{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994805388288.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1182/blood-2017-01-764274"}},{"identifier":{"@type":"URI","@value":"http://ashpublications.org/blood/article-pdf/130/13/1523/1402683/blood764274.pdf"}}],"dc:title":[{"@value":"Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Key Points</jats:title>\n               <jats:p>Tolerance of oxidative DNA lesions ensures the genomic and functional integrity of hematopoietic stem and precursor cells. Endogenous DNA damage–induced replication stress is associated with mitochondrial dysfunction.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994805388423","@type":"Researcher","foaf:name":[{"@value":"Ana Martín-Pardillos"}],"jpcoar:affiliationName":[{"@value":"Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388418","@type":"Researcher","foaf:name":[{"@value":"Anastasia Tsaalbi-Shtylik"}],"jpcoar:affiliationName":[{"@value":"Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388291","@type":"Researcher","foaf:name":[{"@value":"Si Chen"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388416","@type":"Researcher","foaf:name":[{"@value":"Seka Lazare"}],"jpcoar:affiliationName":[{"@value":"European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388294","@type":"Researcher","foaf:name":[{"@value":"Ronald P. van Os"}],"jpcoar:affiliationName":[{"@value":"European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388419","@type":"Researcher","foaf:name":[{"@value":"Albertina Dethmers-Ausema"}],"jpcoar:affiliationName":[{"@value":"European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388292","@type":"Researcher","foaf:name":[{"@value":"Nima Borhan Fakouri"}],"jpcoar:affiliationName":[{"@value":"Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388296","@type":"Researcher","foaf:name":[{"@value":"Matthias Bosshard"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388295","@type":"Researcher","foaf:name":[{"@value":"Rossana Aprigliano"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland;"},{"@value":"Department of Cancer Research and Molecular Medicine, Norwegian University for Science and Technology, Trondheim, Norway;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388417","@type":"Researcher","foaf:name":[{"@value":"Barbara van Loon"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland;"},{"@value":"Department of Cancer Research and Molecular Medicine, Norwegian University for Science and Technology, Trondheim, Norway;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388288","@type":"Researcher","foaf:name":[{"@value":"Daniela C. F. Salvatori"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388420","@type":"Researcher","foaf:name":[{"@value":"Keiji Hashimoto"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacological Sciences, Stony Brook University Medical School, Stony Brook, NY"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388290","@type":"Researcher","foaf:name":[{"@value":"Celia Dingemanse-van der Spek"}],"jpcoar:affiliationName":[{"@value":"Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388289","@type":"Researcher","foaf:name":[{"@value":"Masaaki Moriya"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacological Sciences, Stony Brook University Medical School, Stony Brook, NY"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388293","@type":"Researcher","foaf:name":[{"@value":"Lene Juel Rasmussen"}],"jpcoar:affiliationName":[{"@value":"Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388421","@type":"Researcher","foaf:name":[{"@value":"Gerald de Haan"}],"jpcoar:affiliationName":[{"@value":"European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388297","@type":"Researcher","foaf:name":[{"@value":"Marc H. G. P. Raaijmakers"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994805388422","@type":"Researcher","foaf:name":[{"@value":"Niels de Wind"}],"jpcoar:affiliationName":[{"@value":"Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00064971"},{"@type":"EISSN","@value":"15280020"}],"prism:publicationName":[{"@value":"Blood"}],"dc:publisher":[{"@value":"American Society of Hematology"}],"prism:publicationDate":"2017-09-28","prism:volume":"130","prism:number":"13","prism:startingPage":"1523","prism:endingPage":"1534"},"reviewed":"false","url":[{"@id":"http://ashpublications.org/blood/article-pdf/130/13/1523/1402683/blood764274.pdf"}],"createdAt":"2017-08-22","modifiedAt":"2019-11-19","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360288691694416768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"REV1-POL ζ Inhibition and Cancer Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317024392832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The in vivo role of Rev1 in mutagenesis and carcinogenesis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1182/blood-2017-01-764274"},{"@type":"CROSSREF","@value":"10.1016/j.molcel.2019.07.012_references_DOI_24JgcsjvrTQX8D5bw3npEWvIlFT"},{"@type":"CROSSREF","@value":"10.1186/s41021-020-0148-1_references_DOI_24JgcsjvrTQX8D5bw3npEWvIlFT"}]}