)glycine (CCG), conformationally restricted analogues of glutamate, were examined for electrophysiological effects in the isolated spinal cord of the newborn rat. 2. Eight CCG stereoisomers demonstrated a large variety of depolarizing activities. Among them, the (2R, 3S, 4S) isomers of CCG (D-CCG-II) showed the most potent depolarizing activity, followed by the (2S, 3R, 4S) isomer (L-CCG-IV). 3. The depolarization evoked by L-CCG-IV, D-CCG-II and other D-CCG isomers was effectively depressed by N-methyl-D-aspartate (NMDA) antagonists. D-CCG-II was about 5 times more potent than NMDA in causing a depolarization. 4. The (2S, 3S, 4S) isomer of CCG (L-CCG-I) was more potent than L-glutamate in causing a depolarization of spinal motoneurones. The depolarization was slightly depressed by NMDA antagonists, but residual amplitudes of responses to L-CCG-I in the presence of NMDA antagonists We almost insensitive to 6,7-dinitro-quinoxaline-2,3-dione (DNQX) or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), suggesting that L-CCG-I might be a novel potent agonist. 5. After application of the (2S, 3S, 4R) isomer of CCG (L-CCG-III), responses to L-glutamate, D- and L-aspartate were markedly enhanced. The enhancement lasted for a period of several hours without a further application of L-CCG-III. 6. L-CCG-III also caused a depolarization, but it seemed unlikely that the potentiation of the glutamate response was directly related to the depolarization evoked by L-CCG-III. 7. The potentiation might be due to inhibition of uptake processes, but L-CCG-III was superior to L-(-)-threo-3-hydroxyaspartate, a potent uptake inhibitor of L-glutamate and L-aspartate, in enhancing the response to L-glutamate in terms of amplitude and duration of responses. 8. CCG isomers should provide useful pharmacological tools for analysis of glutamate neurotransmitter systems."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994785964673","@type":"Researcher","foaf:name":[{"@value":"H. Shinozaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994785964800","@type":"Researcher","foaf:name":[{"@value":"M. Ishida"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994785964672","@type":"Researcher","foaf:name":[{"@value":"K. Shimamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994785964801","@type":"Researcher","foaf:name":[{"@value":"Y. Ohfune"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00071188"},{"@type":"EISSN","@value":"14765381"}],"prism:publicationName":[{"@value":"British Journal of Pharmacology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"1989-12","prism:volume":"98","prism:number":"4","prism:startingPage":"1213","prism:endingPage":"1224"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1989.tb12667.x"},{"@id":"https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1989.tb12667.x"}],"createdAt":"2012-07-20","modifiedAt":"2023-09-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Motor%20Neurons","dc:title":"Motor Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Aspartic%20Acid","dc:title":"Aspartic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=N-Methylaspartate","dc:title":"N-Methylaspartate"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Conformation","dc:title":"Molecular Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Inbred%20Strains","dc:title":"Rats, Inbred Strains"},{"@id":"https://cir.nii.ac.jp/all?q=Stereoisomerism","dc:title":"Stereoisomerism"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acids,%20Dicarboxylic","dc:title":"Amino Acids, Dicarboxylic"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Electrophysiology","dc:title":"Electrophysiology"},{"@id":"https://cir.nii.ac.jp/all?q=Animals,%20Newborn","dc:title":"Animals, Newborn"},{"@id":"https://cir.nii.ac.jp/all?q=Glutamates","dc:title":"Glutamates"},{"@id":"https://cir.nii.ac.jp/all?q=Spinal%20Cord","dc:title":"Spinal Cord"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1521417754931742592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Award Accounts : The Chemical Society of Japan Award for Creative Work for 2013 : Elucidation of Excitatory Neurotransmission and Membrane Protein Integration Mechanisms"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1476-5381.1989.tb12667.x"},{"@type":"OPENAIRE","@value":"doi_dedup___::9fb92c1af64f221b9e6a19ae66a6e706"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20150336_references_DOI_GHxtXbEIQCqy0c9fRQdMpWgDXu8"}]}