{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994880596992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/s40738-020-00074-3"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1186/s40738-020-00074-3.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1186/s40738-020-00074-3/fulltext.html"}}],"dc:title":[{"@value":"Staging of the estrous cycle and induction of estrus in experimental rodents: an update"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>Determination of the phases of the estrous cycle and induction of estrus (heat) in experimental animals remains useful, especially in reproductive function research.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Main body of the abstract</jats:title>\n                <jats:p>This review provides a detailed description and discusses extensively the variations observed in different phases of the estrous cycle in laboratory animals using rats and mice as examples. It also illustrates how these phases can be determined and how to induce estrus ‘heat’ when required. The phases of the estrous cycle can be determined using various methods such as visual assessment, vaginal smear/cytology, histology of female reproductive organs (vagina, uterus and ovaries), vaginal wall impedance assessment and determination of urine biochemical parameters. Female animals can be artificially brought to estrus phase ‘heat’ to make them receptive to male counterparts.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusion</jats:title>\n                <jats:p>Determination of the length and phases of the estrous cycle and induction of estrus are useful in teaching and research and evaluating the effects of drugs/chemicals on the reproductive functions.</jats:p>\n              </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994880596864","@type":"Researcher","foaf:name":[{"@value":"Ayodeji Folorunsho Ajayi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994880596992","@type":"Researcher","foaf:name":[{"@value":"Roland Eghoghosoa Akhigbe"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20547099"}],"prism:publicationName":[{"@value":"Fertility Research and Practice"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2020-03-14","prism:volume":"6","prism:number":"1","prism:startingPage":"5"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1186/s40738-020-00074-3.pdf"},{"@id":"http://link.springer.com/article/10.1186/s40738-020-00074-3/fulltext.html"}],"createdAt":"2020-03-14","modifiedAt":"2021-03-14","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142731703808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643788723328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Temporal relationship between alterations in the gut microbiome and the development of polycystic ovary syndrome‐like phenotypes in prenatally androgenized female mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757191229440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302866851445120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of the prenatal and postnatal nurturing environment on the phenotype and gut microbiota of mice with polycystic ovary syndrome induced by prenatal androgen exposure: a cross-fostering study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092839228288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Size-dependent biodistribution of thiol-organosilica nanoparticles and F4/80 protein expression in the genital tract of female mice after intravaginal administration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855579467648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SIK2 and SIK3 Differentially Regulate Mouse Granulosa Cell Response to Exogenous Gonadotropins In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1390585636769671296","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"発育期における長期間の自発走運動とカロリー制限が雌ラット骨格筋の細胞内シグナル伝達に及ぼす影響"},{"@language":"en","@value":"Effects of long-term voluntary running exercise and caloric restriction during development on intracellular signaling in female rat skeletal muscles"},{"@language":"ja-Kana","@value":"ハツイクキ ニ オケル チョウキカン ノ ジハツソウ ウンドウ ト カロリー セイゲン ガ メス ラット コッカクキン ノ サイボウ ナイ シグナル デンタツ ニ オヨボス エイキョウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1186/s40738-020-00074-3"},{"@type":"CROSSREF","@value":"10.1093/molehr/gaab003_references_DOI_UJu2RyhzUuhaXTM3Cl0y5lBgAJm"},{"@type":"CROSSREF","@value":"10.1096/fj.202101051r_references_DOI_UJu2RyhzUuhaXTM3Cl0y5lBgAJm"},{"@type":"CROSSREF","@value":"10.3390/biomedicines11030985_references_DOI_UJu2RyhzUuhaXTM3Cl0y5lBgAJm"},{"@type":"CROSSREF","@value":"10.3389/fcell.2024.1365624_references_DOI_UJu2RyhzUuhaXTM3Cl0y5lBgAJm"},{"@type":"CROSSREF","@value":"10.1007/s00418-021-01974-1_references_DOI_UJu2RyhzUuhaXTM3Cl0y5lBgAJm"},{"@type":"CROSSREF","@value":"10.7600/jspfsm.74.155_references_DOI_UJu2RyhzUuhaXTM3Cl0y5lBgAJm"},{"@type":"CROSSREF","@value":"10.1210/endocr/bqae107_references_DOI_UJu2RyhzUuhaXTM3Cl0y5lBgAJm"}]}