Bioreductive deprotection of 4-nitrobenzyl group on thymine base in oligonucleotides for the activation of duplex formation
書誌事項
- 公開日
- 2015-12
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
-
- 10.1016/j.bmcl.2015.10.025
- 公開者
- Elsevier BV
この論文をさがす
説明
Oligonucleotides containing 4-O-(4-NO2-benzyl)thymine residues were synthesized to assess potential prodrug-type action against hypoxic cells. These modified oligonucleotides were incapable of stable duplex formation under non-hypoxic conditions. However, following deprotection of the thymine residues under bioreductive conditions, the deprotected oligonucleotides were able to form stable duplexes with target oligonucleotides.
収録刊行物
-
- Bioorganic & Medicinal Chemistry Letters
-
Bioorganic & Medicinal Chemistry Letters 25 (23), 5632-5635, 2015-12
Elsevier BV
